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Listar por Patrocinador "Centro de Investigación Príncipe Felipe"

Mostrando ítems 1-17 de 17

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

Rubio, Teresa; Chernigovskaya, Maria; Marquez, Susanna; Marti, Cristina; Izquierdo-Altarejos, Paula; Urios, Amparo; Montoliu, Carmina; Felipo, Vicente; Conesa, Ana; Greiff, Victor; Tarazona, Sonia (Elsevier B.V., 2022-03-12)

[EN] T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified. However, ...
Assessment of parameters influencing fiber characteristics of electrospun Poly(ethyl methacrylate) scaffolds

Gómez-Tejedor, José Antonio; Van Overberghe, Niek; Rico Tortosa, Patricia María; Gómez Ribelles, José Luís (Elsevier, 2011)

This work evaluates the influence of electrospinning process parameters on the mean diameter and standard deviation of fiber diameters in electrospun poly(ethyl methacrylate) (PEMA). Processing conditions were selected ...
Assessment of Targeted Next-Generation Sequencing as a Tool for the Diagnosis of Charcot-Marie-Tooth Disease and Hereditary Motor Neuropathy

Lupo, Vincenzo; García-García, Francisco; Sancho, Paula; Tello, Cristina; García-Romero, Mar; Villarreal, Liliana; Alberti, Antonia; Sivera, Rafael; Pascual-Pascual, Samuel I.; Márquez-Infante, Celedonio; Casasnovas, Carlos; Sevilla, Teresa; Espinós-Armero, Carmen Ángeles (Elsevier, 2016-03)

[EN] Charcot-Marie-Tooth disease is characterized by broad genetic heterogeneity with >50 known disease-associated genes. Mutations in some of these genes can cause a pure motor form of hereditary motor neuropathy, the ...
Automatic semantic segmentation of the lumbar spine: Clinical applicability in a multi-parametric and multi-center study on magnetic resonance images

Sáenz-Gamboa, Jhon Jairo; Doménech, Julio; Alonso-Manjarrés, Antonio; Gomez, J.A.; de la Iglesia-Vayá, María (Elsevier, 2023-06)

[EN] Significant difficulties in medical image segmentation include the high variability of images caused by their origin (multi-center), the acquisition protocols (multi-parametric), the variability of human anatomy, ...
Biodegradable poly(L-lactide) and polycaprolactone block copolymer networks

Escobar Ivirico, Jorge Luis; Salmerón Sánchez, Manuel; Gómez Ribelles, José Luís; Monleón Pradas, Manuel (Wiley, 2011)

New biodegradable block copolymer networks were synthesized from methacrylate-terminated poly(L-lactide) (mLA) and polycaprolactone (mCL) macromers. This allowed the realization of a series of materials in which the macromer ...
Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles

de la torre, Cristina; Mondragón Martínez, Laura; Coll Merino, Mª Carmen; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Amoros del Toro, Pedro Jose; Pérez Payá, Enrique; Orzáez Calatayud, Mar (Wiley-VCH Verlag, 2014-11-17)

New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin ...
Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration

Gil-Castell, O.; Ontoria-Oviedo, I.; Badia, J.D.; Amaro-Prellezo, E.; Sepúlveda, P.; Ribes-Greus, Amparo (Elsevier, 2022-01)

[EN] The endorsement of functional features such as biocompatibility, mechanical integrity, or electrical conductivity to tissue engineering (TE) scaffolds is essential to stimulate cell adhesion and proliferation. In this ...
EEG-Based Functional Connectivity Analysis for Cognitive Impairment Classification

Echeverri-Ocampo, Isabel; Ardila, Karen; Molina Mateo, José; Padilla-Buritica, J. I.; Carceller, Héctor; Barcelo-Martinez, Ernesto A.; Llamur, S. I.; de la Iglesia-Vaya, María (MDPI AG, 2023-11)

[EN] Understanding how mild cognitive impairment affects global neural networks may explain changes in brain electrophysiology. Using graph theory and the visual oddball paradigm, we evaluated the functional connectivity ...
Enzyme-Responsive Intracellular-Controlled Release Using Silica Mesoporous Nanoparticles Capped with e-Poly-l-lysine

Mondragón Martínez, Laura; Mas Font, Nuria; Ferragud, Vicente; de la Torre, Cristina; Agostini, Alessandro; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Amoros del Toro, Pedro Jose; Pérez Payá, Enrique; Orzáez Calatayud, Mar (Wiley-VCH Verlag, 2014-04-25)

The synthesis and characterization of two new capped silica mesoporous nanoparticles for controlled delivery purposes are described. Capped hybrid systems consist of MCM-41 nanoparticles functionalized on the outer surface ...
Evaluation of nonpolar metabolites in plant extracts by 13C NMR spectroscopy

Palomino-Schätzlein, Martina; Escrig Aparici, Pablo Vicente; Boira Tortajada, Herminio; Primo Millo, Jaime; Pineda-Lucena, Antonio; Cabedo Escrig, Nuria (American Chemical Society, 2011-10-09)

13C nuclear magnetic resonance (NMR) spectroscopy was explored as a simple and efficient technique for the quantitative analysis of nonpolar metabolites in plants. The method was first optimized with a mixture of known ...
Hydrolytic degradation of PLLA/PCL microporous membranes prepared by freeze extraction

Gaona, Luis Andrés; Gómez Ribelles, José Luís; Perilla, Jairo Ernesto; Lebourg, Myriam Madeleine (Elsevier, 2012-09)

Poly(L-lactic acid) Poly(e-caprolactone) blends (PLLA/PCL) porous membranes were prepared by freeze extraction (a modification of freeze drying) with ratios 100/0, 80/20, 60/40, 40/60, 20/80, 0/100 in weight. Degradation ...
In Vivo Evaluation of 3-Dimensional Polycaprolactone Scaffolds for Cartilage Repair in Rabbits

Martinez-Diaz, Santos; Garcia-Giralt, Natalia; Lebourg, Myriam Madeleine; Gómez-Tejedor, José Antonio; Vila, Gemma; Caceres, Enric; Benito, Pere; Monleón Pradas, Manuel; Nogues, Xavier; Gómez Ribelles, José Luís; Monllau, Joan Carles (SAGE Publications (UK and US), 2010-03)

Background: Cartilage tissue engineering using synthetic scaffolds allows maintaining mechanical integrity and withstanding stress loads in the body, as well as providing a temporary substrate to which transplanted cells ...
Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease

Sevilla, Teresa; Lupo, Vincenzo; Martínez-Rubio, Dolores; Sancho, Paula; Sivera, Rafael; Chumillas, María J.; García-Romero, Mar; Pascual-Pascual, Samuel I.; Muelas, Nuria; Dopazo, Joaquín; Vílchez, Juan J.; Palau, Francesc; Espinós-Armero, Carmen Ángeles (Oxford University Press, 2016-01-01)

[EN] Charcot-Marie-Tooth disease (CMT) is a complex disorder with wide genetic heterogeneity. Here we present a new axonal Charcot-Marie-Tooth disease form, associated with the gene microrchidia family CW-type zinc finger ...
One-dimensional migration of olfactory ensheathing cells on synthetic materials: Experimental and numerical characterization

Perez Garnes, Manuel; Martínez Ramos, Cristina; Barcia, Juan A.; Escobar Ivirico, Jorge Luis; Gomez Pinedo, Ulises Alfonso; Vallés Lluch, Ana; Monleón Pradas, Manuel (Humana Press, 2013-07-24)

Olfactory ensheathing cells (OECs) are of great interest for regenerative purposes since they are believed to aid axonal growth. With the view set on the strategies to achieve reconnection between neuronal structures, it ...
Synthesis and properties of caprolactone and ethylene glycol copolymers for neural regeneration

Escobar Ivirico, Jorge Luis; García Cruz, Dunia Mercedes; Araque Monrós, María Carmen; Martínez Ramos, Cristina; Monleón Pradas, Manuel (Springer Verlag (Germany), 2012-07)

Copolymer networks from poly(ethylene glycol) methacrylate (PEGMA) and caprolactone 2-(methacryloyloxy) ethyl ester were synthesized and the resulting structure of the copolymer network was characterized by differential ...
Toll-like receptors in spinal cord derived neural precursor cells: implications on spinal cord injury and cell transplantation

Sánchez Petidier, Marina (Universitat Politècnica de València, 2022-02-11)

[ES] Los receptores tipo Toll, TLR, son receptores clave en la defensa contra los patógenos capaces de iniciar la respuesta inmunitaria innata para proteger al huésped. Su papel no solo se relega a responder a estímulos ...
Using GPUs for the exact alignment of short-read genetic sequences by means of the Burrows-Wheeler transform

Salavert Torres, José; Blanquer Espert, Ignacio; Tomás Domínguez, Andrés Enrique; Hernández García, Vicente; Medina Castelló, Ignacio; Tárraga Giménez, Joaquín; Dopazo Blazquez, Joaquin (Association for Computing Machinery (ACM)Institute of Electrical and Electronics Engineers (IEEE), 2012-07)

General Purpose Graphic Processing Units (GPGPUs) constitute an inexpensive resource for computing-intensive applications that could exploit an intrinsic fine-grain parallelism. This paper presents the design and ...