[EN] Colon targeted drug delivery is highly relevant not only to treat colonic local diseases but also for systemic therapies. Mesoporous silica nanoparticles (MSNs) have been demonstrated as useful systems for controlled ...
[EN] We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved ...
Muniesa Lajara, Carlos; Vicente Vilas, Victor; Quesada Vilar, Manuel; SAEZ-ATIENZAR, SARA; BLESA-BLESA, JOSE RAFAEL; Abasolo, Ibane; Fernández, Yolanda; Botella Asuncion, Pablo(Royal Society of Chemistry, 2013)
[EN] We report the design, synthesis, characterization and in vitro testing of a novel nanodrug based on a covalent linking model that allows intracellular controlled release of the pharmaceutical payload. A new synthetic ...
Ferrández Rives, Mariola(Universitat Politècnica de València, 2016-09-02)
[ES] El objetivo del proyecto es el desarrollo de membranas de hidrogel producidas por electrohilado desde las que se pueda liberar un fármaco. De cara a dotar al gel de consistencia mecánica y para modular la cinética de ...
[EN] Here, we present the design of smart nano-devices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au-mesoporous ...
Hernández-Montoto, Andy; Llopis-Lorente, Antoni; Gorbe, Mónica; Terrés-Haro, José Manuel; Cao Milán, Roberto; Díaz de Greñu-Puertas, Borja; Alfonso-Navarro, María; Ibáñez Civera, Francisco Javier; Marcos Martínez, María Dolores; Orzaez, Mar; Villalonga, R.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix(John Wiley & Sons, 2019-05-27)
[EN] Janus gold nanostar-mesoporous silica nanoparticle (AuNSt-MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was ...
Marcelo, Gonçalo A.; Galhano, Joana; Robalo, Tiago T.; Cruz, Maria Margarida; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Duarte, Maria Paula; Capelo-Martínez, José Luis; Lodeiro, Carlos; Oliveira, Elisabete(MDPI AG, 2022-10)
[EN] Cancer-related opportunistic bacterial infections are one major barrier for successful clinical therapies, often correlated to the production of genotoxic factors and higher cancer incidence. Although dual anticancer ...
Muniesa Lajara, Carlos(Universitat Politècnica de València, 2013-06-14)
El desarrollo de nanofármacos aplicados en terapias frente al cáncer es
un prometedor campo de la biomedicina en el cual se entrecruzan diferentes
disciplinas científicas como la biología, la ciencia de los materiales, ...
[EN] An increase of bone diseases incidence has boosted the study of ceramic biomaterials as potential osteo-inductive scaffolds. In particular, mesoporous bioactive glasses have demonstrated to possess a broad application ...
Vivo Llorca, Gema(Universitat Politècnica de València, 2021-07-26)
[ES] La presente tesis doctoral titulada "Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications" se centra en el diseño, síntesis, caracterización y evaluación de ...
[EN] Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic ...
[EN] Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC. Nevertheless, rapid navitoclax resistance onset has been ...
García-Fernández, Alba; Vivo-Llorca, Gema; Sancho, Mónica; García-Jareño, Alicia Belén; Ramírez-Jiménez, Laura; Barber-Cano, Eloísa; Murguía, Jose R.; Orzaez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón(The Royal Society of Chemistry, 2022-07)
[EN] In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of ...
[EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and ...
Basar, A. O.; Castro, S.; Torres-Giner, S.; Lagaron, J. M.; Turkoglu Sasmazel, H.(Elsevier BV, 2017-12-01)
[EN] In the present study, a single and binary Ketoprofen-loaded mats of ultrathin fibers were developed by electrospinning and their physical properties and drug release capacity was analyzed. The single mat was prepared ...
[EN] The main electrospinning parameters, i.e., polymer concentration in the injectable solution, solvents used and their proportion, flow rate, voltage and distance to collector were herein systematically modified to ...
[EN] The administration of cytotoxic drugs in classical chemotherapy is frequently limited by water solubility, low plasmatic stability, and a myriad of secondary effects associated with their diffusion to healthy tissue. ...
Abarca Lázaro, Javier(Universitat Politècnica de València, 2018-02-09)
The prospects of treatment for neurodegenerative diseases require tackling the issue that the blood-brain barrier signifies for the appropriate drug delivery towards the central nervous system. Through the last decades ...
[EN] Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the ...
Ultimo, Amelia; Giménez Morales, Cristina; BARTOVSKY, PAVEL; Aznar, Elena; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Amoros del Toro, Pedro Jose; Bernardo, Ana R.; Martínez-Máñez, Ramón; Jiménez Lara, Ana M.; Murguía, Jose R.(Wiley, 2016-01-26)
The authors describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for ...