Panova, Ekaterina(Universitat Politècnica de València, 2022-09-19)
[ES] Los modelos in vitro que se emplean en la detección del efecto de los fármacos en las células hepáticas
muestran limitaciones y bajo potencial de predicción. Por ello, actualmente existe una gran necesidad de
diseñar ...
[EN] We employed broadband dielectric spectroscopy (BDS), for the investigation of the water dynamics in partially hydrated hyaluronic acid (HA), and gelatin (Gel), enzymatically crosslinked hydrogels, in the water fraction ...
Vaca-González, Juan Jairo; Clara-Trujillo, Sandra; Guillot-Ferriols, María Teresa; Ródenas Rochina, Joaquín; Sanchis Sánchez, María Jesús; Gómez Ribelles, José Luís; Garzón-Alvarado, Diego Alexander; Gallego Ferrer, Gloria(Elsevier, 2020-08)
[EN] Electrical stimulation (ES) has provided enhanced chondrogenesis of mesenchymal stem cells (MSCs) cultured in micro-mass without the addition of exogenous growth factors. In this study, we demonstrate for the first ...
New in situ highly-porous chitosan/hydroxyapatite (CS/HA) biocomposite scaffolds have been prepared via freeze-gelation technique. Different content of in situ synthesized hydroxyapatite within chitosan solution was obtained ...
Kindi, Husnia; Menzel, Matthias; Heilmann, Andreas; Schmelzer, Christian E. H.; Herzberg, Martin; Fuhrmann, Bodo; Gallego-Ferrer, Gloria; Groth, Thomas(The Royal Society of Chemistry, 2021-09-28)
[EN] Polyelectrolyte multilayers (PEMs) consisting of the polysaccharides hyaluronic acid (HA) as the polyanion and chitosan (Chi) as the polycation were prepared with layer-by-layer technique (LbL). The [Chi/HA](5) ...
Guillot-Ferriols, María Teresa; del Barrio, Ana; Costa, Carlos M.; Lanceros-Méndez, Senentxu; Rodríguez-Cabello, José Carlos; Gómez Ribelles, José Luís; Santos, Mercedes; Ferrer, GG(Elsevier, 2021-03-05)
[EN] Bone's inherent piezoelectricity is a key factor in regulating bone growth and mesenchymal stem cells (MSCs) fate towards the osteogenic lineage. The piezoelectric polymer poly(vinylidene) fluoride (PVDF) was thus ...
Guillot-Ferriols, María Teresa; Lanceros-Méndez, Senentxu; Gómez Ribelles, José Luís; Gallego-Ferrer, Gloria(Elsevier, 2022-07)
[EN] Mesenchymal stem cells (MSCs) play a major role in bone tissue engineering (BTE) thanks to their capacity for osteogenic differentiation and being easily available. In vivo, MSCs are exposed to an electroactive ...
Guillot Ferriols, María Teresa(Universitat Politècnica de València, 2022-12-30)
[ES] El aumento de la esperanza de vida conlleva la aparición de problemas muscoloesqueléticos afectando a la calidad de vida de los pacientes. Las nuevas terapias regenerativas óseas se centran en el uso de las células ...
[EN] The aim of this study was to develop micro- or macro-porous substrates of poly(L-lactic acid) (PLLA) for the sustained release of water-soluble proteins. A model protein, bovine serum albumin (BSA), was incorporated ...
A hydrogel based on interpenetrating polymer networks (IPNs) has been designed to act as a platform in an articular cartilage bioreactor for the ex vivo test of scaffolds, simulating the host tissue. Poly(2-hydroxyethyl ...
A series of hydrophilic epoxy networks was prepared by reaction of a,x-diamino terminated polyoxypropylene-b-polyoxyethylene-b-polyoxypropylene of average molar mass 2000 g/mol with polyoxypropylene bis(glycidyl ether) of ...
Mares Bou, Sofía(Universitat Politècnica de València, 2021-09-24)
[ES] El daño hepático inducido por fármacos es un evento clínico que puede acarrear daños hepáticos potencialmente mortales y de alto coste y que genera la necesidad del desarrollo de plataformas de cultivo celular capaces ...
Bengoetxea González, Guillermo(Universitat Politècnica de València, 2021-01-26)
[ES] En este trabajo se recogen la información sobre sistemas de biomateriales basados en partículas (micro/nano) para la liberación de iones y sus posibles aplicaciones en el ámbito biosanitario. Las nanopartículas y ...
Rodríguez Fernández, Julio(Universitat Politècnica de València, 2019-07-03)
[ES] La terapia celular hepática (TCH) se concibe como una potencial opción terapéutica para recuperar y estabilizar la función metabólica perdida en enfermedades hepáticas de distinta etiología para mejorar los resultados ...
Talamanca Buitrago, Blanca(Universitat Politècnica de València, 2022-09-07)
[ES] El cáncer de colon es la neoplasia maligna más frecuente que se puede presentar en el tubo digestivo y, a pesar de la incesante investigación, una de las patologías con mayor prevalencia en la población mundial. El ...
Pradas Novella, Amparo(Universitat Politècnica de València, 2021-10-21)
[ES] El siguiente proyecto se divide en dos partes. Primero se realiza una búsqueda bibliográfica acerca de las propiedades del caucho, sobre todo aquel utilizado en las llantas de los neumáticos; y de los diferentes métodos ...
Deplaine, Harmony; Acosta-Santamaría, Victor A.; Vidaurre Garayo, Ana Jesús; Gómez Ribelles, José Luís; Doblare Castellano, Manuel; Ochoa-Garrido, Ignacio; Gallego Ferrer, Gloria(Wiley, 2014-10-15)
[EN] A poly(L-lactic acid) scaffold prepared by a combination of freeze-extraction and porogen-leaching methods was submitted
to static degradation in a phosphate-buffered saline solution at pH 7.4 and 37 C for up to 12 ...
[EN] Gelatin injectable hydrogels have attracted attention for soft tissues regeneration; however, their poor mechanical properties limit their applications. The authors present a versatile strategy to enhance mechanical ...
Gamboa Martínez, Tatiana Carolina; Gómez Ribelles, José Luís; Gallego Ferrer, Gloria(SAGE Publications (UK and US), 2011-09)
A hybrid scaffold was obtained by the deposition of a thin network of submicron fibrin fibrils on the microporous walls of a macroporous poly(L-lactide) (PLLA) three-dimensional structure. The fibrin coating is homogeneous ...
Gamboa Martínez, Tatiana Carolina; García Cruz, Dunia Mercedes; Carda, Carmen; Gómez Ribelles, José Luís; Gallego Ferrer, Gloria(Wiley, 2013-02)
The aim of this study was to develop a biocompatible monolayer substrate based on fibrin and chitosan for in vitro culture of chondrocytes. Fibrin-chitosan composite substrates combined the proved cell adhesion properties ...