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Browsing by Author "González Cardenete, Miguel Ángel"

Now showing items 1-7 of 7

A Short and Improved Synthesis of the Antiprotozoal Abietane Diterpenoid (-)-Sugikurojin A

González-Cardenete, Miguel A; Zaragoza, Ramon J. (Georg Thieme Verlag KG, 2017-03)
Anti-Zika virus activity of several abietane-type ferruginol analogues

Sousa, Francielle T. G.; Nunes, Cristina; Malta Romano, Camila; Cerdeira Sabino, Ester; González-Cardenete, Miguel A (Universidade de São Paulo (USP), 2020)

[EN] Abietane diterpenoids are naturally occurring plant metabolites with a broad spectrum of biological effects including antibacterial. antileishmanial, antitumor, antioxidant, as well as antiinfiammatory activities. ...
Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues

González-Cardenete, Miguel A; Rivas, Fatima; Basset, Rachel; Stadler, Marco; Hering, Steffen; Padrón, José M.; Zaragozá, Ramón J.; Dea-Ayuela, Maria Auxiliadora (MDPI AG, 2021-02)

[EN] The abietane-type diterpenoids are significant bioactive compounds exhibiting a varied range of pharmacological properties. In this study, the first synthesis and biological investigation of the new abietane-diterpenoid ...
Desarrollo, escalado y validación de la síntesis del antiviral 18-(phthalimid-2-yl) ferruginol contra enfermedades tropicales causadas por los virus Dengue-2 (DENV-2) y Zika (ZIKV) de prevalencia en América Latina

González Zapata, Natalia (Universitat Politècnica de València, 2022-07-26)

[ES] En el marco de una pandemia mundial producida por el SARS-CoV-2 se reafirma la necesidad imperiosa de continuar las líneas de investigación relacionadas con infecciones producidas por virus. En zonas de América Latina ...
Semisynthetic Abietic and Dehydroabietic Acid Derivatives and Triptoquinone Epimers Interfere with LPS-Triggered Activation of Dendritic Cells

Sierra, Jelver A.; Gilchrist, Katherine; Tabares-Guevara, Jorge H.; Betancur-Galvis, Liliana; Ramírez-Pineda, José R.; González-Cardenete, Miguel A (MDPI AG, 2022-10)

[EN] Abietic acid (AA), dehydroabietic acid (DHA) and triptoquinones (TQs) are bioactive abietane-type diterpenoids, which are present in many edible vegetables and medicinal herbs with health-promoting properties. Evidence ...
Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

Hamulic, Damir; Stadler, Marco; Hering, Steffen; Padron, Jose M.; Bassett, Rachel; Rivas, Fatima; Loza-Mejia, Marco; Dea-Ayuela, M. Auxiliadora; González-Cardenete, Miguel A (American Chemical Society, 2019-04)

[EN] The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-liquiditerpenoic acid A (abietopinoic acid) (7) along with several analogues are reported. The compounds were obtained from readily ...
Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction

Zaragoza, Ramon J.; González-Cardenete, Miguel A (The Royal Society of Chemistry, 2020-04-15)

[EN] The first synthesis of C-18- and C-19-bifunctionalized abietane diterpenoids, bodinieric (or callicapoic) acids, via an aldol reaction has been developed. This key aldol reaction was very sensitive to steric hindrance. ...