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The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium

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The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium

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dc.contributor.author Reyes Olalde, J.I. es_ES
dc.contributor.author Zuñiga, V. es_ES
dc.contributor.author Serwatowska, Joanna es_ES
dc.contributor.author Chávez Montes, R.A. es_ES
dc.contributor.author Lozano-Sotomayor, P. es_ES
dc.contributor.author Herrera-Ubaldo, H. es_ES
dc.contributor.author Gonzalez Aguilera, K.L. es_ES
dc.contributor.author Ballester Fuentes, Patricia es_ES
dc.contributor.author Ripoll Samper, Juan Jose es_ES
dc.contributor.author Ezquer Garín, Juan Ignacio es_ES
dc.contributor.author Paolo, D. es_ES
dc.contributor.author Heyl, A. es_ES
dc.contributor.author Colombo, Lucia es_ES
dc.contributor.author Yanofsky, Martin es_ES
dc.contributor.author FERRANDIZ MAESTRE, CRISTINA es_ES
dc.date.accessioned 2020-09-10T03:31:27Z
dc.date.available 2020-09-10T03:31:27Z
dc.date.issued 2017-04-07 es_ES
dc.identifier.issn 1553-7390 es_ES
dc.identifier.uri http://hdl.handle.net/10251/149714
dc.description.abstract [EN] Fruits and seeds are the major food source on earth. Both derive from the gynoecium and, therefore, it is crucial to understand the mechanisms that guide the development of this organ of angiosperm species. In Arabidopsis, the gynoecium is composed of two congenitally fused carpels, where two domains: medial and lateral, can be distinguished. The medial domain includes the carpel margin meristem (CMM) that is key for the production of the internal tissues involved in fertilization, such as septum, ovules, and transmitting tract. Interestingly, the medial domain shows a high cytokinin signaling output, in contrast to the lateral domain, where it is hardly detected. While it is known that cytokinin provides meristematic properties, understanding on the mechanisms that underlie the cytokinin signaling pattern in the young gynoecium is lacking. Moreover, in other tissues, the cytokinin pathway is often connected to the auxin pathway, but we also lack knowledge about these connections in the young gynoecium. Our results reveal that cytokinin signaling, that can provide meristematic properties required for CMM activity and growth, is enabled by the transcription factor SPATULA (SPT) in the medial domain. Meanwhile, cytokinin signaling is confined to the medial domain by the cytokinin response repressor ARABIDOPSIS HISTIDINE PHOSPHOTRANSFERASE 6 (AHP6), and perhaps by ARR16 (a type-A ARR) as well, both present in the lateral domains (presumptive valves) of the developing gynoecia. Moreover, SPT and cytokinin, probably together, promote the expression of the auxin biosynthetic gene TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS 1 (TAA1) and the gene encoding the auxin efflux transporter PIN-FORMED 3 (PIN3), likely creating auxin drainage important for gynoecium growth. This study provides novel insights in the spatiotemporal determination of the cytokinin signaling pattern and its connection to the auxin pathway in the young gynoecium. es_ES
dc.description.sponsorship IRO, VMZM, HHU and PLS were supported by the Mexican National Council of Science and Technology (CONACyT) with a PhD fellowship (210085, 210100, 243380 and 219883, respectively). Work in the SDF laboratory was financed by the CONACyT grants CB-2012-177739, FC-2015-2/1061, and INFR-2015-253504, and NMM by the CONACyT grant CB-2011-165986. SDF, CF and LC acknowledge the support of the European Union FP7-PEOPLE-2009-IRSES project EVOCODE (grant no. 247587) and H2020-MSCARISE-2015 project ExpoSEED (grant no. 691109). SDF also acknowledges the Marine Biological Laboratory (MBL) in Woods Hole for a scholarship for the Gene Regulatory Networks for Development Course 2015 (GERN2015). IE acknowledges the International European Fellowship-METMADS project and the Universita degli Studi di Milano (RTD-A; 2016). Research in the laboratory of MFY was funded by NSF (grant IOS-1121055), NIH (grant 1R01GM112976-01A1) and the Paul D. Saltman Endowed Chair in Science Education (MFY). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. es_ES
dc.language Inglés es_ES
dc.publisher Public Library of Science es_ES
dc.relation.ispartof PLoS Genetics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject B response regulators es_ES
dc.subject Arabidopsis gynoecium es_ES
dc.subject Shoot-Meristemless es_ES
dc.subject Carpel development es_ES
dc.subject Functional genomics es_ES
dc.subject Hormonal-Control es_ES
dc.subject Crabs-Claw es_ES
dc.subject Growth es_ES
dc.subject Differentiation es_ES
dc.subject Polarity es_ES
dc.title The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1371/journal.pgen.1006726 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/247587/EU/Evolutionary Conservation of Regulatory Network Controlling Flower Development/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NSF//1121055/US/Transcriptional and Post-transcriptional Regulation of Fruit Development/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/691109/EU/Exploring the molecular control of seed yield in crops/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//1R01GM112976-01A1/US/A novel genetic network controlling meristem initiation and stem cell patterning/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//210085/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//210100/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//243380/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//219883/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//CB-2012-177739/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//FC-2015-2%2F1061/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//INFR-2015-253504/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//CB-2011-165986/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Reyes Olalde, J.; Zuñiga, V.; Serwatowska, J.; Chávez Montes, R.; Lozano-Sotomayor, P.; Herrera-Ubaldo, H.; Gonzalez Aguilera, K.... (2017). The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium. PLoS Genetics. 13(4):1-31. https://doi.org/10.1371/journal.pgen.1006726 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1371/journal.pgen.1006726 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 31 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 4 es_ES
dc.identifier.pmid 28388635 es_ES
dc.identifier.pmcid PMC5400277 es_ES
dc.relation.pasarela S\356255 es_ES
dc.contributor.funder National Science Foundation, EEUU es_ES
dc.contributor.funder National Institutes of Health, EEUU es_ES
dc.contributor.funder Consejo Nacional de Ciencia y Tecnología, México es_ES
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