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Evaluation of the porcine ACSL4 gene as a candidate gene for meat quality traits in pigs

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Evaluation of the porcine ACSL4 gene as a candidate gene for meat quality traits in pigs

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Nombre: Corominas;Ramayo- ...
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dc.contributor.author Corominas, J. es_ES
dc.contributor.author Ramayo-Caldas, Y. es_ES
dc.contributor.author Castelló, A. es_ES
dc.contributor.author Muñoz, M. es_ES
dc.contributor.author Ibáñez-Escriche, Noelia es_ES
dc.contributor.author Folch, J. M. es_ES
dc.contributor.author Ballester, M. es_ES
dc.date.accessioned 2020-03-13T08:29:17Z
dc.date.available 2020-03-13T08:29:17Z
dc.date.issued 2012-12 es_ES
dc.identifier.issn 0268-9146 es_ES
dc.identifier.uri http://hdl.handle.net/10251/138903
dc.description.abstract [EN] Long-chain acyl-CoA synthetase (ACSL) family members catalyse the formation of long-chain acyl-CoA from fatty acid, ATP and CoA, thus playing an important role in both de novo lipid synthesis and fatty acid catabolism. Previous studies in our group evaluated ACSL4 as a positional candidate gene for quantitative trait loci located on chromosome X in an Iberian x Landrace cross. A DQ144454:c.2645G>A SNP located in the 3' untranslated region of the ACSL4 gene was associated with the percentages of oleic and monounsaturated fatty acids. The aim of the present work was to evaluate the functional implication of this genetic variant. An expression analysis was performed for 120 individuals with different genotypes for the DQ144454:c.2645G>A polymorphism using real-time quantitative PCR. Differences between genotypes were identified in liver, with the ACSL4 mRNA expression levels higher in animals with the G allele than in animals with the A allele. A SNP genome-wide association study with ACSL4 relative expression levels showed significant positions on chromosomes 6 and 12. Description of positional candidate genes for ACSL4 regulation on chromosomes 6 and 12 is provided. es_ES
dc.description.sponsorship We would like to thank Dr. Jordi Estelle for help in the association studies for SSCX SNPs and Dr. Anna Mercade for the genotyping of porcine chip. This study has been funded by MICINN project (AGL2008-04818-C03). J. Corominas was funded by a FPI PhD grant from the Spanish Ministerio de Educacion (BES-2009-018223) and Y. Ramayo by a FPU PhD grant (AP2008-01450). es_ES
dc.language Inglés es_ES
dc.publisher Blackwell Publishing es_ES
dc.relation.ispartof Animal Genetics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject ACSL4 es_ES
dc.subject Fatty acid metabolism es_ES
dc.subject Genome-wide association study es_ES
dc.subject Ss-oxidation es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Evaluation of the porcine ACSL4 gene as a candidate gene for meat quality traits in pigs es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/j.1365-2052.2012.02335.x es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//AP2008-01450/ES/AP2008-01450/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AGL2008-04818-C03-02/ES/GENES CANDIDATOS E IDENTIFICACION GENOMICA DE LOCI Y RUTAS GENETICAS QUE AFECTAN A LA CALIDAD DE LA CARNE EN CERDOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AGL2008-04818-C03-03/ES/GENES CANDIDATOS E IDENTIFICACION GENOMICA DE LOCI Y RUTAS GENICAS QUE AFECTAN A LA CALIDAD DE LA CARNE EN CERDOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AGL2008-04818-C03-01/ES/GENES CANDIDATOS E IDENTIFICACION GENOMICA DE LOCI Y RUTAS GENETICAS QUE AFECTAN A LA CALIDAD DE LA CARNE EN CERDOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BES-2009-018223-2/ES/BES-2009-018223-2/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Corominas, J.; Ramayo-Caldas, Y.; Castelló, A.; Muñoz, M.; Ibáñez-Escriche, N.; Folch, JM.; Ballester, M. (2012). Evaluation of the porcine ACSL4 gene as a candidate gene for meat quality traits in pigs. Animal Genetics. 43(6):714-720. https://doi.org/10.1111/j.1365-2052.2012.02335.x es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1111/j.1365-2052.2012.02335.x es_ES
dc.description.upvformatpinicio 714 es_ES
dc.description.upvformatpfin 720 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 43 es_ES
dc.description.issue 6 es_ES
dc.relation.pasarela S\395260 es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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