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Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments

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Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments

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dc.contributor.author Trujillo Guillen, Macarena es_ES
dc.contributor.author Castellvi, Quim es_ES
dc.contributor.author Burdío, Fernando es_ES
dc.contributor.author Sánchez Velázquez, Patricia es_ES
dc.contributor.author Ivorra, Antoni es_ES
dc.contributor.author Andaluz, Anna es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.date.accessioned 2014-10-13T12:38:45Z
dc.date.available 2014-10-13T12:38:45Z
dc.date.issued 2013-05
dc.identifier.issn 0265-6736
dc.identifier.uri http://hdl.handle.net/10251/43198
dc.description.abstract Purpose: The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to increase the coagulation volume in comparison to that created exclusively by RFA. Materials and methods: A modelling study and in vivo experimental study were used. A Cool-tip RF applicator was used both for EP and RFA. Results: Overall, the results did not show any synergy effect from using the hybrid technique. Applying EP pulses prior to RFA did not increase the coagulation zone obtained and the lesions were almost identical. Additional computer simulations provided an explanation for this; the effect of reducing blood perfusion by thermal damage during RFA completely masks the effect of reducing blood perfusion by EP. This is because both thermal damage and EP affect the same zone, i.e. the tissue around the electrode. Conclusions: Our computer modelling and in vivo experimental findings suggest that the combination of EP and RFA with monopolar applicators does not provide an additional benefit over the use of RFA alone. es_ES
dc.description.sponsorship This work received financial support from the Spanish 'Plan Nacional de I + D + I del Ministerio de Ciencia e Innovacion' Grant nos. TEC2011-27133-C02-01,02 and TEC2010-17285, from the European Commission through the Marie Curie IRG grant TAMIVIVE (256376) and from the Universitat Politecnica de Valencia (INNOVA11-01-5502; and PAID-06-11 Ref. 1988). The linguistic revision of this paper was funded by the Universitat Politecnica de Valencia, Spain. The authors alone are responsible for the content and writing of the paper. en_EN
dc.language Inglés es_ES
dc.publisher Informa Healthcare es_ES
dc.relation.ispartof International Journal of Hyperthermia es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Tumour ablation es_ES
dc.subject Radiofrequency ablation es_ES
dc.subject In vivo model es_ES
dc.subject Electroporation es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3109/02656736.2013.777854
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//TEC2010-17285/ES/METODOS Y HERRAMIENTAS PARA LA ELECTROPORACION IN VIVO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/256376/EU/Tools and methods for in vivo electroporation/ en_EN
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-06-11-1988/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//INNOVA11-01- 5502/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2011-27133-C02-01/ES/MODELADO TEORICO Y EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2011-27133-C02-02/ES/EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Matemática Pura y Aplicada - Institut Universitari de Matemàtica Pura i Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Trujillo Guillen, M.; Castellvi, Q.; Burdío, F.; Sánchez Velázquez, P.; Ivorra, A.; Andaluz, A.; Berjano, E. (2013). Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments. International Journal of Hyperthermia. 29(3):211-218. https://doi.org/10.3109/02656736.2013.777854 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.3109/02656736.2013.777854 es_ES
dc.description.upvformatpinicio 211 es_ES
dc.description.upvformatpfin 218 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 29 es_ES
dc.description.issue 3 es_ES
dc.relation.senia 255193
dc.contributor.funder Universitat Politècnica de València es_ES
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