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Análisis mediante simulación de la insuficiencia cardíaca en tejido ventricular humano

Gómez García, Juan Francisco (2013-02-19)

[ES] Este trabajo se centra en el desarrollo de un modelo de potencial de acción ventricular humano propio de células afectadas de insuficiencia cardíaca, para analizar la aparición de posibles efectos arritmogénicos en ...
Ca2+ alternans in human heart failure and its modulation by fibroblasts

Mora Fenoll, María Teresa; Gómez García, Juan Francisco; Ferrero De Loma-Osorio, José María; Trénor Gomis, Beatriz Ana (2019)

The functional coupling between myocytes and fibroblasts can alter the electrophysiology of myocytes, which is a major problem in heart failure. The code provides the mathematical model to simulate this interaction, and ...
Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets

Chachques, Juan C.; Monleón Pradas, Manuel; Bayes-Genis, Antoni; Semino, Carlos (Taylor & Francis, 2013)

[EN] The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from ...
Desarrollo de una herramienta web para el seguimiento y el análisis avanzado de pacientes con un dispositivo de asistencia ventricular izquierda (LVAD)

Sempere Santos, Carlos (2018-10-11)

[ES] La insuficiencia cardíaca es una enfermedad que padecen 23 millones de personas en todo el mundo. La implantación de un dispositivo de asistencia ventricular (VAD) ayuda a que los pacientes con insuficiencia cardíaca ...
El complejo del poro nuclear en la insuficiencia cardiaca

Tarazón Melguizo, Estefanía (2012-11-22)

[ES] Las manifestaciones clínicas de la insuficiencia cardiaca (IC) son resultado de cambios en los componentes celulares y moleculares del corazón para mantener un control homeostático. La IC se ha asociado con alteraciones ...
Estudio mediante simulación de las causas de la acumulación de sodio en pacientes con insuficiencia cardíaca

León Jordán, Javier (2017-01-13)

[EN] Heart failure (HF) is a disease that triggers a number of deaths from cardiac arrest, which are mainly caused by ventricular arrhythmias. In heart failure conditions, sodium accumulation occurs in the intracellular ...
Expression of B-type natriuretic peptide forms in ischemic human hearts

Cortes, Raquel; Rosello-Lleti, Esther; Rivera, Miguel; Martinez-Dolz, Luis; Salvador, Antonio; Sirera Pérez, Rafael; Portoles, Manuel (Elsevier, 2012-07-12)

Background: This study sought to determine pro-B-type natriuretic peptide (proBNP), BNP, N-terminal proBNP (NT-proBNP) and GATA-4 in the same cardiac tissue, the correlation among them, and the influence of ischemic etiology ...
Influence of heart failure on nucleolar organization and protein expression in human hearts

Rosello Lleti, Esther; Rivera, Miguel; Cortés, Raquel; Azorin, Inmaculada; Sirera Pérez, Rafael; Martínez Dolz, Luis; Hove, Leif; Cinca, Juan; Lago, Francisca; González Juanatey, José R.; Salvador, Antonio; Portolés, Manuel (Elsevier, 2012-02-10)

[EN] We investigate for the first time the influence of heart failure (HF) on nucleolar organization and proteins in patients with ischemic (ICM) or dilated cardiomyopathy (DCM). A total of 71 human hearts from ICM (n= 38) ...
Reduced response to IKr blockade and altered hERG1a/1b stoichiometryin human heart failure

Holzem, Katherine M.; Gómez García, Juan Francisco; Glukhov, Alexey V.; Madden, Eli J.; Koppel, Aaron C.; Ewald, Gregory A.; Trénor Gomis, Beatriz Ana; Efimov, Igor R. (Elsevier, 2016-07)

Heart failure (HF) claims 250,000 lives per year in the US, and nearly half of these deaths are sudden and presumably due to ventricular tachyarrhythmias. QT interval and action potential (AP) prolongation are hallmark ...
Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

Trénor Gomis, Beatriz Ana; Cardona Urrego, Karen Eliana; Gómez García, Juan Francisco; Rajamani, Sridharan; Ferrero De Loma-Osorio, José María; Belardinelli, Luiz; Saiz Rodríguez, Francisco Javier (Public Library of Science, 2012)

Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na + current (I NaL) is ...

Now showing items 1-10 of 10

Browsing by Subject "Heart failure"

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Browsing by Subject "Heart failure"