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Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers

Reig-López, Javier; M. Cuquerella-Gilabert; Bandín-Vilar, Enrique; Merino-Sanjuán, Matilde; Mangas-Sanjuán, Victor; García-Arieta, Alfredo (Elsevier, 2024-06)

[EN] The characterization of the time course of ibuprofen enantiomers can be useful in the selection of the most sensitive analyte in bioequivalence studies. Physiologically based pharmacokinetic (PBPK) modelling and ...
Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool

Figueroa-Campos, Andrés; Sánchez-Dengra, Bárbara; Merino, Virginia; Dahan, Arik; Gonzalez-Alvarez, Isabel; García-Arieta, Alfredo; Gonzalez-Alvarez, Marta; Bermejo, Marival (MDPI AG, 2020-07)

[EN] The main objective of this investigation was to develop an in vitro-in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development ...

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