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Browsing by Author "Rodrigo Navarro, Aleixandre"

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Browsing by Author "Rodrigo Navarro, Aleixandre"

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    A Hydrogel Platform that Incorporates Laminin Isoforms for Efficient Presentation of Growth Factors - Neural Growth and Osteogenesis 
    Dobre, Oana; Oliva, Mariana A. G.; Ciccone, Giuseppe; Trujillo-Muñoz, Sara; Rodrigo Navarro, Aleixandre; Venters, Douglas Cormac; Llopis Hernández, Virginia; Vassalli, Massimo; González García, Cristina; Dalby, Matthew J.; Salmerón Sánchez, Manuel (John Wiley & Sons, 2021-05)
    [EN] Laminins (LMs) are important structural proteins of the extracellular matrix (ECM). The abundance of every LM isoform is tissue-dependent, suggesting that LM has tissue-specific roles. LM binds growth factors (GFs), ...
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    Biochemical- and Biophysical-Induced Barriergenesis in the Blood¿Brain Barrier: A Review of Barriergenic Factors for Use in In Vitro Models 
    Schofield, Christina L.; Rodrigo-Navarro, Aleixandre; Dalby, Matthew J.; Van Agtmael, Tom; Salmerón Sánchez, Manuel (Wiley-VCH Verlag GmbH & Co. KGaA, 2021-05)
    [EN] Central nervous system (CNS) pathologies are a prevalent problem in aging populations, creating a need to understand the underlying events in these diseases and develop efficient CNS-targeting drugs. The importance ...
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    Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway 
    Rico Tortosa, Patricia María; Rodrigo Navarro, Aleixandre; Sánchez-Pérez, Laura; Salmerón Sánchez, Manuel (Springer Nature, 2020-11-27)
    [EN] The intrinsic properties of mesenchymal stem cells (MSCs) make them ideal candidates for tissue engineering applications. Efforts have been made to control MSC behavior by using material systems to engineer synthetic ...
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    Controlled Assembly of Fibronectin Nanofibrils Triggered by Random Copolymer Chemistry 
    MNATSAKANYAN, HAYK; Rico Tortosa, Patricia María; Grigoriou, Eleni; Maturana Candelas, Aarón; Rodrigo Navarro, Aleixandre; Salmerón Sánchez, Manuel; Sabater i Serra, Roser (American Chemical Society, 2015-08-19)
    Fibronectin fibrillogenesis is the physiological process by which cells elaborate a fibrous FN matrix. Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) ...
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    Engineered living biomaterials 
    Rodrigo-Navarro, Aleixandre; Sankaran, Shrikrishnan; Dalby, Matthew J.; del Campo, Aránzazu; Salmerón Sánchez, Manuel (Nature Publishing Group, 2021-12)
    [EN] Biomaterials have evolved from inert materials that lack interaction with the body to biologically active, instructive materials that host and provide signals to surrounding cells and tissues. Engineered living materials ...
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    Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization 
    Moulisova, Vladimira; González García, Cristina; Cantini, Marco; Rodrigo Navarro, Aleixandre; Weaver, Jessica; Costell, Mercedes; Sabater i Serra, Roser; Dalby, Matthew J.; García, Andrés J.; Salmerón Sánchez, Manuel (Elsevier, 2017)
    [EN] We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous ...
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    Functional living biointerfaces to direct cell-material interaction 
    Rodrigo Navarro, Aleixandre (Universitat Politècnica de València, 2015-06-10)
    [EN] This thesis deals with the development of a living biointerface between synthetic substrates and living cells to engineer cell-material interactions for tissue engineering purposes. This living biointerface is made ...
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    Functional Living Biointerphases 
    Saadeddin Saadeddin, Anas; Rodrigo Navarro, Aleixandre; Monedero, Vicente; Rico Tortosa, Patricia María; Moratal Pérez, David; González-Martín, María Luisa; Navarro, David; García, Andrés J.; Salmerón Sánchez, Manuel (Wiley, 2013-09)
    Lactococcus lactis is modified to express a fibronectin fragment (FNIII₇₋₁₀) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal ...
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    Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering 
    POVEDA-REYES, SARA; Rodrigo Navarro, Aleixandre; Gamboa Martínez, Tatiana Carolina; Rodríguez-Cabello, José Carlos; Quintanilla-Sierra, Luis; Edlund, Ulrica; Gallego Ferrer, Gloria (Elsevier, 2015-09-15)
    [EN] Poly(L-lactic acid) (PLLA) microfibers were surface functionalized by graft photopolymerization of 2-hydroxyethyl methacrylate (HEMA) onto the fiber surface. Grafted fibers were easily dispersed in enzymatically gelling ...
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    Living biointerfaces based on non-pathogenic bacteria to direct cell differentiation 
    Rodrigo Navarro, Aleixandre; Rico Tortosa, Patricia María; Saadeddin Saadeddin, Anas; Garcia, Andres J.; Salmerón Sánchez, Manuel (Nature Publishing Group, 2014-07-28)
    Genetically modified Lactococcus lactis, non-pathogenic bacteria expressing the FNIII7-10 fibronectin fragment as a protein membrane have been used to create a living biointerface between synthetic materials and mammalian ...
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    Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization 
    Rico Tortosa, Patricia María; Rodrigo Navarro, Aleixandre; La Peña Del Rivero, Marcos De; Moulisova, Vladimira; Costell, Mercedes; Salmerón Sánchez, Manuel (John Wiley & Sons, 2018-10-30)
    [EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and ...