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Browsing by Author "Gisbert Roca, Fernando"

Now showing items 1-17 of 17

A Hyaluronic Acid Demilune Scaffold and Polypyrrole-Coated Fibers Carrying Embedded Human Neural Precursor Cells and Curcumin for Surface Capping of Spinal Cord Injuries

Elkhenany, Hoda; Bonilla, Pablo; Giraldo-Reboloso, Esther; Alastrue Agudo, Ana; Edel, Michael J.; Vicent, María Jesus; Gisbert-Roca, Fernando; Martínez-Ramos, Cristina; Rodriguez Doblado, Laura; Monleón Pradas, Manuel; Moreno Manzano, Victoria (MDPI AG, 2021-12)

[EN] Tissue engineering, including cell transplantation and the application of biomaterials and bioactive molecules, represents a promising approach for regeneration following spinal cord injury (SCI). We designed a ...
Acute transplantation of NPC on electrospun poly-lactic acid membranes containing curcumin into the injured spinal cord reduces neuronal degeneration

Sánchez-Martín, María del Mar; Giraldo-Reboloso, Esther; Gisbert-Roca, Fernando; Alastrue-Agudo, Ana; Martínez-Ramos, Cristina; Monleón Pradas, Manuel; Moreno-Manzano, Victoria (Frontiers Media SA, 2023-11-13)

[EN] Effective spinal cord injury (SCI) treatment remains a significant challenge, given the complex nature of the primary injury and associated devastating loss of neural activity. Neural progenitor cell (NPC)-based therapy ...
Alginate-Agarose Hydrogels Improve the In Vitro Differentiation of Human Dental Pulp Stem Cells in Chondrocytes. A Histological Study

Oliver-Ferrándiz, María; Milián, Lara; Sancho-Tello, María; Martín de Llano, José Javier; Gisbert-Roca, Fernando; Martínez-Ramos, Cristina; Carda, Carmen; Mata, Manuel (MDPI AG, 2021-07)

[EN] Matrix-assisted autologous chondrocyte implantation (MACI) has shown promising results for cartilage repair, combining cultured chondrocytes and hydrogels, including alginate. The ability of chondrocytes for MACI is ...
Axonal extension from dorsal root ganglia on fibrillar and highly aligned poly(lactic acid)-polypyrrole substrates obtained by two different techniques: Electrospun nanofibres and extruded microfibres

Gisbert-Roca, Fernando; Más Estellés, Jorge; Monleón Pradas, Manuel; Martínez-Ramos, Cristina (Elsevier, 2020-11-15)

[EN] The biological behaviour of Schwann cells (SCs) and dorsal root ganglia (DRG) on fibrillar, highly aligned and electroconductive substrates obtained by two different techniques is studied. Mats formed by nanometer-sized ...
BDNF-Gene Transfected Schwann Cell-Assisted Axonal Extension and Sprouting on New PLA-PPy Microfiber Substrates

Gisbert-Roca, Fernando; André, Franck M.; Más Estellés, Jorge; Monleón Pradas, Manuel; Mir, Lluis M.; Martínez-Ramos, Cristina (John Wiley & Sons, 2021-05)

[EN] The work here reported analyzes the effect of increased efficiency of brainderived neurotrophic factor (BDNF) production by electroporated Schwann cells (SCs) on the axonal extension in a coculture system on a biomaterial ...
Conduits based on the combination of hyaluronic acid and silk fibroin: Characterization, in vitro studies and in vivo biocompatibility

Gisbert-Roca, Fernando; Lozano Picazo, Paloma; Pérez-Rigueiro, José; Guinea Tortuero, Gustavo Victor; Monleón Pradas, Manuel; Martínez-Ramos, Cristina (Elsevier, 2020-04-01)

[EN] We address the production of structures intended as conduits made from natural biopolymers, capable of promoting the regeneration of axonal tracts. We combine hyaluronic acid (HA) and silk fibroin (SF) with the aim ...
Desarrollo de un dispositivo in vitro para guiar el crecimiento axonal aplicando estimulación eléctrica externa

Serrano Requena, Sara (Universitat Politècnica de València, 2021-10-08)

[ES] Las patologías que se derivan en el sistema nervioso llevan asociadas la dificultad de regeneración del propio tejido, especialmente cuando se habla del Sistema Nervioso Central (SNC). Es debido a esta problemática ...
Diseño de nuevos biomateriales por combinación de fibroina y ácido hialurónico

Gisbert Roca, Fernando (Universitat Politècnica de València, 2018-01-09)

[ES] Las lesiones y enfermedades que afectan al sistema nervioso, tanto central (SNC) como periférico (SNP), poseen incidencias y prevalencias muy elevadas, afectando a millones de personas en todo el mundo. Además, el ...
Diseño, mecanizado y construcción de un bioreactor para estimulación eléctrica y magnética in vitro de cultivos neurales

Ferrando Huertas, Paula (Universitat Politècnica de València, 2022-09-07)

[ES] Los trastornos y las lesiones del sistema nervioso son un problema que la medicina aún no puede resolver. No obstante, nuevos métodos y técnicas de regeneración neural están en constante desarrollo. Uno de ellos es ...
Electric field bridging-effect in electrified microfibrils' scaffolds

Fontana, Sara; Caramazza, Laura; Marracino, Paolo; Cuenca-Ortolá, Irene; Colella, Micol; Dolciotti, Noemi; Paffi, Alessandra; Gisbert-Roca, Fernando; Ivashchenko, Sergiy; Más Estellés, Jorge; Consales, Claudia; Balucani, Marco; Apollonio, Francesca; Liberti, Micaela (Frontiers Media S.A., 2023-10-25)

[EN] Introduction: The use of biocompatible scaffolds combined with the implantation of neural stem cells, is increasingly being investigated to promote the regeneration of damaged neural tissue, for instance, after a ...
Electrical Stimulation Increases Axonal Growth from Dorsal Root Ganglia Co-Cultured with Schwann Cells in Highly Aligned PLA-PPy-Au Microfiber Substrates

Gisbert Roca, Fernando; Serrano Requena, Sara; Monleón Pradas, Manuel; Martínez-Ramos, Cristina (MDPI AG, 2022-06)

[EN] Nerve regeneration is a slow process that needs to be guided for distances greater than 5 mm. For this reason, different strategies are being studied to guide axonal growth and accelerate the axonal growth rate. In ...
Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives

Gómez-Álvarez, María; Bueno-Fernandez, Clara; Rodríguez-Eguren, Adolfo; Francés-Herrero, Emilio; Agustina-Hernández, Marcos; Faus, Amparo; Gisbert-Roca, Fernando; Martínez-Ramos, Cristina; Galán, Amparo; Pellicer, Antonio; Ferrero, Hortensia; Cervelló, Irene (Wiley-VCH, 2024-04)

[EN] The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential for developing new strategies to improve ...
Modelado del efecto eléctrico de los fármacos voltaje-dependientes en las células ventriculares de corazón: nuevo marco teórico

Gisbert Roca, Fernando (Universitat Politècnica de València, 2016-07-12)

[ES] El primer objetivo del programa es aplicar un nuevo modelo de estimación del factor de bloqueo de una corriente iónica que se ha desarrollado para tener en cuenta su dependencia con el voltaje en el caso del uso de ...
Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect

Gisbert Roca, Fernando; Gil Santos, Luis; Mata Roig, Manuel; Milian Medina, Lara; Martínez-Ramos, Cristina; Monleón Pradas, Manuel (MDPI AG, 2022-05)

[EN] The gold standard for the treatment of peripheral nerve injuries, the autograft, presents several drawbacks, and engineered constructs are currently suitable only for short gaps or small diameter nerves. Here, we study ...
Polylactic Acid Nanofiber Membranes Grafted with Carbon Nanotubes with Enhanced Mechanical and Electrical Properties

Gisbert-Roca, Fernando; Martínez-Ramos, Cristina; Ivashchenko, Sergiy; Garcia-Bernabe, Abel; Compañ Moreno, Vicente; Monleón Pradas, Manuel (American Chemical Society, 2023-07-12)

[EN] Electroconductive materials based on poly(lactic acid) (PLA) electrospinning membranes grafted with carbon nanotubes (CNTs) functionalized with the carboxylic group R-COOH have been obtained. PLA electrospun membranes ...
Solid Polymer Electrolytes Based on Polylactic Acid Nanofiber Mats Coated with Polypyrrole

Gisbert-Roca, Fernando; Garcia-Bernabe, Abel; Compañ Moreno, Vicente; Martínez-Ramos, Cristina; Monleón Pradas, Manuel (John Wiley & Sons, 2021-02)

[EN] The production of electroconductive nanofiber membranes made from polylactic acid (PLA) coated with polypyrrole (PPy) is investigated, performing a scanning of different reaction parameters and studying their ...
Strategies for Guidance and Electrical and Biological Stimulation in a Neural Regeneration Device

Gisbert Roca, Fernando (Universitat Politècnica de València, 2022-11-18)

[ES] Actualmente las lesiones del sistema nervioso periférico que conllevan una pérdida de continuidad de los haces axonales suelen implicar secuelas de tipo permanente. Es cierto que en el sistema nervioso periférico ...