The presented work shows the incorporation of pharmacoeconomic studies in the hospital, implementing pharmacoeconomic studies in current clinical situations adapted to our environment, using analysis of uncertainties, like analysis of structural sensitivity, shows to ensure the robustness of the final results. It Shows too the usefulness of measuring the quality of life related to the health care of patients. The information provided by health studies influences on the pharmacotherapeutic decision-making and in justifying clinical services. It is presented in nine chapters which include published studies with general discussions on the main strategies for the incorporation of pharmacoeconomics into the hospital, such as: a) use the published literature, b) by construction of models, c) performing a clinical trial or pragmatic or observational study. It concludes that it is feasible to apply the outcomes of health studies in the everyday hospital practice in order to make better clinical decisions. All the options offered by pharmacoeconomic models and sensitivity analysis must be used, either deterministic or stochastic, since they are considered as a necessary tool to verify the robustness of their results. Structural sensitivity analysis provides valuable information about the problem being represented, and increase the validity and reliability of the model. The quality of life related to health is a result in itself and we must incorporate it as a variable in our studies. Assistance programs of pharmaceutical care and new clinical services will be enhanced by applying the implementation of this technology to demonstrate its value.