Enantioselective Addition of Sodium Bisulfite to Nitroalkenes. A Convenient Approach to Chiral Sulfonic Acids
Fecha
Autores
Sheikhi, Ehsan
Rezaei, Narjes
Castilla, Alvaro
Sanz-Marco, Amparo
Vila, Carlos
Pedro, Jose R.
Blay, Gonzalo
Directores
Handle
https://riunet.upv.es/handle/10251/198017
Cita bibliográfica
Sheikhi, E.; Rezaei, N.; Castilla, A.; Sanz-Marco, A.; Vila, C.; Muñoz Roca, MDC.; Pedro, JR.... (2021). Enantioselective Addition of Sodium Bisulfite to Nitroalkenes. A Convenient Approach to Chiral Sulfonic Acids. European Journal of Organic Chemistry. 2021(37):5284-5287. https://doi.org/10.1002/ejoc.202101064
Titulación
Resumen
[EN] An enantioselective organocatalytic addition of sodium bisulfite to (E)-nitroalkenes has been developed by using a chiral bifunctional organocatalyst. The present methodology provides a variety of chiral beta-nitroethanesulfonic acid compounds (17 examples) with excellent results: up to 99 % yield and excellent enantioselectivity (up to 96 % ee). The reaction tolerates (hetero)aryl and alkyl substituents on the beta-nitroalkenes, and beta,beta-disubstituted nitroalkenes.
Palabras clave
ISSN
1434-193X
ISBN
Fuente
European Journal of Organic Chemistry
DOI
10.1002/ejoc.202101064
Versión del editor
https://doi.org/10.1002/ejoc.202101064