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Browsing by Subject "Prodrug"

RiuNet: Institutional repository of the Polithecnic University of Valencia

Browsing by Subject "Prodrug"

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    Design of New Up-conversion Systems for Anticancer Therapies 
    Anaya González, Cristina (Universitat Politècnica de València, 2021-07-19)
    [ES] El cáncer es una de las principales causas de muerte a nivel mundial. Los tratamientos anticancerígenos generalmente usados tienen diversos efectos secundarios producidos por su baja especificidad. Esta es una de las ...
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    Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity 
    González-Gualda, Estela; Pàez-Rives, Marta; Lozano-Torres, Beatriz; Macias, David; Wilson III, Joseph R.; González-López, Cristina; Ou, Hui-Ling; MIrón-Barroso, Sofía; Zhang, Zhenguang; Lérida-Viso, Araceli; Blandez, Juan F.; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martínez-Máñez, Ramón; Muñoz-Espín, Daniel (Blackwell Publishing, 2020-04)
    [EN] Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse ...
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    Pharmacological Senolysis as a New Therapeutic Approach for the Prevention of Doxorubicin-Induced Cardiotoxicity 
    Lérida Viso, Araceli (Universitat Politècnica de València, 2023-07-06)
    [ES] La presente tesis doctoral titulada "La terapia senolítica como nuevo enfoque terapéutico para la prevención de la cardiotoxicidad inducida por la doxorrubicina" se centra en explorar la eliminación de células senescentes ...
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    Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice 
    Lerida-Viso, Araceli; Estepa-Fernández, Alejandra; Morella-Aucejo, Ángela; Lozano-Torres, Beatriz; Alfonso, María; Blandez, Juan F.; Bisbal, Viviana; Sepúlveda, Pilar; García-Fernández, Alba; Orzáez, Mar; Martínez-Máñez, Ramón (Elsevier, 2022-09)
    [EN] Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients. Cardiotoxicity is a well-known limiting factor of ...