The importance of Competence-based Higher Education has increased in recent years as a result of the process of adaptation of universities to the European Higher Education Area. The new study programmes of Grado and Master emphasize on learning outcomes that students obtain after their studies, as opposed to the previous degrees, mainly focused on the acquisition of knowledge. This change of approach implies a need for a methodological change, not only regarding the definition and planning of the academic resources but also related to the selection of new teaching methods. In this context, some university professors are already wondering whether the traditional modes of teaching and learning are appropriate to meet these new circumstances and consequently they are gradually introducing methodological innovations, based on the so-called active learning contexts. In the next years universities are expected to plan and manage this change towards this new methodological approach from the institutional level. However, the responsibility for implementation in practice of such plans eventually rests on professors. Sometimes this situation involves an additional difficulty to their work, as they feel some lack of training to develope their daily tasks with this new approach. Therefore, research about teaching - learning skills in university seems to be absolutely necessary in order to facilitate the assimilation of the methodological innovations and prevent the adaptation of old study programmes becomes a mere aesthetic and formal adjustment of the traditional modes of teaching and learning. The aim of this work is to model these processes of teaching and learning for the acquisition of competencies in Higher Education, taking into consideration how different factors related to the academic and personal environment of students could influence the final achievement of learning outcomes. With this aim, it is exposed an extensive review of the concepts of competence and learning approach, and a description of the university academic contexts and models of teaching and learning in Higher Education. Secondly, each of the relationships between competencies acquired during Higher Education and the different factors belonging to the academic and personal environment of student is analyzed. Additionally the effect of effect modifiers, such as the field of study, is studied. This effect is mainly focused on the introduction of relations of interaction and confusion between variables. Finally, after examining the relationships between contextual factors of students, the measuring instruments used in the REFLEX Project have been validated. This instruments are based on different modes of teaching and learning used by professors and competencies acquired at University. In this stage Confirmatory Factor Analysis and Measurement Invariance techniques have been applied. In both cases the fit of these measurement models has been considered excellent or very high. From here on, a structural model has been proposed, based on previous researches and exploratory analysis. This model has been successfully applied to different fields of study and the differences between universities have been valued as no significant. The fit of this model has been considered good, considering the increase of complexity regarding to the previous models. Specifically for the Science field some changes to the basic model have been suggested from an exploratory point of view. These modifications is consistent with the learning environment in this field of study.