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Functional magnetic mesoporous silica microparticles capped with an azo-derivative: A promising colon drug delivery device

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Functional magnetic mesoporous silica microparticles capped with an azo-derivative: A promising colon drug delivery device

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dc.contributor.author Teruel, Adrián H es_ES
dc.contributor.author Coll Merino, Mª Carmen es_ES
dc.contributor.author Costero, Ana M. es_ES
dc.contributor.author Ferri, Daniel es_ES
dc.contributor.author Parra Álvarez, Margarita es_ES
dc.contributor.author Gaviña, Pablo es_ES
dc.contributor.author Gonzalez -Alvarez, Marta es_ES
dc.contributor.author Merino Sanjuán, Virginia es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.date.accessioned 2019-02-22T21:06:38Z
dc.date.available 2019-02-22T21:06:38Z
dc.date.issued 2018 es_ES
dc.identifier.issn 1420-3049 es_ES
dc.identifier.uri http://hdl.handle.net/10251/117214
dc.description.abstract [EN] Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The magnetic mesoporous microparticles were loaded with safranin O and the external surface was functionalized with an azo derivative 1 (bearing a carbamate linkage) yielding solid S1. Aqueous suspensions of S1 at pH 7.4 showed negligible safranin O release due to the presence of the bulky azo derivative attached onto the external surface of the inorganic scaffold. However, in the presence of sodium dithionite (azoreductive agent), a remarkable safranin O delivery was observed. At acidic pH, a certain safranin O release from S1 was also found. The pH-triggered safranin O delivery was ascribed to the acid-induced hydrolysis of the carbamate moiety that linked the bulky azo derivatives onto the mesoporous inorganic magnetic support. The controlled release behavior of S1 was also tested using a model that simulated the gastro intestinal tract. es_ES
dc.description.sponsorship We thank the Spanish Government (projects MAT2015-64139-C4-1-R and AGL2015-70235C2-2-R (MINECO/FEDER)) and the Generalitat Valenciana (project PROMETEOII/2014/047) for support. AHT thanks to the Spanish MEC for his FPU grant. The authors also thank the Electron Microscopy Service at the Universitat Politecnica de Valencia for support. SCSIE (Universitat de Valencia) is also gratefully acknowledged for all the equipment employed. NMR was registered at the U26 facility of ICTS "NANBIOSIS" at the Universitat de Valencia. The authors thanks L.A. Villaescusa for his helpful discussion about the 1H-NMR analysis of the composition of loaded and functionalized supports.
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//AGL2015-70235-C2-2-R/ES/DESARROLLO DE SISTEMAS HIBRIDOS CON OPTIMIZACION DEL ANCLADO DE BIOMOLECULAS Y DISEÑADOS CON PROPIEDADES DE ENCAPSULACION Y LIBERACION CONTROLADA MEJORADAS/ es_ES
dc.relation GENERALITAT VALENCIANA/PROMETEOII/2014/047 es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation.ispartof Molecules es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Magnetic mesoporous silica es_ES
dc.subject Azo derivatives es_ES
dc.subject PH triggered es_ES
dc.subject Azo reductor es_ES
dc.subject Colon release es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Functional magnetic mesoporous silica microparticles capped with an azo-derivative: A promising colon drug delivery device es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/molecules23020375 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Teruel, AH.; Coll Merino, MC.; Costero, AM.; Ferri, D.; Parra Álvarez, M.; Gaviña, P.; Gonzalez -Alvarez, M.... (2018). Functional magnetic mesoporous silica microparticles capped with an azo-derivative: A promising colon drug delivery device. Molecules. 23(2). https://doi.org/10.3390/molecules23020375 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.3390/molecules23020375 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 23 es_ES
dc.description.issue 2 es_ES
dc.identifier.pmid 29439396
dc.identifier.pmcid PMC6017295
dc.relation.pasarela S\354057 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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