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Listar por autor "Andreu Ros, María Inmaculada"

Mostrando ítems 21-40 de 55

Evaluación de un posible mecanismo para la fotoalergia causada por el filtro solar octocrileno

Rivera Rincón, Mary Julieth (Universitat Politècnica de València, 2015-09-18)
Evaluación del potencial fotoquímico y fotobiológico de los inhibidores de la poli (ADP-ribosa) polimerasa

Mateos Pujante, Alejandro (Universitat Politècnica de València, 2023-09-07)

[ES] En la presente tesis doctoral se ha desarrollado una metodología multidisciplinar para la evaluación del potencial fotoquímico y fotobiológico in vitro de los fármacos inhibidores de la poli (ADP-ribosa) polimerasa ...
Evaluation of phototoxicity induced by the anticancer drug rucaparib

Mateos-Pujante, Alejandro; Jiménez Molero, María Consuelo; Andreu, Inmaculada (Nature Publishing Group, 2022-03-02)

[EN] Rucaparib (RCP) is a potent selective inhibitor of both PARP-1 and PARP-2 enzymes that induces synthetic lethality in cancer cells. It is used for the treatment of breast and ovarian tumors harboring deleterious ...
Examples for biological reactivity involving free radicals followed by CIDNP

Andreu Ros, María Inmaculada; Neshchadin, Dmytro; Batchelor, Stephen N.; Miranda Alonso, Miguel Ángel; Gescheidt, Georg (Taylor & Francis, 2013-10-01)

It is shown how chemically induced dynamic nuclear polarisation (CIDNP) spectroscopy is able to efficiently complement electron paramagnetic resonance (EPR), when molecular transformations of free radical pairs are ...
Fluoroquinolone photodegradation influences specific basophil activation

Mayorga, Cristobalina; Andreu Ros, María Inmaculada; Aranda, Ana; Doña, Inmaculada; Montañez, M. Isabel; Blanca-López, Natalia; Ariza, Adriana; Nuin Plá, Neus Edurne; Blanca, Miguel; Miranda Alonso, Miguel Ángel; Torres, Mª José (Karger, 2013)

Fluoroquinolones (FQs) are photoreactive drugs, but it is not known whether laboratory light exposure can influence the induction of photoproducts and modify in vitro test results. The basophil activation test (BAT) has ...
Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole

Martínez, Carmen; Andreu Ros, María Inmaculada; Amo, Gemma; Miranda Alonso, Miguel Ángel; Esguevillas, Gara; Torres, María José; Blanca López, Natalia; Blanca, Miguel; Garcia Martin, Elena; Agúndez, José A.G. (Elsevier, 2014-12-01)

Metamizole is a pain-killer drug that has been banned in some countries because of its toxicity, but it is still used in many countries due to its effective analgesic and antispasmodic properties. Although large variability ...
Hydrogen Abstraction from the C15 Position of the Cholesterol Skeleton

Palumbo, Fabrizio; Andreu Ros, María Inmaculada; Brunetti, M.; Schmallegger, Max; Gescheidt, Georg; Neshchadin, Dmytro; Miranda Alonso, Miguel Ángel (American Chemical Society, 2019-12-06)

[EN] Cholesterol (Ch) is an integral part of cell membrane, where it is prone to oxidation. In humans, oxidation of Ch is commonly linked to various pathologies like Alzheimer's disease, atherosclerosis, and even cancer, ...
Immediate hypersensitivity reactions to ibuprofen and other arylpropionic acid derivatives

Blanca-López, Natalia; Pérez-Alzate, D.; Andreu Ros, María Inmaculada; Doña, Inmaculada; Agundez, Javier A.; García-Martín, Elena; Salas, M.; Miranda Alonso, Miguel Ángel; Torres, M. J.; Cornejo-Garcia, J.A.; Blanca, M.; Canto, G. (Wiley, 2016-07)

[EN] Background: Although ibuprofen and other arylpropionic acid derivatives (APs) are the most common medicines involved in hypersensitivity drug reactions (HDRs) to NSAIDs, no patient series studies have been performed ...
In vitro assessment of the photo(geno)toxicity associated with Lapatinib, a Tyrosine Kinase inhibitor

García-Laínez, G.; Vayá Pérez, Ignacio; Marín, Mª Pilar; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Springer-Verlag, 2021-01)

[EN] The epidermal growth factor receptors EGFR and HER2 are the main targets for tyrosine kinase inhibitors (TKIs). The quinazoline derivative lapatinib (LAP) is used since 2007 as dual TKI in the treatment of metastatic ...
In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones

Aranda, A.; Mayorga, C.; Ariza, A.; Doña, I.; Rosado, A.; Blanca-López, N.; Andreu Ros, María Inmaculada; Torres, M.J. (Wiley-Blackwell, 2011)

Background: Hypersensitivity IgE-mediated reactions to quinolones are not easy to diagnose, with skin testing inducing false positive results. The aim of the study was to evaluate the in vitro-specific IgE response in ...
Influence of drug encapsulation within mixed micelles on the excited state dynamics and accessibility to ionic quenchers

Nuin Plá, Neus Edurne; Gómez Mendoza, Miguel; Marín García, Mª Luisa; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013-08-15)

Photophysical techniques, specifically time-resolved fluorescence and laser flash photolysis, have proven to be noninvasive, straightforward, and valuable tools to demonstrate how drug encapsulation into biomimetic mixed ...
Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods

Limones Herrero, Daniel; Palumbo, Fabrizio; Vendrell Criado, Victoria; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (Elsevier, 2020-02-05)

[EN] Transient absorption spectroscopy in combination with in silico methods has been employed to study the interactions between human serum albumin (HSA) and the anti-psychotic agent chlorpromazine (CPZ) as well as its ...
Mechanistic Studies on the Photoallergy Mediated by Fenofibric Acid: Photoreactivity with Serum Albumins

Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Monje-López, Vicente Tomás; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2016-01)

[EN] The photoreactivity of fenofibric acid (FA) in the presence of human and bovine serum albumins (HSA and BSA, respectively) has been investigated by steady-state irradiation, fluorescence, and laser flash photolysis ...
Multiple nonsteroidal anti-inflammatory drug hypersensitivity without hypersensitivity to aspirin

Perez-Sanchez, Natalia; Bogas, Gador; Cornejo-Garcia, José Antonio; Andreu Ros, María Inmaculada; Doña, Inmaculada; Perez-Alzate, Diana; Blanca-López, Natalia (Elsevier, 2016)

Subjects developing anaphylaxis or urticaria/angioedema after chemically unrelated nonsteroidal antiinflammatory drug intake should not be classified as cross-hypersensitive unless they do not tolerate acetyl salicylic ...
Naphtalene triplet excited state as a probe for the assessment of drug distribution in binary protein systems

Pérez Ruiz, Raúl; Alonso Ruiz, Rafael; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2011-04-21)

[EN] Three drugs containing the naphthalene (NP) chromophore, namely, naproxen (NPX), propranolol (PPN), and cinacalcet (CIN), but with different affinities toward serum albumins (SAs) and alpha-1-acid glycoproteins (AAGs) ...
New photoactive compounds to probe cholic acid and cholesterol inside mixed micelles

Nuin Plá, Neus Edurne; Gómez Mendoza, Miguel; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013-01-18)

New photoactive dyads have been synthesized by derivatization of cholic acid (CA) or cholesterol (Ch). These compounds have proven to be efficient tools to monitor incorporation of CA and Ch to mixed micelles (MM) and to ...
Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA

Aparici-Espert, Maria Isabel; García-Laínez, G.; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (American Chemical Society, 2018-03)

[EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced ...
Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

García -Laínez, Guillermo; Ana M Marínez-Reig; Limones Herrero, Daniel; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2018)

[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order ...
Photomutagenicity of chlorpromazine and its N-demethylated metabolites assessed by NGS

Agúndez, Jose A.G.; García-Martín, Elena; Garcia-Lainez, Guillermo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Nature Publishing Group, 2020-04-23)

[EN] The human genome is constantly attacked by endogenous and exogenous agents (ultraviolet light, xenobiotics, reactive oxygen species), which can induce chemical transformations leading to DNA lesions. To combat DNA ...
Photooxygenation mechanisms in naproxen-amino acid linked systems

Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2014)

The photooxygenation of model compounds containing the two enantiomers of naproxen (NPX) covalently linked to histidine (His), tryptophan (Trp) and tyrosine (Tyr) has been investigated by steady state irradiation, ...