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Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool

Quintás, Guillermo; Portillo Poblador, Nuria; García Cañaveras, Juan Carlos; Castell, José Vicente; Ferrer, Alberto; Lahoz, Agustín (Springer Verlag (Germany), 2012-02)

An MS-based metabolomics strategy including variable selection and PLSDA analysis has been assessed as a tool to discriminate between non-steatotic and steatotic human liver profiles. Different chemometric approaches for ...
Dansyl labeling to modulate the relative affinity of bile acids for the binding sites of human serum albumin

Rohacova, Jana; Sastre Navarro, German Ignacio; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel (American Chemical Society, 2011-09-08)

[EN] Binding of natural bile acids to human serum albumin (HSA) is an important step in enterohepatic circulation and provides a measure of liver function. In this article, we report on the use of four dansyl (Dns) derivatives ...

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