Antón García, Pablo Antonio(Universitat Politècnica de València, 2015-09-04)
[ES] Los modelos animales, especialmente ratón y rata, son instrumentos valiosos como indicadores predictivos de actividad clínica. Los perfiles metabólicos de biofluidos, tejidos y órganos de estos modelos pueden estar ...
Kuligowski, Julia; Pérez Guaita, David; Escobar, Javier; Guardia, Miguel de la; Vento, Máximo; Ferrer Riquelme, Alberto José; Quintás, Guillermo(Elsevier, 2013-11-15)
Variable subset selection is often mandatory in high throughput metabolomics and proteomics. However, depending on the variable to sample ratio there is a significant susceptibility of variable selection towards chance ...
Juárez Ortega, Paloma; Fernández Del Carmen, María Asunción; Rambla Nebot, Jose Luis; Presa Castro, Silvia; Mico, Amparo; Granell Richart, Antonio; Orzáez Calatayud, Diego Vicente(American Chemical Society, 2014-08-13)
The production of neutralizing immunoglobulin A (IgA) in edible fruits as a means of oral passive immunization is a promising strategy for the inexpensive treatment of mucosal diseases. This approach is based on the ...
Galvez-Fernandez, Marta; Sanchez-Saez, Francisco; Domingo-Relloso, Arce; Rodríguez-Hernández, Zulema; Tarazona, Sonia; Gonzalez-Marrachelli, Vannina; Grau-Perez, Maria; Morales-Tatay, José M.; Amigo, Nuria; Garcia-Barrera, Tamara; Gomez-Ariza, Jose L.; Chaves, F. Javier; Garcia-Garcia, Ana Barbara; Melero, Rebeca; Tellez-Plaza, Maria(Elsevier, 2022-06)
[EN] Background: Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed the association of 11 metals with metabolic patterns, and the interacting ...
Tapia González, Andrea(Universitat Politècnica de València, 2022-09-05)
[ES] El síndrome de Dravet es una epilepsia severa rara causada por mutaciones en el gen SCN1A, el cual codifica para la proteína Nav1.1, subunidad α de los canales de sodio regulados por voltaje. En esta tesis se ha ...
Tapia, Andrea; Giachello, Carlo N.; Palomino-Schätzlein, Martina; Baines, Richard A.; Galindo, Máximo Ibo(MDPI AG, 2021-11)
[EN] Dravet syndrome is a severe rare epileptic disease caused by mutations in the SCN1A gene coding for the Nav1.1 protein, a voltage-gated sodium channel alpha subunit. We have made a knock-out of the paralytic gene, the ...
Rambla Nebot, Jose Luis(Universitat Politècnica de València, 2017-01-15)
[EN] Fruits both produce and emit volatile chemical compounds. These are short-chained low polarity molecules involved in many processes, and they are responsible of our perception of fruit aroma and of most of their ...
[EN] Chronic inflammatory bowel disorders (IBD) are idiopathic diseases associated with altered intestinal permeability, which in turn causes an exaggerated immune response to enteric antigens in a genetically susceptible ...
Praena Tamayo, Jesús(Universitat Politècnica de València, 2022-09-02)
[ES] El tiempo de floración es uno de los caracteres más importantes que influyen en la productividad y el rendimiento de los cultivos. La identificación de compuestos sintéticos que sean bioactivos en el control de la ...
Chevilly-Tena, Sergio; Dolz-Edo, Laura; Morcillo, Luna; Vilagrosa, Alberto; López-Nicolás, José Manuel; Yenush, Lynne; Mulet, José Miguel(Springer (Biomed Central Ltd.), 2021-10-25)
[EN] Background Salt stress is one of the main constraints determining crop productivity, and therefore one of the main limitations for food production. The aim of this study was to characterize the salt stress response ...
Bernabeu Gómez, Elena(Universitat Politècnica de València, 2016-07-28)
[EN] In recent years the omics disciplines have made their way across a wider spectrum of
research groups, thus leading to the generation of multi-omics data sets in a great number of
studies. While traditional omics ...
Loras, Alba; Suárez-Cabrera, Cristian; Martínez-Bisbal, M.Carmen; Quintás, Guillermo; Paramio, Jesús M.; Martínez-Máñez, Ramón; Gil Grau, Salvador; Ruiz-Cerdá, José Luis(MDPI AG, 2019-05)
[EN] Metabolism reprogramming is considered a hallmark of cancer. The study of bladder cancer (BC) metabolism could be the key to developing new strategies for diagnosis and therapy. This work aimed to identify tissue and ...
Zubiri Gaitán, Agostina(Universitat Politècnica de València, 2025-01-30)
[ES] El objetivo de la Tesis fue investigar los mecanismos genéticamente determinados involucrados en la deposición de grasa intramuscular (GIM) usando 2 líneas divergentes de GIM (A y B) en el músculo Longissimus thoracis ...
[EN] In a global aging population, it is important to understand the factors affecting systemic aging and lifespan. Mitohormesis, an adaptive response caused by different insults affecting the mitochondrial network, triggers ...
Rubio Martínez-Abarca, María Teresa(Universitat Politècnica de València, 2022-09-01)
[ES] El objetivo principal de este trabajo fue conocer las alteraciones inmunológicas asociadas a la inflamación periférica que desencadenan deterioro cognitivo en los pacientes cirróticos encefalopatía hepática mínima ...
Juárez Ortega, Paloma(Universitat Politècnica de València, 2014-04-14)
Mucosal passive immunization is the transfer of active antibodies from one organism
to the mucosal surfaces of another organism for preventing or treating infectious diseases.
Mucosal passive immunization has a ...
Olea Miravet, Amal(Universitat Politècnica de València, 2023-09-14)
[ES] La polimedicación y el consumo de medicamentos está aumentando considerablemente en la población y con ello una de las reacciones adversas más habituales, el daño hepático por medicamentos (Drug Induced Liver Injury, ...
Hernández-Aparicio, Francisco Jorge; Lisón, Purificación; Rodrigo Bravo, Ismael; Belles Albert, José Mª; López-Gresa, María Pilar(MDPI AG, 2021-03-24)
[EN] New strategies of control need to be developed with the aim of economic and environmental sustainability in plant and crop protection. Metabolomics is an excellent platform for both understanding the complex plant-pathogen ...
Payá C.; Minguillón, S.; Hernández, M.; Miguel, S.M.; Campos, L.; Rodrigo Bravo, Ismael; Belles Albert, José Mª; López-Gresa, María Pilar; Lisón, Purificación(Springer (Biomed Central Ltd.), 2022-11-29)
[EN] Background Salicylic acid (SA) is a major plant hormone that mediates the defence pathway against pathogens. SA accumulates in highly variable amounts depending on the plant-pathogen system, and several enzyme activities ...
[EN] Potassium humate is a widely used biostimulant known for its ability to enhance growth and improve tolerance to abiotic stress. However, the molecular mechanisms explaining its effects remain poorly understood. In ...