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Browsing by Subject "Colorectal cancer"

Now showing items 1-12 of 12

A Gene Signature Combining the Tissue Expression of Three Angiogenic Factors is a Prognostic Marker in Early-stage Non-small Cell Lung Cancer

Sanmartín, Elena; Sirera Pérez, Rafael; Usó, Marta; Blasco, Ana; Gallach, Sandra; Figueroa, Santiago; Martínez, Nieves; Hernando, Cristina; Honguero, Antonio; Martorell, Miguel; Guijarro, Ricardo; Rosell, Rafael; Jantus-Lewintre, Eloisa; Camps, Carlos (Springer Verlag (Germany), 2014-02)

[EN] Background. Angiogenesis and lymphangiogenesis are key mechanisms for tumor growth and dissemination. They are mainly regulated by the vascular endothelial growth factor (VEGF) family of ligands and receptors. The aim ...
Detección de mutaciones en el oncogén BRAF en el tratamiento dirigido frente el cáncer colorrectal

Jiménez Romero, Irene (Universitat Politècnica de València, 2017-09-08)

[ES] La presencia de mutaciones somáticas en ciertos genes se asocia a la resistencia a los tratamientos con anticuerpos monoclonales dirigidos contra el receptor de crecimiento epidérmico (EGFR), implicado en el desarrollo ...
Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer

Marcelo, Goncalo A.; Montpeyó, David; Galhano, Joana; Martínez-Máñez, Ramón; Capelo-Martínez, José Luis; Lorenzo, Julia; Lodeiro, Carlos; Oliveira, Elisabete (MDPI AG, 2023-04)

[EN] The need for non-invasive therapies capable of conserving drug efficiency and stability while having specific targetability against colorectal cancer (CRC), has made nanoparticles preferable vehicles and principal ...
Establecimiento de organoides de cáncer colorrectal como modelo preclínico

López Gil, Lucía (Universitat Politècnica de València, 2020-07-12)

[ES] Las líneas celulares y los modelos animales son los sistemas más utilizados en la investigación sobre cáncer y lo han sido durante muchos años. Sin embargo, estos sistemas modelo no son capaces de representar a la ...
Expression, localization and acetylation level of heterogeneous ribonucleoproteins (hnRNPs) depending on KRAS mutational status in colorectal cancer cell lines

González Rodríguez, Patricia (Universitat Politècnica de València, 2015-06-17)

[EN] Mutations in KRAS have been associated with resistance to anti-EGFR drugs and with a worse prognosis in colorectal cancer (CRC). KRAS membrane is a GTPase that transduce the extracellular signal from the cytoplasms ...
Fifth Educational Symposium of the Spanish Lung Cancer Group: report on the Molecular Biology Workshop

Bover, Isabel; Rolfo, Christian; Jantus Lewintre, Eloisa; Sirera Pérez, Rafael; Camps, Carlos; Chaib, Imane; Ramirez-Serrano, Jose L.; Benlloch, Susana; Molina-Vila, Miguel Angel; Simonetti, Sara; Costa, Carlota; Gimenez-Capitan, Ana; Mendez, Pedro; Taron, Miguel; Rosell, Rafael (Elsevier, 2011-12)

The majority of non-small-cell lung cancer (NSCLC) patients present with locally advanced (35%) or metastatic disease (40%); in this setting, it is of the utmost importance to balance efficacy with toxicity. However, with ...
Manejo de técnicas de biopsia líquida, generación de organoides y estudio de nuevas terapias en cáncer colorrectal

Ferreira Orero, Nerea (Universitat Politècnica de València, 2024-07-18)

[ES] El cáncer colorrectal (CCR) representa una carga significativa para la salud pública, siendo la segunda causa principal de muertes por cancer a nivel global, de acuerdo con la Organización Mundial de la Salud. Según ...
Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy

Fleitas-Kanonnikoff, Tania; Martinez-Ciarpaglini, Carolina; Ayala, Josefina; Gauna, Cinthia; Denis, Rita; Yoffe, Ita; Sforza, Silvia; Ibarrola-Villava, Maider; Pomata, Alicia; Ibarrola, Maider; Arevshatyan, Sipan; Burriel Coll, Verónica; Boscá, Diego; Pastor López, Oscar; Ferrer-Martinez, Ana (Wiley, 2019-06)

[EN] Somatic mutation analysis and evaluation of microsatellite instability (MSI) have become mandatory for selecting personalized therapy strategies for advanced colorectal cancer and are not available as routine methods ...
Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis

Gil-Raga, Mireia; Jantus-Lewintre, Eloisa; Gallach-Garcia, Sandra; Giner-Bosch, Vicent; Frangi-Caregnato, Alejandro Federico; Safont-Aguilera, María José; Garde-Noguera, Javier; Zorraquino-Pina, Estefanía; García-Martínez, Marisa; Camps-Herrero, Carlos (Springer-Verlag, 2018)

[EN] PurposeAfter surgical resection, an ample prognosis variability among stages is observed. Multiple prognostic factors are individually studied and some CRC classifiers have been proposed. Not one have been implemented ...
Prototipo de Diagnóstico de Cáncer Colorrectal Mediante un Dispositivo de Caracterización Dieléctrica de Tejidos Ex Vivo: Diseño, Metodología y Estudios Clínicos Preliminares

Micó Rosa, Sergio (Universitat Politècnica de València, 2022-10-14)

[ES] Actualmente, el cáncer de colon se ha convertido en una enfermedad que presenta una alta incidencia y mortalidad en muchos países. Debido a esto, así como a una fase asintomática prolongada, una detección temprana ...
The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer

Acevedo-León, Delia; Monzó-Beltrán, Lidia; Gómez-Abril, Segundo Ángel; Estañ-Capel, Nuria; Camarasa-Lillo, Natalia; Pérez-Ebri, Marisa Luisa; Escandón-Álvarez, Jorge; Alonso-Iglesias, Eulalia; Santaolaria-Ayora, María Luisa; Carbonell-Moncho, Araceli; Ventura-Gayete, Josep; Pla, Luis; Martínez-Bisbal, M.Carmen; Martínez-Máñez, Ramón; Bagán-Debón, Leticia; Viña-Almunia, Aurora; Martínez-Santamaría, M. Amparo; Ruiz-Luque, María; Alonso-Fernández, Jorge; Bañuls, Celia; Sáez. Guillermo (MDPI AG, 2021-06)

[EN] The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and ...
The prognostic value of hTERT expression levels in advanced-stage colorectal cancer patients: a comparison between tissue and serum expression

Safont, María José; Gil, Mireia; Sirera Pérez, Rafael; Jantus Lewintre, Eloisa; Sanmartín, Elena; Gallach, Sandra; Caballero, Cristina; Pozo, Nieves del; Palomares, Eugenio; Camps, Carlos (Springer, 2011-06)

[EN] Aim: Telomeres are regions of highly repetitive, non-coding DNA located at the termini of chromosomes whose principal function is to maintain the structural stability of these ends. In 90% of human tumours, telomere ...