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Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture

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Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture

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dc.contributor.author Ayala, Guillermo es_ES
dc.contributor.author Diez, Fernando es_ES
dc.contributor.author Gasso Matoses, María Teresa es_ES
dc.contributor.author Jones, Brian E. es_ES
dc.contributor.author Martin-Portugues, Rafae es_ES
dc.contributor.author Ramiro-Aparicio, Juan es_ES
dc.date.accessioned 2017-05-23T08:13:53Z
dc.date.available 2017-05-23T08:13:53Z
dc.date.issued 2016-04
dc.identifier.issn 0378-5173
dc.identifier.uri http://hdl.handle.net/10251/81638
dc.description This is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics 503 (2016) 36–40. DOI 10.1016/j.ijpharm.2016.02.017. es_ES
dc.description.abstract The internal lubricant content (ILC) of inhalation grade HPMC capsules is a key factor to ensure good powder release when the patient inhales a medicine from a dry powder inhaler (DPI). Powder release from capsules has been shown to be influenced by the ILC. The characteristics used to measure this are the emitted dose, fine particle fraction and mass median aerodynamic diameter. In addition the ILC level is critical for capsule shell manufacture because it is an essential part of the process that cannot work without it. An experiment has been applied to the manufacture of inhalation capsules with the required ILC. A full factorial model was used to identify the controlling factors and from this a linear model has been proposed to improve control of the process. (C) 2016 Elsevier B.V. All rights reserved. es_ES
dc.description.sponsorship This research was supported by Qualicaps Europe, S.A.U.; Spanish DGI Grant no. MTM2014-58159-P (M.T. Gasso) and G. Ayala (DPI2013-47279-C2-1-R), en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof International Journal of Pharmaceutics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject HPMC capsules es_ES
dc.subject Internal lubricant es_ES
dc.subject Aerosolization es_ES
dc.subject Dry powder inhaler (DPI) es_ES
dc.subject Linear models es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ijpharm.2016.02.017
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//DPI2013-47279-C2-1-R/ES/HERRAMIENTAS PARA LA PREDICCION DE LA TALLA Y EL AJUSTE DE ROPA INFANTIL A PARTIR DE LA RECONSTRUCCION 3D DEL CUERPO Y DE TECNICAS BIG DATA/ / es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MTM2014-58159-P/ES/PRECONDICIONADORES PARA SISTEMAS DE ECUACIONES LINEALES, PROBLEMAS DE MINIMOS CUADRADOS, CALCULO DE VALORES PROPIOS Y APLICACIONES TECNOLOGICAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escola Tècnica Superior d'Enginyeria Informàtica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Matemática Multidisciplinar - Institut Universitari de Matemàtica Multidisciplinària es_ES
dc.description.bibliographicCitation Ayala, G.; Diez, F.; Gasso Matoses, MT.; Jones, BE.; Martin-Portugues, R.; Ramiro-Aparicio, J. (2016). Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture. International Journal of Pharmaceutics. 503(1-2):36-40. doi:10.1016/j.ijpharm.2016.02.017 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.ijpharm.2016.02.017 es_ES
dc.description.upvformatpinicio 36 es_ES
dc.description.upvformatpfin 40 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 503 es_ES
dc.description.issue 1-2 es_ES
dc.relation.senia 316766 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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