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Browsing by Author "Vila, Carlos"

Now showing items 1-15 of 15

Catalytic Diastereo- and Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols through a Vinylogous Aldol Reaction of Alkylidenepyrazolones with Trifluoromethyl Ketones

Carceller-Ferrer, Laura; González del Campo, Aleix; Vila, Carlos; Blay, Gonzalo; Muñoz Roca, María Del Carmen; Pedro, José R. (American Chemical Society, 2022-04-01)

[EN] A diastereo- and enantioselective organocatalyticaldol reaction between alkylidenepyrazolones and trifluoromethylketones leading to chiral tertiary alcohols bearing a trifluoromethylgroup is presented. The methodology ...
Catalytic Diastereo- and Enantioselective Vinylogous Mannich Reaction of Alkylidenepyrazolones to Isatin-Derived Ketimines

Carceller-Ferrer, Laura; Vila, Carlos; Blay, Gonzalo; Muñoz Roca, María Del Carmen; Pedro, José R. (American Chemical Society, 2021-10-01)

[EN] A valuable organocatalytic vinylogous Mannich reaction between alkylidenepyrazolones and isatin-derived ketimines has been successfully established. Squaramide organocatalyst, prepared from quinine, catalyzed the ...
Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines

De Munck, Lode; Vila, Carlos; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2016-12-05)

A catalytic highly enantioselective aza-Reformatsky reaction with cyclic aldimines and ketimines for the synthesis of chiral b-amino esters with good yields and excellent enantioselectivities is reported.Areadily ...
Catalytic enantioselective aza-Reformatsky reaction with seven-membered cyclic imines dibenzo[b,f][1,4]oxazepines

De Munck, Lode; Sukowski, Verena; Vila, Carlos; Muñoz Roca, María Del Carmen; Pedro, José R. (Royal Society of Chemistry, 2017-08-01)

[EN] A catalytic enantioselective aza-Reformatsky reaction is reported with cyclic dibenzo[b,f][1,4]oxazepines and ethyl iodoacetate leading to the synthesis of chiral ethyl 2-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11- ...
Diastereoselective Michael addition of (S)-mandelic acid enolate to 2-arylidene-1,3-diketones: enantioselective diversity-oriented synthesis of densely substituted pyrazoles

Blay, Gonzalo; Fernández, Isabel; Molina, Eva; Muñoz Roca, María Del Carmen; Pedro, Jose R.; Vila, Carlos (Elsevier, 2006-08-21)

[EN] A diversity-oriented approach to enantiomerically pure densely substituted pyrazoles, ¿-aryl-¿-pyrazolylatrolactic acid and ¿-aryl-¿-pyrazolylacetophenones has been developed. The approach utilises the conjugated ...
Enantioselective Addition of Sodium Bisulfite to Nitroalkenes. A Convenient Approach to Chiral Sulfonic Acids

Sheikhi, Ehsan; Rezaei, Narjes; Castilla, Alvaro; Sanz-Marco, Amparo; Vila, Carlos; Muñoz Roca, María Del Carmen; Pedro, Jose R.; Blay, Gonzalo (John Wiley & Sons, 2021-10-07)

[EN] An enantioselective organocatalytic addition of sodium bisulfite to (E)-nitroalkenes has been developed by using a chiral bifunctional organocatalyst. The present methodology provides a variety of chiral beta-nitroe ...
Enantioselective Synthesis of 2-Amino-1,1-diarylalkanes Bearing a Carbocyclic Ring Substituted Indole through Asymmetric Catalytic Reaction of Hydroxyindoles with Nitroalkenes

Vila, Carlos; Rostoll-Berenguer, Jaume; Sánchez-García, Rubén; Blay, Gonzalo; Fernandez, Isabel; Muñoz Roca, María Del Carmen; Pedro, Jose R. (American Chemical Society, 2018-06-15)

[EN] An asymmetric catalytic reaction of hydroxyindoles with nitroalkenes leading to the Friedel-Crafts alkylation in the carbocyclic ring of indole is presented. The method is based on the activating/directing effects of ...
Enantioselective synthesis of 2-substituted-1,4-diketones from (S)-mandelic acid enolate and alpha, beta-enones

Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Muñoz Roca, María Del Carmen; Pedro, Jose R.; Vila, Carlos (Elsevier, 2006-09-22)

[EN] An approach for the synthesis of chiral non-racemic 2-substituted-1,4-diketones from (S)-mandelic acid and ¿,ß-enones has been developed. The reaction of lithium enolate of the 1,3-dioxolan-4-one derived from optically ...
Enantioselective Synthesis of 5-Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis

Martinez-Pardo, Pablo; Blay, Gonzalo; Vila, Carlos; Sanz-Marco, Amparo; Muñoz Roca, María Del Carmen; Pedro, Jose R. (American Chemical Society, 2019)

[EN] The first enantioselective formal [3 + 2] cycloaddition between ¿-isocyanoesters and trifluoromethylketones to give 5-trifluoromethyl-2-oxazolines bearing two contiguous stereogenic centers, one of them being a ...
Metal-Free Diastereo- and Enantioselective Dearomative Formal [3+2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters

Laviós, Adrian; Sanz-Marco, Amparo; Vila, Carlos; Muñoz Roca, María Del Carmen; Pedro, José R.; Blay, Gonzalo (American Chemical Society, 2022-03-25)

[EN] The diastereo- and enantioselective dearomative formal [3 + 2] cycloaddition of 2-nitrobenzofurans and alpha-aryl-alpha isocyanoacetate esters provides tricyclic compounds bearing the 3a,8b-dihydro-1H-benzofuro[2,3-c]pyrrole ...
Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

Montesinos Magraner, Marc; Vila, Carlos; Cantón, Rubén; Blay, Gonzalo; Fernández, Isabel; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2015)

A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a ...
Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

Amr, Fares Ibrahim; Vila, Carlos; Blay, Gonzalo; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2016-05-19)

A quinine-derived thiourea catalysed the enantioselective addition of 4-substituted pyrazolones to isatin-derived ketimines, providing a variety of aminooxindole-pyrazolone adducts containing congested vicinal ...
Organocatalytic Enantioselective Friedel-Crafts Alkylation of 1-Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate

Montesinos Magraner, Marc; Vila, Carlos; Blay, Gonzalo; Fernández, Isabel; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2015-10-12)

An organocatalytic enantioselective Friedel–Crafts alkylation of a series of substituted 1- naphthol derivatives and activated phenols with ethyl trifluoropyruvate, catalyzed by a quinine-derived squaramide, is presented. ...
Organocatalytic Enantioselective Friedel-Crafts Aminoalkylation of Indoles in the Carbocyclic Ring

Montesinos Magraner, Marc; Vila, Carlos; Rendón Patiño, Alejandra; Blay, Gonzalo; Fernández, Isabel; Muñoz Roca, María del Carmen; Pedro, José R. (American Chemical Society, 2016)

The first general catalytic method for the, so far elusive, enantioselective Friedel−Crafts functionalization of indoles in the carbocyclic ring is presented. This transformation contrasts with the usual tendency of these ...
Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

Vila, Carlos; Amr, Fares Ibrahim; Blay, Gonzalo; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2016-05-20)

An efficient one-pot asymmetric synthesis of pyrazoles bearing a chiral quaternary stereocenter has been developed. Quinine-derived thiourea catalyzed the enantioselective addition of pyrazolones to isatin-derived ketimines, ...