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Browsing by Author "Guijarro, Ricardo"

Now showing items 1-10 of 10

A Gene Signature Combining the Tissue Expression of Three Angiogenic Factors is a Prognostic Marker in Early-stage Non-small Cell Lung Cancer

Sanmartín, Elena; Sirera Pérez, Rafael; Usó, Marta; Blasco, Ana; Gallach, Sandra; Figueroa, Santiago; Martínez, Nieves; Hernando, Cristina; Honguero, Antonio; Martorell, Miguel; Guijarro, Ricardo; Rosell, Rafael; Jantus-Lewintre, Eloisa; Camps, Carlos (Springer Verlag (Germany), 2014-02)

[EN] Background. Angiogenesis and lymphangiogenesis are key mechanisms for tumor growth and dissemination. They are mainly regulated by the vascular endothelial growth factor (VEGF) family of ligands and receptors. The aim ...
A Sonic Hedgehog Pathway Score to Predict the Outcome of Resected Non-Small Cell Lung Cancer Patients

Herreros-Pomares, Alejandro; Doria, Paula; Gallach, Sandra; Meri-Abad, Marina; Guijarro, Ricardo; Calabuig-Fariñas, Silvia; Camps, Carlos; Jantus-Lewintre, Eloisa (Springer, 2022-09-21)

[EN] Background Mutations and deregulations in components of the Hedgehog (Hh) pathway have been associated with cancer onset and tumor growth in different malignancies, but their role in non-small cell lung cancer (NSCLC) ...
Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer

Duréndez-Sáez, Elena; Calabuig-Fariñas, Silvia; Torres-Martínez, Susana; Moreno-Manuel, Andrea; Herreros-Pomares, Alejandro; Escorihuela, Eva; Mosqueda, Marais; Gallach, Sandra; Guijarro, Ricardo; Serna, Eva; Suárez-Cabrera, Cristian; Paramio, Jesús M.; Blasco, Ana; Camps, Carlos; Jantus-Lewintre, Eloisa (MDPI AG, 2022-07)

[EN] Lung cancer is a malignant disease with high mortality and poor prognosis, frequently diagnosed at advanced stages. Nowadays, immense progress in treatment has been achieved. However, the present scenario continues ...
Analysis of the immune microenvironment in resected non-small cell lung cancer: the prognostic value of different T lymphocyte markers

Usó-Marco, Marta; Jantus-Lewintre, Eloisa; Bremnes, Roy M.; Calabuig-Fariñas, Silvia; Blasco-Cordellat, Ana; Pastor, Enrique; Borreda, Irene; Molina-Pinelo, Sonia; Paz-Ares, Luis; Guijarro, Ricardo; Martorell, Miguel; Forteza, Jerónimo; Camps-Herrero, Carlos; Sirera Pérez, Rafael (Impact Journals, LLC, 2016-08-16)

[EN] The prognosis of non-small cell lung cancer (NSCLC) remains poor and heterogeneous and new biomarkers are needed. As the immune system plays a pivotal role in cancer, the study of immune-related markers may provide ...
Analysis of the prognostic role of an immune checkpoint score in resected non-small cell lung cancer patients

Usó, Marta; Jantus-Lewintre, Eloisa; Calabuig-Farinas, Silvia; Blasco, Ana; Garcia del Olmo, Eva; Guijarro, Ricardo; Martorell, Miguel; Camps, Carlos; Sirera Pérez, Rafael (Taylor & Francis, 2017)

[EN] Tumors develop mechanisms to recruit tolerogenic immune cells and to induce the expression of molecules that act as immune checkpoints. This regulation of the immune microenvironment favors immune tolerance to the ...
Characterization of Circulating T Cell Receptor Repertoire Provides Information about Clinical Outcome after PD-1 Blockade in Advanced Non-Small Cell Lung Cancer Patients

Dong, Ning; Moreno-Manuel, Andrea; Calabuig-Fariñas, Silvia; Gallach, Sandra; Zhang, Feiyu; Blasco, Ana; Aparisi, Francisco; Meri-Abad, Marina; Guijarro, Ricardo; Sirera Pérez, Rafael; Camps, Carlos; Jantus-Lewintre, Eloisa (MDPI AG, 2021-06)

[EN] Despite the success of immunotherapies in lung cancer, development of new biomarkers for patient selection is urgently needed. This study aims to explore minimally invasive approaches to characterize circulating T ...
Circulating DNA is a useful prognostic factor in patients with advanced non-small cell lung cancer

Sirera Pérez, Rafael; Bremnes, Roy M.; Cabrera, Andrea; Jantus Lewintre, Eloisa; Sanmartin, Elena; Blasco, Ana; del Pozo, Nieves; Rosell, Rafael; Guijarro, Ricardo; Galbis, Jose; Sanchez, Jose Javier; Camps, Carlos (Lippincott, Williams & Wilkins, 2011-02)

Background: Circulating DNA is observed at higher concentrations in patients with lung cancer than in controls. Qualitative and quantitative analysis of circulating DNA is a promising noninvasive tool. Our aim was to ...
MicroRNA profiling associated with non-small cell lung cancer: next generation sequencing detection, experimental validation, and prognostic value

Gallach-Garcia, Sandra; Jantus-Lewintre, Eloisa; Calabuig-Fariñas, Silvia; Montaner, David; Alonso, Sergio; Sirera Pérez, Rafael; Blasco, Ana; Usó-Marco, Marta; Guijarro, Ricardo; Martorell, Miguel; Camps-Herrero, Carlos (Impact Journals, LLC, 2017-06-22)

[EN] Background: The average five-year survival for non-small cell lung cancer (NSCLC) patients is approximately 15%. Emerging evidence indicates that microRNAs (miRNAs) constitute a new class of gene regulators in humans ...
Phase II clinical trial with gemcitabine and paclitaxel sequential monotherapy as first-line treatment for advanced non-small-cell lung cancer (SLCG 01-04)

Iranzo, Vega; Sirera Pérez, Rafael; Carrato, Alfredo; Cabrera, Andrea; Jantus, Eloísa; Guijarro, Ricardo; Sanmartín, Elena; Blasco, Ana; Gil, Mireia; Gómez Aldaraví, Lorenzo; González Larriba, José Luis; Massuti, Bertomeu; Velasco, Amalia; Provencio, Mariano; Rosell, Rafael; Camps, Carlos (Springer, 2011-06)

[EN] Background: In advanced-stage (IIIB or IV) non-small-cell lung cancer (NSCLC), combination chemotherapy has demonstrated response rates of 20% and a 1-year survival rate of 30%. We conducted a multicentre, open-label, ...
The identification of KRAS mutations at codon 12 in plasma DNA is not a prognostic factor in advanced non-small cell lung cancer patients

Camps, Carlos; Jantus Lewintre, Eloisa; Cabrera, Andrea; Blasco, Ana; Sanmartin, Elena; Gallach, Sandra; Caballero, Cristina; del Pozo, Nieves; Rosell, Rafael; Guijarro, Ricardo; Sirera Pérez, Rafael (Elsevier, 2011-06)

Qualitative analysis of circulating DNA in the blood is a promising non-invasive diagnostic and prognostic tool. Our aim was to study the association between the presence of KRAS mutations at codon 12 and several clinical ...