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Browsing by Subject "Cell adhesion"

Now showing items 1-18 of 18

Arrangement of Type IV Collagen and Laminin on Substrates with Controlled Density of ¿OH Groups

Coelho, Nuno Miranda; González García, Cristina; Salmerón Sánchez, Manuel; Altankov, George (Mary Ann Liebert, 2011)

Collagen IV (Col IV) and laminin (Lam) are the main structural components of the basement membrane where they form two overlapping polymeric networks. We studied the adsorption pattern of these proteins on five model ...
BIOLOGICAL ACTIVITY OF FIBRONECTIN AT THE CELL-MATERIAL INTERFACE

González García, Cristina (Universitat Politècnica de València, 2012-11-05)

Esta tesis aborda la actividad biológica de la fibronectina (FN) como proteína de interfase en la interacción célula-material. La tesis investiga la respuesta de la proteína, en términos de cantidad adsorbida y conformación, ...
Biomaterials coated by dental pulp cells as substrate for neural stem cell differentiation

Soria, Jose Miguel; Sancho-Tello, María; Garcia Esparza, M. Angeles; Mirabet, Vicente; Bagan, Jose Vicente; Monleón Pradas, Manuel; Carda, Carmen (John Wiley & Sons, 2011)

[EN] This study is focused on the development of an in vitro hybrid system, consisting in a polymeric biomaterial covered by a dental pulp cellular stroma that acts as a scaffold offering a neurotrophic support for the ...
Chitosan patterning on titanium implants

Gilabert-Chirivella, Eduardo; Pérez-Feito, Ricardo; Ribeiro, Clarisse; Ribeiro, Sylvie; Correia, Daniela M.; González-Martín, Maria Luisa; Manero, Jose Maria; Lanceros-Mendez, S.; Ferrer, GG; Gómez Ribelles, José Luís (Elsevier, 2017-10)

[EN] Titanium and its alloys are widely used in medical implants because of their excellent properties. However, bacterial infection is a frequent cause of titanium-based implant failure and also compromises its osseointegration. ...
Controlled Assembly of Fibronectin Nanofibrils Triggered by Random Copolymer Chemistry

MNATSAKANYAN, HAYK; Rico Tortosa, Patricia María; Grigoriou, Eleni; Maturana Candelas, Aarón; Rodrigo Navarro, Aleixandre; Salmerón Sánchez, Manuel; Sabater i Serra, Roser (American Chemical Society, 2015-08-19)

Fibronectin fibrillogenesis is the physiological process by which cells elaborate a fibrous FN matrix. Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) ...
Differentiation of mesenchymal stem cells for cartilage tissue engineering: Individual and synergetic effects of three-dimensional environment and mechanical loading

Panadero Pérez, Juan Alberto; Lanceros-Méndez, S.; Gómez Ribelles, José Luís (Elsevier, 2016)

[EN] The importance of biomechanical cues in chondrogenesis is well known. This paper reviews the existing literature on the effect of mechanical stimulation on chondrogenic differentiation of mesenchymal stem cells in ...
Dorsal and Ventral Stimuli in Cell-Material Interactions: Effecton Cell Morphology

Ballester Beltrán, José; Lebourg, Myriam Madeleine; Rico Tortosa, Patricia María; Salmerón Sánchez, Manuel (American Vacuum Society, 2012-06)

Cells behave differently between bidimensional (2D) and tridimensional (3D) environments. While most of the in vitro cultures are 2D, most of the in vivo extracellular matrices are 3D, which encourages the development of ...
Fibrin coating on poly (L-lactide) scaffolds for tissue engineering

Gamboa Martínez, Tatiana Carolina; Gómez Ribelles, José Luís; Gallego Ferrer, Gloria (SAGE Publications (UK and US), 2011-09)

A hybrid scaffold was obtained by the deposition of a thin network of submicron fibrin fibrils on the microporous walls of a macroporous poly(L-lactide) (PLLA) three-dimensional structure. The fibrin coating is homogeneous ...
Fibrinogen organization at the cell-material interface directs endothelial cell behavior

Gugutkov, Dencho; González García, Cristina; Altankov, George; Salmerón Sánchez, Manuel (SAGE Publications, 2011)

[EN] Fibrinogen (FG) adsorption on surfaces with controlled fraction of -OH groups was investigated with AFM and correlated to the initial interaction of primary endothelial cells (HUVEC). The -OH content was tailored ...
Fibronectin distribution on demixed nanoscale topographies

Perez Garnes, Manuel; González García, Cristina; Moratal Pérez, David; Rico Tortosa, Patricia María; Salmerón Sánchez, Manuel (Wichtig Editore, 2011-02-04)

[EN] Purpose: It is known that surface nanotopography influences cell adhesion and differentiation. Our aim is to analyze the effect of nanoscale topography on fibronectin adsorption and, afterwards, on cell adhesion in ...
Functional Living Biointerphases

Saadeddin Saadeddin, Anas; Rodrigo Navarro, Aleixandre; Monedero, Vicente; Rico Tortosa, Patricia María; Moratal Pérez, David; González-Martín, María Luisa; Navarro, David; García, Andrés J.; Salmerón Sánchez, Manuel (Wiley, 2013-09)

Lactococcus lactis is modified to express a fibronectin fragment (FNIII₇₋₁₀) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal ...
Maintenance of chondrocyte phenotype during expansion on PLLA microtopographies

Costa Martínez, Elisa; González García, Cristina; Gómez Ribelles, José Luís; Salmerón Sánchez, Manuel (SAGE Publications, 2018-08-06)

[EN] Articular chondrocytes are difficult to grow, as they lose their characteristic phenotype following expansion on standard tissue culture plates. Here, we show that culturing them on surfaces of poly(L-lactic acid) of ...
Material-driven fibronectin fibrillogenesis to engineer cell function

Llopis Hernández, Virginia (Universitat Politècnica de València, 2017-11-03)

This thesis ventures with the extracellular matrix protein (ECM) fibronectin (FN) as an interface protein in the interaction between cells and materials to design microenvironment for future use in tissue engineering. It ...
Robust fabrication of electrospun-like polymer mats to direct cell behaviour

Ballester Beltrán, José; Lebourg., Myriam Madeleine; Capella Monsonís, Héctor; Díaz Lantada, Andrés; Salmerón Sánchez, Manuel (IOP Publishing: Hybrid Open Access, 2014-09)

Currently, cell culture systems that include nanoscale topography are widely used in order to provide cells additional cues closer to the in vivo environment, seeking to mimic the natural extracellular matrix. Electrospinning ...
Role of fibronectin in topographical guidance of neurite extension onelectrospun fibers

Mukhatyar, Vivek J.; Salmerón Sánchez, Manuel; Rudra, Soumon; Mukhopadaya, Shoumit; Barker, Thomas H.; Garcia, Andres J.; Bellamkonda, Ravi V. (Elsevier, 2011)

Bridging of long peripheral nerve gaps remains a significant clinical challenge. Electrospun nanofibers have been used to direct and enhance neurite extension in vitro and in vivo. While it is well established that oriented ...
Role of material-driven fibronectin fibrillogenesis in cell differentiation

Salmerón Sánchez, Manuel; Rico Tortosa, Patricia María; Moratal Pérez, David; Lee, Ted T.; Schwarzbauer, Jean E.; Garcia, Andres J. (Elsevier, 2011)

Fibronectin (FN) is a ubiquitous extracellular matrix protein (ECM) protein that is organized into fibrillar networks by cells through an integrin-mediated process that involves contractile forces. This assembly allows for ...
Role of superhydrophobicity in the biological activity of fibronectin at the cell¿material interface

Ballester Beltrán, José; Rico Tortosa, Patricia María; Moratal Pérez, David; Song, Wenlong; Mano, Joao F; Salmerón Sánchez, Manuel (Royal Society of Chemistry, 2011)

Protein adsorption and cellular behavior depend strongly on the wettability of substrates. Such studies are scarce for surfaces exhibiting extreme values of contact angles. Fibronectin (FN) adsorption and adhesion of ...
Role of surface chemistry in protein remodeling at the cell-material interface

Llopis Hernández, Virginia; Rico Tortosa, Patricia María; Ballester Beltrán, José; Moratal Pérez, David; Salmerón Sánchez, Manuel (Public Library of Science, 2011)

Background: The cell-material interaction is a complex bi-directional and dynamic process that mimics to a certain extent the natural interactions of cells with the extracellular matrix. Cells tend to adhere and rearrange ...