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Browsing by Author "Pedro, José R."

Now showing items 1-14 of 14

Catalytic Asymmetric Formal [3+2] Cycloaddition of 2-Isocyanatomalonate Esters and Unsaturated Imines: Synthesis of Highly Substituted Chiral g-Lactams

Espinosa, Miguel; Blay, Gonzalo; Cardona, Luz; Muñoz Roca, María Del Carmen; Pedro, José R. (John Wiley & Sons, 2017-10-20)

[EN] Unlike their isocyano and isothiocyanato analogues, isocyanato esters remain almost unexplored as formal 1,3-dipoles in asymmetric catalytic reactions. The first asymmetric formal [3+2] cycloaddition involving ...
Catalytic Diastereo- and Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols through a Vinylogous Aldol Reaction of Alkylidenepyrazolones with Trifluoromethyl Ketones

Carceller-Ferrer, Laura; González del Campo, Aleix; Vila, Carlos; Blay, Gonzalo; Muñoz Roca, María Del Carmen; Pedro, José R. (American Chemical Society, 2022-04-01)

[EN] A diastereo- and enantioselective organocatalyticaldol reaction between alkylidenepyrazolones and trifluoromethylketones leading to chiral tertiary alcohols bearing a trifluoromethylgroup is presented. The methodology ...
Catalytic Diastereo- and Enantioselective Vinylogous Mannich Reaction of Alkylidenepyrazolones to Isatin-Derived Ketimines

Carceller-Ferrer, Laura; Vila, Carlos; Blay, Gonzalo; Muñoz Roca, María Del Carmen; Pedro, José R. (American Chemical Society, 2021-10-01)

[EN] A valuable organocatalytic vinylogous Mannich reaction between alkylidenepyrazolones and isatin-derived ketimines has been successfully established. Squaramide organocatalyst, prepared from quinine, catalyzed the ...
Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines

De Munck, Lode; Vila, Carlos; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2016-12-05)

A catalytic highly enantioselective aza-Reformatsky reaction with cyclic aldimines and ketimines for the synthesis of chiral b-amino esters with good yields and excellent enantioselectivities is reported.Areadily ...
Catalytic enantioselective aza-Reformatsky reaction with seven-membered cyclic imines dibenzo[b,f][1,4]oxazepines

De Munck, Lode; Sukowski, Verena; Vila, Carlos; Muñoz Roca, María Del Carmen; Pedro, José R. (Royal Society of Chemistry, 2017-08-01)

[EN] A catalytic enantioselective aza-Reformatsky reaction is reported with cyclic dibenzo[b,f][1,4]oxazepines and ethyl iodoacetate leading to the synthesis of chiral ethyl 2-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11- ...
Catalytic Enantioselective Conjugate Alkynylation of α,β-Unsaturated 1,1,1-Trifluoromethyl Ketones with Terminal Alkynes

Sanz Marco, Amparo; Blay, Gonzalo; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2016-07-11)

The first catalytic enantioselective conjugate alkynylation of α,β-unsaturated 1,1,1-trifluoromethyl ketones has been carried out. Terminal alkynes and 1,3-diynes were treated with trifluoromethyl ketones in the presence ...
Efficient Synthesis of 5-Chalcogenyl-1,3-oxazin-2-ones by Chalcogen-Mediated Yne Carbamate Cyclisation: An Experimental and Theoretical Study

Monleón, Alicia; Blay, Gonzalo; Domingo, Luis R.; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley-VCH Verlag, 2015-02)

A very efficient synthesis of 5-chalcogenyl-1,3-oxazin-2-ones has been accomplished by the chalcogen-mediated yne-carbamate cyclisation of chiral, non-racemic N-Cbz-protected propargylic amines using PhXY (X = Se, S, Te; ...
Metal-Free Diastereo- and Enantioselective Dearomative Formal [3+2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters

Laviós, Adrian; Sanz-Marco, Amparo; Vila, Carlos; Muñoz Roca, María Del Carmen; Pedro, José R.; Blay, Gonzalo (American Chemical Society, 2022-03-25)

[EN] The diastereo- and enantioselective dearomative formal [3 + 2] cycloaddition of 2-nitrobenzofurans and alpha-aryl-alpha isocyanoacetate esters provides tricyclic compounds bearing the 3a,8b-dihydro-1H-benzofuro[2,3-c]pyrrole ...
Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

Montesinos Magraner, Marc; Vila, Carlos; Cantón, Rubén; Blay, Gonzalo; Fernández, Isabel; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2015)

A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a ...
Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

Amr, Fares Ibrahim; Vila, Carlos; Blay, Gonzalo; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2016-05-19)

A quinine-derived thiourea catalysed the enantioselective addition of 4-substituted pyrazolones to isatin-derived ketimines, providing a variety of aminooxindole-pyrazolone adducts containing congested vicinal ...
Organocatalytic Enantioselective Friedel-Crafts Alkylation of 1-Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate

Montesinos Magraner, Marc; Vila, Carlos; Blay, Gonzalo; Fernández, Isabel; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2015-10-12)

An organocatalytic enantioselective Friedel–Crafts alkylation of a series of substituted 1- naphthol derivatives and activated phenols with ethyl trifluoropyruvate, catalyzed by a quinine-derived squaramide, is presented. ...
Organocatalytic Enantioselective Friedel-Crafts Aminoalkylation of Indoles in the Carbocyclic Ring

Montesinos Magraner, Marc; Vila, Carlos; Rendón Patiño, Alejandra; Blay, Gonzalo; Fernández, Isabel; Muñoz Roca, María del Carmen; Pedro, José R. (American Chemical Society, 2016)

The first general catalytic method for the, so far elusive, enantioselective Friedel−Crafts functionalization of indoles in the carbocyclic ring is presented. This transformation contrasts with the usual tendency of these ...
Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

Vila, Carlos; Amr, Fares Ibrahim; Blay, Gonzalo; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley, 2016-05-20)

An efficient one-pot asymmetric synthesis of pyrazoles bearing a chiral quaternary stereocenter has been developed. Quinine-derived thiourea catalyzed the enantioselective addition of pyrazolones to isatin-derived ketimines, ...
Synthesis of Densely Functionalised 5-Halogen-1,3-oxazin-2-ones byHalogen-Mediated Regioselective Cyclisation of N-Cbz-ProtectedPropargylic Amines: A Combined Experimental and Theoretical Study

Monleon, Alicia; Blay, Gonzalo; Domingo, Luis R.; Muñoz Roca, María del Carmen; Pedro, José R. (Wiley-VCH Verlag, 2013-10-25)

A very efficient synthesis of 5-halogen-1,3-oxazin-2-ones has been accomplished by the halocyclisation reaction of chiral nonracemic N-carbobenzyloxy (N-Cbz)-protected propargylic amines by using I-2, Br-2 and Cl-2 as ...