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Interaction of Specialized Cardiac Conduction System With Antiarrhythmic Drugs: A Simulation Study

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Interaction of Specialized Cardiac Conduction System With Antiarrhythmic Drugs: A Simulation Study

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dc.contributor.author Dux-Santoy Hurtado, Lydia es_ES
dc.contributor.author Sebastián Aguilar, Rafael es_ES
dc.contributor.author Felix-Rodriguez, Jose es_ES
dc.contributor.author Ferrero De Loma-Osorio, José María es_ES
dc.contributor.author Saiz Rodríguez, Francisco Javier es_ES
dc.date.accessioned 2020-04-17T12:52:00Z
dc.date.available 2020-04-17T12:52:00Z
dc.date.issued 2011 es_ES
dc.identifier.issn 0018-9294 es_ES
dc.identifier.uri http://hdl.handle.net/10251/140968
dc.description.abstract [EN] The use of antiarrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are promising tools that could be used to investigate the effects of specific drugs on cardiac electrophysiology. In this paper, we study the multiscale effects of dofetilide, a drug that blocks IKr, from cellular to organ level paying special attention to its effect on heart structures, in particular the specialized cardiac conduction system (CCS). We include a model of the CCS in a patient-specific anatomical ventricular model and study the drug effects in simulations with and without a CCS. Results confirmed the expected effects of dofetilide at cellular level, increasing the action potential duration, and at organ level, prolonging the QT segment. Notable differences are shown between models with and without the CCS on action potential duration distributions. These techniques show the importance of heart heterogeneity and the global effects of the interaction of drugs with cardiac structures. © 2006 IEEE. es_ES
dc.description.sponsorship This work was supported in part by the Ministry of Science and Innovation, TEC-2008-02090 (FPI grant BES-2009-016071), in part by the Programa de Apoyo a la Investigacion y Desarrollo (PAID-06-09-2843) de la Universitat Politecnica de Valencia, and in part by the Direccion General de Politica Cientifica de la Generalitat Valenciana (GV/2010/078). Asterisk indicates corresponding author. es_ES
dc.language Inglés es_ES
dc.publisher IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC es_ES
dc.relation GV/GV/2010/078 es_ES
dc.relation MINISTERIO DE EDUCACION /TEC2008-02090 es_ES
dc.relation UPV-VIN/PAID-06-09-2843 es_ES
dc.relation MINISTERIO DE EDUCACION /BES-2009-016071 es_ES
dc.relation.ispartof IEEE Transactions on Biomedical Engineering es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Action potential duration (APD) es_ES
dc.subject Cardiac conduction system (CCS) es_ES
dc.subject Cardiac electrophysiology es_ES
dc.subject Drug modeling es_ES
dc.subject Action potential durations es_ES
dc.subject Antiarrhythmic drug es_ES
dc.subject Cardiac structure es_ES
dc.subject Cellular levels es_ES
dc.subject Computational modeling and simulation es_ES
dc.subject Conduction systems es_ES
dc.subject Dofetilide es_ES
dc.subject Drug effects es_ES
dc.subject Expected effects es_ES
dc.subject Global effects es_ES
dc.subject Multiscales es_ES
dc.subject Rhythm disorders es_ES
dc.subject Simulation studies es_ES
dc.subject Computer simulation es_ES
dc.subject Electrophysiology es_ES
dc.subject Heart es_ES
dc.subject Neurology es_ES
dc.subject Drug interactions es_ES
dc.subject Article es_ES
dc.subject Drug effect es_ES
dc.subject Heart muscle conduction system es_ES
dc.subject Heart ventricle es_ES
dc.subject QT prolongation es_ES
dc.subject Simulation es_ES
dc.subject Action Potentials es_ES
dc.subject Anti-Arrhythmia Agents es_ES
dc.subject Diffusion Tensor Imaging es_ES
dc.subject Drug Design es_ES
dc.subject Electrocardiography es_ES
dc.subject Heart Conduction System es_ES
dc.subject Heart Ventricles es_ES
dc.subject Humans es_ES
dc.subject Models, Cardiovascular es_ES
dc.subject Phenethylamines es_ES
dc.subject Sulfonamides es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Interaction of Specialized Cardiac Conduction System With Antiarrhythmic Drugs: A Simulation Study es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1109/TBME.2011.2165213 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà es_ES
dc.description.bibliographicCitation Dux-Santoy Hurtado, L.; Sebastián Aguilar, R.; Felix-Rodriguez, J.; Ferrero De Loma-Osorio, JM.; Saiz Rodríguez, FJ. (2011). Interaction of Specialized Cardiac Conduction System With Antiarrhythmic Drugs: A Simulation Study. IEEE Transactions on Biomedical Engineering. 58(12):3475-3478. https://doi.org/10.1109/TBME.2011.2165213 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1109/TBME.2011.2165213 es_ES
dc.description.upvformatpinicio 3475 es_ES
dc.description.upvformatpfin 3478 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 58 es_ES
dc.description.issue 12 es_ES
dc.relation.pasarela S\208947 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Educación es_ES
dc.contributor.funder Universitat Politècnica de València es_ES


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