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Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells

De La Torre, Cristina; Casanova, Isolda; Acosta, Gerardo; Coll Merino, Mª Carmen; Moreno, María José; Albericio, Fernando; Aznar, Elena; Mangues, Ramón; Royo, Miriam; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Wiley, 2015-02-04)

[EN] B-cell non-Hodgkin s lymphoma (B-NHL) is the most frequent malignant lymphoid neoplasm, which has a high degree of relapse and chemoresist-ance. Thus, strategies to improve currently used therapies are needed. In this ...
Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles

Díez, Paula; Sanchez, Alfredo; Gamella, María; Paloma Martinez-Ruiz; Aznar, Elena; De La Torre, Cristina; Murguía, Jose R.; Martínez-Máñez, Ramón; Villalonga, Reynaldo; Pingarrón, J.M. (American Chemical Society, 2014)

We report herein the design of a smart delivery system in which cargo delivery from capped mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based control unit . The system consists of Janus-type ...

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