Garavís, M.; Bocanegra, R.; Herrero-Galán, E.; González, C.; Villasante, A.; Arias-Gonzalez, J. R.(The Royal Society of Chemistry, 2013)
[EN] We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order ...
[EN] Genomes contain rare guanine-rich sequences capable of assembling into four-stranded helical structures, termed G-quadruplexes, with potential roles in gene regulation and chromosome stability. Their mechanical unfolding ...
Bergues-Pupo, A.E.; Arias-Gonzalez, J. R.; Moron, M.C.; Fiasconaro, A.; Falo, F.(Oxford University Press, 2015-09-03)
[EN] Cations are known to mediate diverse interactions in nucleic acids duplexes but they are critical in the arrangement of four-stranded structures. Here, we use all- atom molecular dynamics simulations with explicit ...
Gutiérrez, I.; Garavís, M.; de Lorenzo, S.; Villasante, A.; González, C.; Arias-Gonzalez, J. R.(American Chemical Society, 2018-05-17)
[EN] TERRA is an RNA molecule transcribed from human subtelomeric regions toward chromosome ends potentially involved in regulation of heterochromatin stability, semiconservative replication, and telomerase inhibition, ...