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Browsing by Author "Sommer, Wolfgang H."

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Browsing by Author "Sommer, Wolfgang H."

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    Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain 
    De Santis, Silvia; Cosa-Liñán, Alejandro; Garcia-Hernandez, Raquel; Dmytrenko, Lesia; Vargova, Lydia; Vorisek, Ivan; Stopponi, Serena; Bach, Patrick; Kirsch, Peter; Kiefer, Falk; Ciccocioppo, Roberto; Sykova, Eva; Moratal, David; Sommer, Wolfgang H.; Canals, Santiago (American Association for the Advancement of Science, 2020-06)
    [EN] Already moderate alcohol consumption has detrimental long-term effects on brain function. However, how alcohol produces its potent addictive effects despite being a weak reinforcer is a poorly understood conundrum ...
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    Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone 
    Bach, Patrick; Weil, Georg; Pompili, Enrico; Hoffmann, Sabine; Hermann, Derik; Vollstädt-Klein, Sabine; Mann, Karl; Pérez-Ramírez, Úrsula; Moratal, David; Canals, Santiago; Dursun, Serdar M.; Greenshaw, Andrew J.; Kirsch, Peter; Kiefer, Falk; Sommer, Wolfgang H. (Blackwell Publishing, 2020-01)
    [EN] During the first weeks of abstinence, alcohol craving in patients may increase or "incubate." We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue ...
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    Multi-modal MRI classifiers identify excessive alcohol consumption and treatment effects in the brain 
    Cosa, Alejandro; Moreno, Andrea; Pacheco-Torres, Jesús; Ciccocioppo, Roberto; Hyytiä, Petri; Sommer, Wolfgang H.; Moratal, David; Canals, Santiago (Blackwell Publishing, 2017)
    [EN] Robust neuroimaging markers of neuropsychiatric disorders have proven difficult to obtain. In alcohol use disorders, profound brain structural deficits can be found in severe alcoholic patients, but the heterogeneity ...
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    Neuroimaging reveals functionally distinct neuronal networks associated with high-level alcohol consumption in two genetic rat models 
    Pallarés, Vicente; Dudek, Mateusz; Moreno, Andrea; Pérez-Ramírez, Úrsula; Moratal, David; Haaranen, Mia; Ciccocioppo, Roberto; Sommer, Wolfgang H.; Canals, Santiago; Hyytiä, Petri (Lippincott Williams & Wilkins, 2021-04)
    [EN] Human imaging data suggest that the motivational processes associated with alcohol reward are reflected in the patterns of neural activation after alcohol or alcohol-related cues. In animal models of alcohol drinking, ...