Calatayud Sánchez, Alba(Universitat Politècnica de València, 2016-09-02)
[ES] La mitocondria es un orgánulo altamente dinámico, la actividad mitocondrial es muy sensible al entorno, es decir a las condiciones metabólicas celulares. Existen procesos moleculares bien descritos que garantizan el ...
Muñoz Blat, Irene(Universitat Politècnica de València, 2018-09-18)
[ES] La mitofagia es un tipo específico de autofagia que tiene un papel esencial en el
mantenimiento de la homeostasis mitocondrial. Es además un proceso que asegura el
mantenimiento de la calidad mitocondrial en situaciones ...
Vanacloig-Pedrós, Mª Elena; Lozano-Pérez, Carlos; Alarcon, B.; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(American Society for Biochemistry and Molecular Biology, 2019-08-30)
[EN] Pleiotropic drug resistance arises by the enhanced extrusion of bioactive molecules and is present in a wide range of organisms, ranging from fungi to human cells. A key feature of this adaptation is the sensitive ...
Timón Gómez, Alba(Universitat Politècnica de València, 2016-05-30)
[EN] Eukaryotic cells adapt to environmental changes ("stress") through signal transduction pathways which coordinate complex adaptive responses. Mitochondria are able to respond to different external stimuli in a dynamic ...
González Cantó, Eva(Universitat Politècnica de València, 2018-09-18)
[ES] Las células eucariotas se adaptan continuamente a estreses abióticos como por ejemplo el
estrés osmótico o el estrés oxidativo. Ambos estreses están fisiológicamente relacionados, y en
estudios anteriores se ha ...
Manzanares-Estreder, Sara; Espí Bardisa, Joan; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(Blackwell Publishing, 2016)
[EN] Peroxisomes are dynamic organelles and the sole location for fatty acid ß-oxidation in yeast cells. Here, we report that peroxisomal function is crucial for the adaptation to salt stress, especially upon sugar limitation. ...
Arévalo Domínguez, Cristina(Universitat Politècnica de València, 2019-09-03)
[ES] La levadura es un modelo celular para comprender los mecanismos moleculares que emplean
las células eucariotas para adaptarse a estreses químicos. Un importante mecanismo de
señalización es el reconocimiento directo ...
Manzanares Estreder, Sara(Universitat Politècnica de València, 2015-07-01)
[EN] In the present work the physiological consequences of sphingolipid degradation was studied, which is conserved between yeast and humans. In this metabolic pathway, sphingosine–1–phosphate and dihydrosphingosine are ...
Pascual-Ahuir Giner, María Desamparados; Manzanares-Estreder, Sara; Proft, Markus(Hindawi Limited, 2017)
[EN] Peroxisomes and mitochondria are the main intracellular sources for reactive oxygen species. At the same time, both organelles are critical for the maintenance of a healthy redox balance in the cell. Consequently, ...
Juncos Bombín, Adrián Darío(Universitat Politècnica de València, 2016-06-22)
[EN] Fungi (yeasts) and human cells have developed defense systems against a wide variety of chemical compounds (toxins, drugs, etc). These adaptive responses are known as the "Pleiotropic Drug Resistance (PDR)". Activation ...
Timón Gómez, Alba; Sanfeliu-Redondo, D.; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(Frontiers Media SA, 2018)
[EN] Repair and removal of damaged mitochondria is a key process for eukaryotic cell homeostasis. Here we investigate in the yeast model how different protein complexes of the mitochondrial electron transport chain are ...
Martínez Montañés, Fernando Vicente; Pascual-Ahuir Giner, María Desamparados; Proft ., Markus Hans(WILEY-BLACKWELL PUBLISHING, INC, 2010)
[EN] Hyperosmotic stress triggers a complex adaptive response that is dominantly regulated by the Hog1 MAP kinase in yeast. Here we characterize a novel physiological determinant of osmostress tolerance, which involves the ...
Garrido-Huarte, José Luis; Fita-Torró, Josep; Viana, Rosa; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(Frontiers Media SA, 2023-04-03)
[EN] Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small accessory proteins ORF3a and ORF7a have ...
Manzanares-Estreder, Sara; Pascual-Ahuir Giner, María Desamparados; Proft, Markus(Hindawi Limited, 2017)
[EN] Sphingolipids are regulators of mitochondria-mediated cell death in higher eukaryotes. Here, we investigate how changes in sphingolipid metabolism and downstream intermediates of sphingosine impinge on mitochondrial ...
Rienzo, Alessandro; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(Wiley, 2012-06)
[EN] A destabilized version of firefly luciferase was used in living yeast cells as a real-time reporter for gene expression. This highly sensitive and non-invasive system can be simultaneously used upon many different ...
Pascual-Ahuir Giner, María Desamparados; Vanacloig Pedrós, María Elena; Proft, Markus Hans(MDPI AG, 2014-05)
Mycotoxins are important food contaminants and a serious threat for human nutrition. However, in many cases the mechanisms of toxicity for this diverse group of metabolites are poorly understood. Here we apply live cell ...