Currently available keratoprosthesis models (nonbiological corneal substitutes) have a less than 75% graft survival rate at 2 years. We aimed at developing a model for keratoprosthesis based on the use of poly(ethyl acrylate) ...
Marin Paya, Juan Carlos; Díaz Benito, Blanca; Amaro Martins, Luis; Clara Trujillo, Sandra; Cordón, Lourdes; Lanceros-Mendez, Senentxu; Gallego Ferrer, Gloria; Sempere, Amparo; Gómez Ribelles, José Luís(Universitat Politècnica de València, 2021-12-14)
The development of three-dimensional environments to mimic the in vivo cellular response is a problem in the building of disease models. This study aimed to synthesize and validate three-dimensional support for culturing ...
Marín-Payá, Juan Carlos; Díaz-Benito, Blanca; Amaro Martins, Luis; Clara Trujillo, Sandra; Cordón, Lourdes; Lanceros-Méndez, Senentxu; Gallego Ferrer, Gloria; Sempere, Amparo; Gómez Ribelles, José Luís(MDPI AG, 2021-12)
[EN] The development of three-dimensional environments to mimic the in vivo cellular response is a problem in the building of disease models. This study aimed to synthesize and validate three-dimensional support for culturing ...
[EN] Polymer ceramic composites obtained as the result of a mineralization process hold great promise for the future of tissue engineering. Simulated body fluids (SBFs) are widely used for the mineralization of polymer ...
Clara-Trujillo, Sandra; Marin-Paya, Juan Carlos; Cordón, Lourdes; Sempere, Amparo; Gallego Ferrer, Gloria; Gómez Ribelles, José Luís(Elsevier, 2019-05-01)
[EN] Stem cells reside in niches, specialized microenvironments that sustain and regulate their fate. Extracellular matrix (ECM), paracrine factors or other cells are key niche regulating elements. As the conventional 2D ...
Sancho-Tello, María; Forriol, Francisco; Martín de Llano, José J.; Antolinos Turpín, Carmen María; Gómez-Tejedor, José-Antonio; Gómez Ribelles, José Luís; Carda, Carmen(Wichtig Publishing, 2017)
[EN] Purpose: To study the influence of scaffold properties on the organization of ¿in vivo¿
cartilage regeneration. Our hypothesis is that stress transmission to the cells seeded
inside the scaffold pores or surrounding ...
[EN] In order to advance towards more sustainable electronics generation, natural polymers with tailored dielectric response are essential. In this search, the combination of bio-based materials with active fillers in ...
Lebourg, Myriam Madeleine; Martínez Díaz, S.; Garcia Giralt, Natalia; Torres Claramunt, R.; Gómez-Tejedor, José Antonio; Gómez Ribelles, José Luís; Vila Canet, G; Monllau, J.C.(SAGE Publications (UK and US), 2014-05)
Polycaprolactone scaffolds modified with cross-linked hyaluronic acid were prepared in order to establish whether a
more hydrophilic and biomimetic microenvironment benefits the progenitor cells arriving from bone marrow ...
Martínez Ramos, Cristina; Vallés Lluch, Ana; García Verdugo, José Manuel; Gómez Ribelles, José Luís; Barcia Albacar, Juan Antonio; Baiget Orts, María Amparo; Soria Lopez, Jose Miguel; Monleón Pradas, Manuel(Wiley: 12 months, 2012-12)
Scaffolds with aligned channels based on acrylate copolymers, which had previously demonstrated good com- patibility with neural progenitor cells were studied as coloniz- able structures both in vitro with neural progenitor ...
Garcia-Giralt, N.; García Cruz, Dunia Mercedes; Nogues, X.; Escobar Ivirico, Jorge Luis; Gómez Ribelles, José Luís(The Royal Society of Chemistry, 2013)
[EN] Chondrocytes are frequently cultured embedded in gels that provide them with a three-dimensional environment. Nevertheless cells in these constructs cannot remodel their neighbourhood when producing their own extracellular ...
Gilabert-Chirivella, Eduardo; Pérez-Feito, Ricardo; Ribeiro, Clarisse; Ribeiro, Sylvie; Correia, Daniela M.; González-Martín, Maria Luisa; Manero, Jose Maria; Lanceros-Mendez, S.; Ferrer, GG; Gómez Ribelles, José Luís(Elsevier, 2017-10)
[EN] Titanium and its alloys are widely used in medical implants because of their excellent properties. However, bacterial infection is a frequent cause of titanium-based implant failure and also compromises its osseointegration. ...
Pandis, Christos; Madeira, Sara; Matos, Joana; Kyritsis, Apostolos; Mano, Joao; Gómez Ribelles, José Luís(Elsevier, 2014-09-01)
Chitosan-silica porous hybrids were prepared by a novel strategy in order to improve the mechanical properties of chitosan (CHT) in the hydrogel state. The inorganic silica phase was introduced by sal-gel reactions in ...
[EN] The aim of this study was to evaluate whether mechanical stimulation helps to modulate the redifferentiation of human chondrocytes on adhesive 3D substrates. In a previous work, it was shown that chondrocytes seeded ...
The aim of this work is to compare the effect of hydroxyapatite (HAp) or bioglass (BG) nanoparticles in a polycaprolactone composite scaffold aimed to bone regeneration. To allow a comparison of the influence of both types ...
Guerra Ojeda, Solanye Jacqueline(Universitat Politècnica de València, 2015-02-25)
[EN] Amphiphilic polyurethanes were synthesized from higth molecular eigth PEG and PCL diols as polymer segments and hexamethylene diisocyanate (HMDI) as binding agent. From these materials, biodegradable membranes were ...
Costa, Carlos M.; Tamano Machiavello, M.N.; Gómez Ribelles, José Luís; Lanceros Mendez, Senen(Springer Verlag, 2013-05)
Polymer blends based on poly(vinylidene fluoride-co-trifluoroethylene) copolymers, P(VDF-TrFE), and poly(ethylene oxide), PEO, with varying compositions have been prepared by solvent casting. In this way, P(VDF-TrFE) ...
Ródenas Rochina, Joaquín; Kelly, Daniel John; Gómez Ribelles, José Luís; Lebourg, Myriam Madeleine(IOP Publishing, 2016)
[EN] Mechanical cues such as hydrostatic pressure (HP) are known to regulate mesenchymal stem cell (MSC) differentiation. The fate of such cells is also strongly influenced by their substrate. The objective of this study ...
Molina Mateo, José; Torregrosa Cabanilles, Constantino; Sabater i Serra, Roser; Meseguer Dueñas, José María; Gómez Ribelles, José Luís(Elsevier, 2013-02-15)
The heterogeneity of local segmental dynamics in a polymer system is analyzed by computer simulation with the Bond Fluctuation Model. A different approach is proposed based on the concept of Dynamically Accessible Volume ...
Sabater i Serra, Roser; Torregrosa Cabanilles, Constantino; Meseguer Dueñas, José María; Gómez Ribelles, José Luís; Molina Mateo, José(Elsevier, 2014-10-15)
The bond fluctuation model has been used to simulate the adsorption process of a single long polymer chain on an adsorbing surface. Simulations start at high temperature with the chain in an equilibrium coil structure. The ...
Sabater i Serra, Roser; Torregrosa Cabanilles, Constantino; Meseguer Dueñas, José María; Gómez Ribelles, José Luís; Molina Mateo, José(Elsevier, 2012-07-01)
The conformation of a single long polymer chain has been modelled using the Bond Fluctuation Model. The interaction between non-bonded segments has been introduced in the model by means of a Lennard-Jones potential while ...