Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús(Institute of Electrical and Electronics Engineers, 2020-01)
[EN] Kinetic (i.e., dynamic) semimechanistic models based on the first principles are particularly important in systems and synthetic biology since they can explain and predict the functional behavior that emerges from the ...
[EN] Synthetic biology is reaching the situation where tuning devices by hand is no longer possible due to the complexity of the biological circuits being designed. Thus, mathematical models need to be used in order, not ...
[EN] Synthetic biology exploits the of mathematical modeling of synthetic circuits both to predict the behavior of the designed synthetic devices, and to help on the selection of their biological coin portents. The increasing ...
Santos-Navarro, Fernando Nóbel; Vignoni, Alejandro; Boada-Acosta, Yadira Fernanda; Picó, Jesús(American Chemical Society, 2021-12-17)
[EN] Models of gene expression considering host-circuit interactions are relevant for understanding both the strategies and associated trade-offs that cell endogenous genes have evolved and for the efficient design of ...
[EN] Specific kinetic rates are key variables regarding metabolic activity in bioprocesses. They are non-linear functions of concentrations and operating conditions and therefore of difficult access for process control. ...
[EN] This paper addresses the problem of coordinating dynamical systems with possibly different dynamics (e.g., linear and nonlinear, different orders, constraints, etc.) to achieve some desired collective behavior under ...
[EN] This paper addresses the estimation of specific growth rate of microorganisms in bioreactors using sliding observers. In particular, a second-order sliding observer based on biomass concentration measurement is proposed. ...
Picó Marco, Jesús Andrés; Picó Marco, Enrique; Vignoni, Alejandro; De Battista, Hernán(International Federation of Automatic Control, 2013)
The super-twisting algorithm (STA) has become the prototype of second-order sliding mode algorithm.
It achieves finite time convergence by means of a continuous action, without using information about
derivatives of the ...