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Browsing by Author "Sánchez, Jorge"

Now showing items 1-7 of 7

A Multiscale in Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation. A Translational Study to Guide Ablation Therapy

Sánchez Arciniegas, Jorge Patricio (Universitat Politècnica de València, 2021-07-26)

[ES] La fibrilación auricular es la arritmia cardíaca más común. Durante la fibrilación auricular, el sustrato auricular sufre una serie de cambios o remodelados a nivel eléctrico y estructural. La remodelación eléctrica ...
Estudio mediante simulación computacional de las causas de la acumulación extracelular de potasio en isquemia miocárdica aguda en modelo de conejo

Sánchez Arciniegas, Jorge Patricio (Universitat Politècnica de València, 2017-01-13)

[EN] Acute myocardial ischemia is one of the most common heart diseases. It is produced by metabolic and electrophysiological changes in cells that form the heart muscle. It presents the well-known phenomenon of extracellular ...
Fibrotic Remodeling during Persistent Atrial Fibrillation: In Silico Investigation of the Role of Calcium for Human Atrial Myofibroblast Electrophysiology

Sánchez, Jorge; Trenor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier; Dossel, Olaf; Loewe, Axel (MDPI, 2021-11)

[EN] During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different scales from the molecular level to the tissue level. One central player that contributes to both electrical and structural ...
Heterogeneous Effects of Fibroblast-Myocyte Coupling in Different Regions of the Human Atria Under Conditions of Atrial Fibrillation

Sánchez-Arciniegas, Jorge Patricio; Gomez, Juan F; Martínez-Mateu, Laura; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Trenor Gomis, Beatriz Ana (Frontiers Media SA, 2019-07-04)

[EN] Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by alteration of the action potential (AP) propagation. Under persistent AF, myocytes undergo electrophysiological and structural ...
Heterogeneous effects of fibroblast-myocyte coupling in different regions of the human atria under conditions of atrial fibrillation

Sánchez Arciniegas, Jorge Patricio; Martínez Mateu, Laura; Gómez García, Juan Francisco; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2019-05-13)

[EN] Myofibroblasts differ from fibroblasts in that they develop contractile proteins and exhibit a more depolarized resting membrane potential (Salvarani et al., 2017) and greater membrane capacitance (Sridhar et al., ...
Influence of Fibrotic Tissue Arrangement on Intracardiac Electrograms During Persistent Atrial Fibrillation

Sánchez, Jorge; Nothstein Mark; Unger, Laura; Saiz Rodríguez, Francisco Javier; Trenor Gomis, Beatriz Ana; Dossel, Olaf; Loewe, Axel (IEEE, 2019-09-11)

[EN] Under persistent atrial fibrillation (peAF), cardiac tissue experiences electrophysiological and structural remodeling. Fibrosis in the atrial tissue has an important impact on the myocyte action potential and ...
Using Machine Learning to Characterize Atrial Fibrotic Substrate from Intracardiac Signals with a Hybrid in silico and in vivo Dataset

Sánchez Arciniegas, Jorge Patricio; Luongo, Giorgio; Nothstein, Mark; Unger, Laura A.; Saiz Rodríguez, Francisco Javier; Trenor Gomis, Beatriz Ana; Luik, Armin; Doessel, Olaf; Loewe, Axel (Frontiers Media SA, 2021-07-05)

[EN] In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to the isolation of the pulmonary ...