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Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts

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Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts

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dc.contributor.author Diez-Domingo, Javier es_ES
dc.contributor.author Sánchez-Alonso, Víctor es_ES
dc.contributor.author Villanueva Micó, Rafael Jacinto es_ES
dc.contributor.author Acedo Rodríguez, Luis es_ES
dc.contributor.author Moraño Fernández, José Antonio es_ES
dc.contributor.author Villanueva-Oller, Javier es_ES
dc.date.accessioned 2018-05-26T04:22:50Z
dc.date.available 2018-05-26T04:22:50Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1999-4915 es_ES
dc.identifier.uri http://hdl.handle.net/10251/102697
dc.description.abstract [EN] The Human papillomaviruses (HPV) vaccine induces a herd immunity effect in genital warts when a large number of the population is vaccinated. This aspect should be taken into account when devising new vaccine strategies, like vaccination at older ages or male vaccination. Therefore, it is important to develop mathematical models with good predictive capacities. We devised a sexual contact network that was calibrated to simulate the Spanish epidemiology of different HPV genotypes. Through this model, we simulated the scenario that occurred in Australia in 2007, where 12¿13 year-old girls were vaccinated with a three-dose schedule of a vaccine containing genotypes 6 and 11, which protect against genital warts, and also a catch-up program in women up to 26 years of age. Vaccine coverage were 73% in girls with three doses and with coverage rates decreasing with age until 52% for 20¿26 year-olds. A fast 59% reduction in the genital warts diagnoses occurred in the model in the first years after the start of the program, similar to what was described in the literature. es_ES
dc.description.sponsorship We are grateful for the support from Sanofi Pasteur. The authors would also like to thank M. Diaz-Sanchis from the Institut Catala d'Oncologia (ICO) for her useful comments and the data provided on HPV prevalence. We would also like to thank the ICO for the HPV information centre at http://hpvcentre.net. en_EN
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Viruses es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Human papillomavirus es_ES
dc.subject Network model es_ES
dc.subject Vaccination strategies es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/v9100300 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.description.bibliographicCitation Diez-Domingo, J.; Sánchez-Alonso, V.; Villanueva Micó, RJ.; Acedo Rodríguez, L.; Moraño Fernández, JA.; Villanueva-Oller, J. (2017). Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts. Viruses. 9(10). doi:10.3390/v9100300 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.3390/v9100300 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 10 es_ES
dc.identifier.pmid 29035332 es_ES
dc.identifier.pmcid PMC5691651 es_ES
dc.relation.pasarela S\346194 es_ES
dc.contributor.funder Sanofi Pasteur


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