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Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct

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Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct

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dc.contributor.author Ewertowska, Elzbieta es_ES
dc.contributor.author Andaluz, Anna es_ES
dc.contributor.author Moll, Xavier es_ES
dc.contributor.author Adrià Aguilar es_ES
dc.contributor.author Garcia, Felix es_ES
dc.contributor.author Fondevila, Dolors es_ES
dc.contributor.author Quesada, Rita es_ES
dc.contributor.author Trujillo Guillen, Macarena es_ES
dc.contributor.author Burdio, Fernando es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.date.accessioned 2020-03-25T07:20:49Z
dc.date.available 2020-03-25T07:20:49Z
dc.date.issued 2019-01-01 es_ES
dc.identifier.issn 0265-6736 es_ES
dc.identifier.uri http://hdl.handle.net/10251/139356
dc.description This is an Accepted Manuscript of an article published by Taylor & Francis in International Journal of Hyperthermia on Jan 01 2019, available online: http://www.tandfonline.com/10.1080/02656736.2019.1627585 es_ES
dc.description.abstract [EN] Introduction: Endoluminal sealing of the pancreatic duct by glue or sutures facilitates the management of the pancreatic stump. Our objective was to develop a catheter-based alternative for endoluminal radiofrequency (RF) sealing of the pancreatic duct. Materials and methods: We devised a novel RF ablation technique based on impedance-guided catheter pullback. First, bench tests were performed on ex vivo models to tune up the technique before the in vivo study, after which endoluminal RF sealing of a similar to 10 cm non-transected pancreatic duct was conducted on porcine models using a 3 Fr catheter. After 30 days, sealing effectiveness was assessed by a permeability test and a histological analysis. Results: The RF technique was feasible in all cases and delivered similar to 5 W of power on an initial impedance of 308 +/- 60 ohm. Electrical impedance evolution was similar in all cases and provided guidance for modulating the pullback speed to avoid tissue sticking and achieve a continuous lesion. During the follow-up the animals rate of weight gain was significantly reduced (p < 0.05). Apart from signs of exocrine atrophy, no other postoperative complications were found. At necropsy, the permeability test failed and the catheter could not be reintroduced endoluminally, confirming that sealing had been successful. The histological analysis revealed a homogeneous exocrine atrophy along the ablated segment in all the animals. Conclusions: Catheter-based RF ablation could be used effectively and safely for endoluminal sealing of the pancreatic duct. The findings suggest that a fully continuous lesion may not be required to obtain complete exocrine atrophy. es_ES
dc.description.sponsorship This work was supported by the Spanish Ministerio de Economia, Industria y Competitividad under "Plan Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad" (Grant TEC2014-52383-C3-R) and by the Spanish Ministerio de Ciencia, Innovacion y Universidades under "Programa Estatal de I+D+i Orientada a los Retos de la Sociedad" (Grant: RTI2018-094357-B-C21 and -C22). Elzbieta Ewertowska has a Predoctoral Grant (BES-2015-073285) from the Ministry of Economy, Industry and Competitiveness (Government of Spain). Also funding was received from Secretaria de Estado de Investigacion, Desarrollo e Innovacion. es_ES
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation MICINN/RTI2018-094357-B-C22 es_ES
dc.relation MINECO/TEC2014-52383-C3-1-R-AR es_ES
dc.relation MINECO/BES-2015-073285 es_ES
dc.relation AEI/RTI2018-094357-B-C21-AR es_ES
dc.relation.ispartof International Journal of Hyperthermia es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Ablation es_ES
dc.subject Endoluminal es_ES
dc.subject Pancreatic duct es_ES
dc.subject Radiofrequency es_ES
dc.subject Sealing es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1080/02656736.2019.1627585 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.description.bibliographicCitation Ewertowska, E.; Andaluz, A.; Moll, X.; Adrià Aguilar; Garcia, F.; Fondevila, D.; Quesada, R.... (2019). Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct. International Journal of Hyperthermia. 36(1):677-686. https://doi.org/10.1080/02656736.2019.1627585 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1080/02656736.2019.1627585 es_ES
dc.description.upvformatpinicio 677 es_ES
dc.description.upvformatpfin 686 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 36 es_ES
dc.description.issue 1 es_ES
dc.relation.pasarela S\391694 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES


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