CNS damages are often irreversible since neurons of the central nervous system are unable to regenerate after an injury. As a new strategy within the nervous system tissue engineering, multifunctional systems based on two ...
Martínez Ramos, Cristina; Vallés Lluch, Ana; García Verdugo, José Manuel; Gómez Ribelles, José Luís; Barcia Albacar, Juan Antonio; Baiget Orts, María Amparo; Soria Lopez, Jose Miguel; Monleón Pradas, Manuel(Wiley: 12 months, 2012-12)
Scaffolds with aligned channels based on acrylate copolymers, which had previously demonstrated good com- patibility with neural progenitor cells were studied as coloniz- able structures both in vitro with neural progenitor ...
[EN] A set of elastomeric scaffolds with a well defined porous structure was prepared with a template leaching procedure and coated with hyaluronic acid solutions. Depending on the coating process parameters the hyaluronic ...
Composite scaffolds of poly(l-lactide acid) and hydroxyapatite are of great interest in bone tissue engineering, but their mechanical properties are typically inferior to scaffolds of pure poly(l-lactide acid) due to ...
Rocamonde, Brenda; Paradells, Sara; Garcia Esparza, M. Angeles; Sanchez Vives, Mavi; Sauro, Salvatore; Martínez-Ramos, Cristina; Monleón Pradas, Manuel; Soria, Jose Miguel(Taylor & Francis, 2016)
[EN] Primary objective: The aim of this study was to investigate the reparative potential of a polymeric scaffold designed for brain tissue repair in combination with lipoic acid.
Research design: Histological, cytological ...
Vallés Lluch, Ana; Arnal Pastor, María Pilar; Martínez Ramos, Cristina; Vilariño Feltrer, Guillermo; Vikingsson, Line; Castells Sala, Carla; Semino, Carlos Eduardo; Monleón Pradas, Manuel(Elsevier, 2013-12)
[EN] Some of the problems raised by the combination of porous scaffolds and self-assembling peptide (SAP)
gels as constructs for tissue engineering applications are addressed for the first time. Scaffolds of poly(-
ethyl ...
[EN] Novel composites of poly(methyl methacrylate) with silanized micro and nanohydroxyapatite (HA) particles were prepared. Coralina((R)) HA was the MicroHA filler and synthetic NanoHA was the reinforcement. The influence ...
Vilariño Feltrer, Guillermo(Universitat Politècnica de València, 2015-12-14)
[EN] Since a considerable number of factors limit or prevent the autonomous regeneration of injured or degenerated tracts in the nervous system, its effective restoration is a rare phenomenon. Therefore, conventional ...
[EN] We address the production of structures intended as conduits made from natural biopolymers, capable of promoting the regeneration of axonal tracts. We combine hyaluronic acid (HA) and silk fibroin (SF) with the aim ...
[EN] The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from ...
Due to the attractive properties of poly(l-lactic acid) (PLLA) for tissue engineering, the aim was to determine the growth and differentiation capacity of mesenchymal stromal cells (MSCs) in PLLA scaffolds and their potential ...
Escobar Ivirico, Jorge Luis; Beaumont, Marco; García Cruz, Dunia Mercedes; Gómez Pinedo, Ulises; Monleón Pradas, Manuel(SAGE Publications, 2013)
[EN] In this study, the toxicity of 4-hydroxytamoxifen (4-OHT) on human Schwann cells (HSCs) was evaluated. Substantial alterations in the cell morphology and viability were observed at 4-OHT concentrations higher than 3 ...
Morales Hurtado, Marina(Universitat Politècnica de València, 2013-02-27)
[ES] En el presente trabajo se ha desarrollado un nuevo biomaterial basado en un hidrogel de ácido hialurónico reforzado mediante fibras micro y nanométricas obtenidas mediante la técnica de electrohilado. Este material ...
Quesada Dorigné, Sergio(Universitat Politècnica de València, 2015-09-18)
[EN] Controled release of Rolipram by means of a microsphere system, enhancing neural tissue regeneration following a spinal cord injury.Microspheres properties, loading and drug release kinetics evaluation
Serrano Requena, Sara(Universitat Politècnica de València, 2021-10-08)
[ES] Las patologías que se derivan en el sistema nervioso llevan asociadas la dificultad de regeneración del propio tejido, especialmente cuando se habla del Sistema Nervioso Central (SNC). Es debido a esta problemática ...
García Jiménez, Irene(Universitat Politècnica de València, 2020-09-08)
[ES] La problemática asociada a las patologías del sistema nervioso viene del limitado potencial de regeneración de los tejidos nerviosos, y especialmente del SNC. Las lesiones en estos tejidos suponen un importante problema ...
Villa Sánchez, Camila Alejandra(Universitat Politècnica de València, 2021-09-17)
[EN] Central and peripheral nervous system injuries such as nerve injuries and spinal cord injury are
diseases with a high incidence today due to trauma situations, the consequences of these
traumas are high in the quality ...
Lapeña Luzón, Tamara(Universitat Politècnica de València, 2017-09-05)
[ES] Las lesiones de la médula espinal son un problema que presenta múltiples consecuencias a
nivel sanitario, social y económico. Estas alteraciones provocan una pérdida de la función
motora y sensorial por debajo de ...