Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner
Fecha
Autores
Díaz-Caballero, Elena
Galve, Fernando
Grau-Ruiz, Daniel
Rigla, Juan P.
González-Hernández, José Manuel
Corberán, Miguel
Directores
Unidades organizativas
Handle
https://riunet.upv.es/handle/10251/176174
Cita bibliográfica
Algarín-Guisado, JM.; Díaz-Caballero, E.; Borreguero-Morata, J.; Galve, F.; Grau-Ruiz, D.; Rigla, JP.; Bosch-Esteve, R.... (2020). Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner. Scientific Reports. 10(1):1-14. https://doi.org/10.1038/s41598-020-78456-2
Titulación
Resumen
[EN] Magnetic Resonance Imaging (MRI) of hard biological tissues is challenging due to the fleeting lifetime and low strength of their response to resonant stimuli, especially at low magnetic fields. Consequently, the impact of MRI on some medical applications, such as dentistry, continues to be limited. Here, we present three-dimensional reconstructions of ex-vivo human teeth, as well as a rabbit head and part of a cow femur, all obtained at a field strength of 260 mT. These images are the first featuring soft and hard tissues simultaneously at sub-Tesla fields, and they have been acquired in a home-made, special-purpose, pre-medical MRI scanner designed with the goal of demonstrating dental imaging at low field settings. We encode spatial information with two pulse sequences: Pointwise-Encoding Time reduction with Radial Acquisition and a new sequence we have called Double Radial Non-Stop Spin Echo, which we find to perform better than the former. For image reconstruction we employ Algebraic Reconstruction Techniques (ART) as well as standard Fourier methods. An analysis of the resulting images shows that ART reconstructions exhibit a higher signal-to-noise ratio with a more homogeneous noise distribution.
Palabras clave
ISSN
2045-2322
ISBN
Fuente
Scientific Reports
DOI
10.1038/s41598-020-78456-2
Versión del editor
https://doi.org/10.1038/s41598-020-78456-2
dc.description.uri
Código de Proyecto
info:eu-repo/grantAgreement/EC/H2020/737180/EU/IN SITU IMAGING OF LIVING TISSUES WITH CELLULAR SPATIAL RESOLUTION/
info:eu-repo/grantAgreement/AEI//RTI2018-094569-B-I00//RESONANCIA MAGNETICA DE DIFUSION PARA MEDICINA PERSONALIZADA: DEL ANALISIS A LA PREDICCION. APLICACION AL ESTUDIO DE MIGRAÑA/
info:eu-repo/grantAgreement/GVA//IDIFEDER%2F2018%2F022//EQUIPOS PARA TECNICAS MIXTAS ELECTROMAGNETICAS-ULTRASONICAS PARA IMAGEN MEDICA/
info:eu-repo/grantAgreement/AEI//RTI2018-094569-B-I00//RESONANCIA MAGNETICA DE DIFUSION PARA MEDICINA PERSONALIZADA: DEL ANALISIS A LA PREDICCION. APLICACION AL ESTUDIO DE MIGRAÑA/
info:eu-repo/grantAgreement/GVA//IDIFEDER%2F2018%2F022//EQUIPOS PARA TECNICAS MIXTAS ELECTROMAGNETICAS-ULTRASONICAS PARA IMAGEN MEDICA/
Agradecimientos
We thank anonymous donors for their tooth samples, Andrew Webb and Thomas O'Reilly (LUMC) for discussions on hardware and pulse sequences, and Antonio Tristan (UVa) for information on reconstruction techniques. This work was supported by the European Commission under Grants 737180 (FET-OPEN: HISTO-MRI) and 481 (ATTRACT: DentMRI). Action co-financed by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) of the Comunitat Valenciana 2014-2020 (IDIFEDER/2018/022). Santiago Aja-Fernandez acknowledges Ministerio de Ciencia e Innovacion of Spain for research grant RTI2018-094569-B-I00.