Gómez García, Juan Francisco(Universitat Politècnica de València, 2013-02-19)
[ES] Este trabajo se centra en el desarrollo de un modelo de potencial de acción ventricular humano propio
de células afectadas de insuficiencia cardíaca, para analizar la aparición de posibles efectos
arritmogénicos en ...
Mora Fenoll, María Teresa; Gómez García, Juan Francisco; Ferrero De Loma-Osorio, José María; Trénor Gomis, Beatriz Ana(2019)
The functional coupling between myocytes and fibroblasts can alter the electrophysiology of myocytes, which is a major problem in heart failure. The code provides the mathematical model to simulate this interaction, and ...
Mora-Fenoll, María Teresa; Ferrero De Loma-Osorio, José María; Gómez García, Juan Francisco; Sobie, Eric A.; Trenor Gomis, Beatriz Ana(Frontiers Media SA, 2018-08-23)
[EN] Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ ...
[EN] The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from ...
Sempere Santos, Carlos(Universitat Politècnica de València, 2018-10-11)
[ES] La insuficiencia cardíaca es una enfermedad que padecen 23 millones de personas en todo el mundo. La implantación de un dispositivo de asistencia ventricular (VAD) ayuda a que los pacientes con insuficiencia cardíaca ...
[EN] Cardiac resynchronization therapy (CRT) is an effective treatment for those patients with severe heart failure. Regrettably, there are about one third of CRT "non-responders", i.e. patients who have undergone this ...
Tarazón Melguizo, Estefanía(Universitat Politècnica de València, 2012-11-22)
[ES] Las manifestaciones clínicas de la insuficiencia cardiaca (IC) son resultado de cambios en los componentes celulares y moleculares del corazón para mantener un control homeostático. La IC se ha asociado con alteraciones ...
León Jordán, Javier(Universitat Politècnica de València, 2017-01-13)
[EN]
Heart failure (HF) is a disease that triggers a number of deaths from cardiac arrest, which are mainly caused by ventricular arrhythmias. In heart failure conditions, sodium accumulation occurs in the intracellular ...
Gutiérrez Santamaría, Sofía(Universitat Politècnica de València, 2020-07-15)
[ES] Las enfermedades cardiovasculares son la principal causa de defunción en todo el mundo según la OMS. La insuficiencia cardíaca es una de ellas y se caracteriza por la incapacidad del corazón para bombear la sangre ...
Background: This study sought to determine pro-B-type natriuretic peptide (proBNP), BNP, N-terminal proBNP (NT-proBNP) and GATA-4 in the same cardiac tissue, the correlation among them, and the influence of ischemic etiology ...
Mora Fenoll, Mª Teresa(Universitat Politècnica de València, 2020-10-26)
[EN] Heart failure, a cardiomyopathy that produces mechanical dysfunction and sudden cardiac death following fatal arrhythmias, is one of the main causes of mortality worldwide that also causes elevated morbidity rates. ...
[EN] We investigate for the first time the influence of heart failure (HF) on nucleolar organization and proteins in patients with ischemic (ICM) or dilated cardiomyopathy (DCM). A total of 71 human hearts from ICM (n= 38) ...
Carpio-Garay, Edison Fernando; Gómez García, Juan Francisco; Sebastian, Rafael; López-Pérez, Alejandro Daniel; Castellanos, Eduardo; Almendral, Jesús; Ferrero De Loma-Osorio, José María; Trenor Gomis, Beatriz Ana(Frontiers Media SA, 2019-02-11)
[EN] Patients suffering from heart failure and left bundle branch block show electrical ventricular dyssynchrony causing an abnormal blood pumping. Cardiac resynchronization therapy (CRT) is recommended for these patients. ...
Holzem, Katherine M.; Gómez García, Juan Francisco; Glukhov, Alexey V.; Madden, Eli J.; Koppel, Aaron C.; Ewald, Gregory A.; Trénor Gomis, Beatriz Ana; Efimov, Igor R.(Elsevier, 2016-07)
Heart failure (HF) claims 250,000 lives per year in the US, and nearly half of these deaths are sudden and presumably
due to ventricular tachyarrhythmias. QT interval and action potential (AP) prolongation are hallmark ...
Trénor Gomis, Beatriz Ana; Cardona Urrego, Karen Eliana; Gómez García, Juan Francisco; Rajamani, Sridharan; Ferrero De Loma-Osorio, José María; Belardinelli, Luiz; Saiz Rodríguez, Francisco Javier(Public Library of Science, 2012)
Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na + current (I NaL) is ...