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Browsing by Author "Merino Sanjuán, Virginia María"

Now showing items 1-15 of 15

Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence

Mangas-Sanjuan, Victor; Pleguezuelos-Villa, María; Merino-Sanjuán, Matilde; Hernández, Mª Jesús; Nácher, Amparo; García-Arieta, Alfredo; Peris, Daniel; Hidalgo, Irene; Soler, Lluís; Sallan, Marta; Merino, Virginia (MDPI AG, 2019-10)

[EN] Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was ...
Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool

Figueroa-Campos, Andrés; Sánchez-Dengra, Bárbara; Merino, Virginia; Dahan, Arik; Gonzalez-Alvarez, Isabel; García-Arieta, Alfredo; Gonzalez-Alvarez, Marta; Bermejo, Marival (MDPI AG, 2020-07)

[EN] The main objective of this investigation was to develop an in vitro-in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development ...
Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

Martínez-Martínez, M.; Rodríguez Berna, Guillermo; Bermejo, Marival; Gonzalez-Alvarez, Isabel; Gonzalez -Alvarez, Marta; Merino, Virginia (Elsevier, 2019-03)

[EN] Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis (hydroxymethyl)phosphonium chloride as crosslinking agent to obtain covalent hydrogels based on chitosan. These ...
Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease

Hernández Teruel, Adrián; Pérez-Esteve, Édgar; González-Álvarez, Isabel; González-Álvarez, Marta; Costero Nieto, Ana María; Ferri, Daniel; Gaviña, Pablo; Merino Sanjuán, Virginia; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (American Chemical Society, 2019-06)

[EN] Silica mesoporous microparticles loaded with both rhodamine B fluorophore (S1) or hydrocortisone (S2), and capped with an olsalazine derivative, are prepared and fully characterized. Suspensions of Si and S2 in water ...
Influence of Chemical Enhancers and Iontophoresis on the In Vitro Transdermal Permeation of Propranolol: Evaluation by Dermatopharmacokinetics

Calatayud-Pascual, M.A.; Sebastian-Morelló, M.; Balaguer-Fernandez, C.; Delgado-Charro, M.B.; Lopez-Castellano, A.; Merino Sanjuán, Virginia (MDPI AG, 2018-12-07)

[EN] The aims of this study were to assess, in vitro, the possibility of administering propranolol transdermally and to evaluate the usefulness of the dermatopharmacokinetic (DPK) method in assessing the transport of drugs ...
Influence of Inter- and Intra-Batch Variability on the Sample Size Required for Demonstration of Equivalent Microstructure of Semisolid Dosage Forms

Xu, Zhengguo; Mangas-Sanjuan, Victor; Merino-Sanjuán, Matilde; Merino, Virginia; García-Arieta, Alfredo (MDPI AG, 2020-12)

[EN] Inter- and intra-batch variability of the quality attributes contribute to the uncertainty for demonstrating equivalent microstructure of post-approval changes and generic/hybrids of semisolid topical products. Selecting ...
Investigation of Different Iontophoretic Currents Profiles for Short-Term Applications in Cosmetics

Cázares-Delgadillo, J.; Planard-Luong, L.; Gregoire, S.; Serna-Jiménez, C. E.; Singhal, Mayank; Kalia, Yogeshvar N.; Merino Sanjuán, Virginia; Merino sanjuán, Matilde; Nacher Alonso, Amparo; Martinez-Gomez, M. A.; Burnier-Yalaoui, V.; Barbarat, P. (MDPI AG, 2018)

[EN] This study aimed at investigating the effect of electrical current profile upon the iontophoretic transport of (i) ascorbic acid (AA) and (ii) ellagic acid (EA), into porcine skin in vitro, and the impact of the ...
Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System

Martínez Martínez, Mayte; Rodríguez Berna, Guillermo; Gonzalez-Alvarez, Isabel; Hernández, María Jesús; Corma Canós, Avelino; Bermejo, Marival; Merino Sanjuán, Virginia; Gonzalez -Alvarez, Marta (American Chemical Society, 2018-04)

[EN] In this work, 6-phosphogluconic trisodium salt (6-PG(-)Na(+)) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan ...
Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

Di Meo, Chiara; Martínez Martínez, Mayte; Coviello, Tommasina; Bermejo, M.; Merino Sanjuán, Virginia; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Matricardi, P. (MDPI AG, 2018-11-03)

[EN] Nanohydrogels based on natural polymers, such as polysaccharides, are gaining interest as vehicles for therapeutic agents, as they can modify the pharmacokinetics and pharmacodynamics of the carried drugs. In this ...
Mesoporous silica microparticles gated with a bulky azo derivative for the controlled release of dyes/ drugs in colon

Ferri, Daniel; Gaviña, Pablo; Parra Álvarez, Margarita; Costero, Ana M.; El Haskouri, Jamal; Amorós del Toro, Pedro; Merino Sanjuán, Virginia; Teruel, Adrián H; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (The Royal Society, 2018-08)

[EN] Mesoporous silica microparticles were prepared, loaded with the dye safranin O (M-Saf) or with the drug budesonide (M-Bud) and capped by the grafting of a bulky azo derivative. Cargo release from M-Saf at different ...
New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

Hernández Teruel, Adrián; Gonzalez-Alvarez, Isabel; Bermejo, Marival; Merino Sanjuán, Virginia; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Gonzalez-Alvarez, Marta; Martínez-Máñez, Ramón (MDPI AG, 2020-09)

[EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and ...
Simultaneous controlled iontophoretic delivery of pramipexole and rasagiline in vitro and in vivo: Transdermal polypharmacy to treat Parkinson's disease

Kalaria, D.R.; Singhal, Mayank; Patravale, V.B.; Merino Sanjuán, Virginia; Kalia, Yogeshvar N. (Elsevier, 2018-06)

[EN] Effective treatment of Parkinson's disease (PD) involves administration of therapeutic agents with complementary mechanisms of action in order to replenish, sustain or substitute endogenous dopamine. The objective of ...
Smart drug delivery systems designed to improve Inflammatory Bowel Disease therapy

Hernández Teruel, Adrián (Universitat Politècnica de València, 2019-10-21)

[ES] La presente tesis doctoral titulada "Sistemas de liberacio'n controlada de fa'rmacos diseñados para mejorar el tratamiento de Enfermedad Inflamatoria Intestinal" se centra en el diseño, preparación, caracterización y ...
Statistical Methods for Quality Equivalence of Topical Products. 0.5 mg/g Betamethasone Ointment as a Case-Study

Ocaña, Jordi; Monleón-Getino, Toni; Merino, Virginia; Peris, Daniel; Soler, Lluís (MDPI AG, 2020-04)

[EN] This study examines the statistical implications, and their possible implementation, of the "Draft guideline on quality and equivalence of topical products" issued by the European Medicines Agency in 2018, with ...
Transdermal therapeutic systems for memantine delivery. Comparison of passive and iontophoretic transport

Del Rio-Sancho, S.; Serna-Jiménez, C.E.; Sebastián-Morelló, M.; Calatayud-Pascual, M.A.; Balaguer-Fernández, C.; Femenia-Font, A.; Kalia, Y.N.; MERINO SANJUÁN, VIRGINIA; Lopez-Castellano, A. (Elsevier, 2017-01-30)

[EN] Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist used in the treatment of moderate to severe dementia including the symptoms of Alzheimer's disease (AD). It is administered orally but ...