Self-cleaving ribozymes such as the hammerhead (HHR), the hepatitis-¿ (HDV) or the twister (Tw) motifs, are a group of small catalytic RNAs with a numerous and widespread occurrence in the genomes of organisms from all ...
Cervera Olagüe, Amelia; La Peña del Rivero, Marcos de(Oxford University Press (OUP), 2014-11)
[EN] Small self-cleaving RNAs, such as the paradigmatic Hammerhead ribozyme (HHR), have been recently found widespread in DNA genomes across all kingdoms of life. In this work, we found that new HHR variants are preserved ...
García Robles, Inmaculada; Sanchez Navarro, Jesus Angel; La Peña del Rivero, Marcos de(Walter de Gruyter, 2012)
[EN] Small self-cleaving ribozymes are a group of natural RNAs that are capable of catalyzing their own and sequence-specific endonucleolytic cleavage. One of the most studied members is the hammerhead ribozyme (HHR), a ...
Cervera, Amelia; Urbina, Denisse; La Peña del Rivero, Marcos de(BioMed Central, 2016-06-23)
[EN] Background: Catalytic RNAs, or ribozymes, are regarded as fossils of a prebiotic RNA world that have remained in
the genomes of modern organisms. The simplest ribozymes are the small self-cleaving RNAs, like the ...
[EN] Catalytic RNAs or ribozymes are considered survivors o
f an hypothetic pre
-
biotic RNA world that would
ha
ve remained conserved in today
organisms’ genomes. Most of the known catalytic RNA
are short ...