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Browsing by Subject "Heart failure"

Now showing items 1-18 of 18

Análisis mediante simulación de la insuficiencia cardíaca en tejido ventricular humano

Gómez García, Juan Francisco (Universitat Politècnica de València, 2013-02-19)

[ES] Este trabajo se centra en el desarrollo de un modelo de potencial de acción ventricular humano propio de células afectadas de insuficiencia cardíaca, para analizar la aparición de posibles efectos arritmogénicos en ...
Ca2+ alternans in human heart failure and its modulation by fibroblasts

Mora Fenoll, María Teresa; Gómez García, Juan Francisco; Ferrero De Loma-Osorio, José María; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2019)

The functional coupling between myocytes and fibroblasts can alter the electrophysiology of myocytes, which is a major problem in heart failure. The code provides the mathematical model to simulate this interaction, and ...
Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

Mora-Fenoll, María Teresa; Ferrero De Loma-Osorio, José María; Gómez García, Juan Francisco; Sobie, Eric A.; Trenor Gomis, Beatriz Ana (Frontiers Media SA, 2018-08-23)

[EN] Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ ...
Consideración del Remodelado Electromecánico en Insuficiencia Cardíaca en un Modelo 3D In-Silico de Miocardiopatía Dilatada

Dasí i Martínez, Albert (Universitat Politècnica de València, 2021-02-12)

[CA] La insuficiència cardíaca (IC) és un terme ampli que inclou nombroses lesions, malalties i altres anomalies cardíaques que generen una disfunció general del miocardi. Es caracteritza per un rendiment cardíac reduït ...
Contribution to the improvement of electrical therapies and to the comprehension of electrophysiological mechanisms in heart failure and acute ischemia using computational simulation

Carpio Garay, Edison Fernando (Universitat Politècnica de València, 2021-03-02)

[ES] Una mejor comprensión de los mecanismos subyacentes a las arritmias ventriculares, así como una mejora de las terapias eléctricas y farmacológicas asociadas, son un factor clave para prevenir la muerte súbita cardíaca ...
Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets

Chachques, Juan C.; Monleón Pradas, Manuel; Bayes-Genis, Antoni; Semino, Carlos (Taylor & Francis, 2013)

[EN] The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from ...
Desarrollo de una herramienta web para el seguimiento y el análisis avanzado de pacientes con un dispositivo de asistencia ventricular izquierda (LVAD)

Sempere Santos, Carlos (Universitat Politècnica de València, 2018-10-11)

[ES] La insuficiencia cardíaca es una enfermedad que padecen 23 millones de personas en todo el mundo. La implantación de un dispositivo de asistencia ventricular (VAD) ayuda a que los pacientes con insuficiencia cardíaca ...
Early prediction of cardiac resynchronization therapy response by non-invasive electrocardiogram markers

Ortigosa, Nuria; Pérez-Roselló, Víctor; Donoso, Victor; Osca Asensi, Joaquín; Martínez-Dolz, Luis; Fernández Rosell, Carmen; Galbis Verdu, Antonio (Springer-Verlag, 2018-04)

[EN] Cardiac resynchronization therapy (CRT) is an effective treatment for those patients with severe heart failure. Regrettably, there are about one third of CRT "non-responders", i.e. patients who have undergone this ...
El complejo del poro nuclear en la insuficiencia cardiaca

Tarazón Melguizo, Estefanía (Universitat Politècnica de València, 2012-11-22)

[ES] Las manifestaciones clínicas de la insuficiencia cardiaca (IC) son resultado de cambios en los componentes celulares y moleculares del corazón para mantener un control homeostático. La IC se ha asociado con alteraciones ...
Estudio mediante simulación de las causas de la acumulación de sodio en pacientes con insuficiencia cardíaca

León Jordán, Javier (Universitat Politècnica de València, 2017-01-13)

[EN] Heart failure (HF) is a disease that triggers a number of deaths from cardiac arrest, which are mainly caused by ventricular arrhythmias. In heart failure conditions, sodium accumulation occurs in the intracellular ...
Estudio mediante simulación del acoplamiento electromecánico en células ventriculares afectadas de insuficiencia cardíaca

Gutiérrez Santamaría, Sofía (Universitat Politècnica de València, 2020-07-15)

[ES] Las enfermedades cardiovasculares son la principal causa de defunción en todo el mundo según la OMS. La insuficiencia cardíaca es una de ellas y se caracteriza por la incapacidad del corazón para bombear la sangre ...
Expression of B-type natriuretic peptide forms in ischemic human hearts

Cortes, Raquel; Rosello-Lleti, Esther; Rivera, Miguel; Martinez-Dolz, Luis; Salvador, Antonio; Sirera Pérez, Rafael; Portoles, Manuel (Elsevier, 2012-07-12)

Background: This study sought to determine pro-B-type natriuretic peptide (proBNP), BNP, N-terminal proBNP (NT-proBNP) and GATA-4 in the same cardiac tissue, the correlation among them, and the influence of ischemic etiology ...
In silico study of calcium handling in the human failing heart

Mora Fenoll, Mª Teresa (Universitat Politècnica de València, 2020-10-26)

[EN] Heart failure, a cardiomyopathy that produces mechanical dysfunction and sudden cardiac death following fatal arrhythmias, is one of the main causes of mortality worldwide that also causes elevated morbidity rates. ...
Influence of heart failure on nucleolar organization and protein expression in human hearts

Rosello Lleti, Esther; Rivera, Miguel; Cortés, Raquel; Azorin, Inmaculada; Sirera Pérez, Rafael; Martínez Dolz, Luis; Hove, Leif; Cinca, Juan; Lago, Francisca; González Juanatey, José R.; Salvador, Antonio; Portolés, Manuel (Elsevier, 2012-02-10)

[EN] We investigate for the first time the influence of heart failure (HF) on nucleolar organization and proteins in patients with ischemic (ICM) or dilated cardiomyopathy (DCM). A total of 71 human hearts from ICM (n= 38) ...
Optimization of Lead Placement in the Right Ventricle During Cardiac Resynchronization Therapy. A Simulation Study

Carpio-Garay, Edison Fernando; Gómez García, Juan Francisco; Sebastian, Rafael; López-Pérez, Alejandro Daniel; Castellanos, Eduardo; Almendral, Jesús; Ferrero De Loma-Osorio, José María; Trenor Gomis, Beatriz Ana (Frontiers Media SA, 2019-02-11)

[EN] Patients suffering from heart failure and left bundle branch block show electrical ventricular dyssynchrony causing an abnormal blood pumping. Cardiac resynchronization therapy (CRT) is recommended for these patients. ...
Reduced response to IKr blockade and altered hERG1a/1b stoichiometryin human heart failure

Holzem, Katherine M.; Gómez García, Juan Francisco; Glukhov, Alexey V.; Madden, Eli J.; Koppel, Aaron C.; Ewald, Gregory A.; Trénor Gomis, Beatriz Ana; Efimov, Igor R. (Elsevier, 2016-07)

Heart failure (HF) claims 250,000 lives per year in the US, and nearly half of these deaths are sudden and presumably due to ventricular tachyarrhythmias. QT interval and action potential (AP) prolongation are hallmark ...
Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

Trénor Gomis, Beatriz Ana; Cardona Urrego, Karen Eliana; Gómez García, Juan Francisco; Rajamani, Sridharan; Ferrero De Loma-Osorio, José María; Belardinelli, Luiz; Saiz Rodríguez, Francisco Javier (Public Library of Science, 2012)

Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na + current (I NaL) is ...
The role of beta-adrenergic system remodeling in human heart failure: A mechanistic investigation

Mora-Fenoll, María Teresa; Gong, Jingqi Q. X.; Sobie, Eric A.; Trenor Gomis, Beatriz Ana (Elsevier, 2021-04)

[EN] ß-adrenergic receptor antagonists (ß-blockers) are extensively used to improve cardiac performance in heart failure (HF), but the electrical improvements with these clinical treatments are not fully understood. The ...