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Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues

González-Cardenete, Miguel A; Rivas, Fatima; Basset, Rachel; Stadler, Marco; Hering, Steffen; Padrón, José M.; Zaragozá, Ramón J.; Dea-Ayuela, Maria Auxiliadora (MDPI AG, 2021-02)

[EN] The abietane-type diterpenoids are significant bioactive compounds exhibiting a varied range of pharmacological properties. In this study, the first synthesis and biological investigation of the new abietane-diterpenoid ...
Discovery of Novel Bioactive Tanshinones and Carnosol Analogues against Breast Cancer

González-Cardenete, Miguel A; González-Zapata, Natalia; Boyd, Lucinda; Rivas, Fatima (MDPI AG, 2023-02)

[EN] The abietane diterpenoids ferruginol (1), tanshinone IIA (3), and carnosol (4) are well-known for their interesting pharmacological properties, including antitumor, similar to other natural and semisynthetic abietanes. ...
Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

Hamulic, Damir; Stadler, Marco; Hering, Steffen; Padron, Jose M.; Bassett, Rachel; Rivas, Fatima; Loza-Mejia, Marco; Dea-Ayuela, M. Auxiliadora; González-Cardenete, Miguel A (American Chemical Society, 2019-04)

[EN] The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-liquiditerpenoic acid A (abietopinoic acid) (7) along with several analogues are reported. The compounds were obtained from readily ...

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