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A Real-Time Method for Improving Stability of Monolithic Quartz Crystal Microbalance Operating under Harsh Environmental Conditions

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A Real-Time Method for Improving Stability of Monolithic Quartz Crystal Microbalance Operating under Harsh Environmental Conditions

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dc.contributor.author FERNÁNDEZ DÍAZ, ROMÁN es_ES
dc.contributor.author Calero-Alcarria, María Del Señor es_ES
dc.contributor.author Jiménez Jiménez, Yolanda es_ES
dc.contributor.author Arnau Vives, Antonio es_ES
dc.date.accessioned 2021-11-05T07:33:07Z
dc.date.available 2021-11-05T07:33:07Z
dc.date.issued 2021-06 es_ES
dc.identifier.uri http://hdl.handle.net/10251/176054
dc.description.abstract [EN] Monolithic quartz crystal microbalance (MQCM) has recently emerged as a very promising technology suitable for biosensing applications. These devices consist of an array of miniaturized QCM sensors integrated within the same quartz substrate capable of detecting multiple target analytes simultaneously. Their relevant benefits include high throughput, low cost per sensor unit, low sample/reagent consumption and fast sensing response. Despite the great potential of MQCM, unwanted environmental factors (e.g., temperature, humidity, vibrations, or pressure) and perturbations intrinsic to the sensor setup (e.g., mechanical stress exerted by the measurement cell or electronic noise of the characterization system) can affect sensor stability, masking the signal of interest and degrading the limit of detection (LoD). Here, we present a method based on the discrete wavelet transform (DWT) to improve the stability of the resonance frequency and dissipation signals in real time. The method takes advantage of the similarity among the noise patterns of the resonators integrated in an MQCM device to mitigate disturbing factors that impact on sensor response. Performance of the method is validated by studying the adsorption of proteins (neutravidin and biotinylated albumin) under external controlled factors (temperature and pressure/flow rate) that simulate unwanted disturbances. es_ES
dc.description.sponsorship This work was supported by the European Commission Horizon 2020 Programme, Capturing non-Amplified Tumor Circulating DA with Ultrasound Hydrodynamics, under Grant H2020FETOPEN-2016-2017/737212-CATCH-U-DNA. M. Calero is the recipient of the doctoral fellowship BES-2017-080246 from the Ministerio de Economia, Industria y Competitividad de Espana. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Sensors es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Monolithic quartz crystal microbalance es_ES
dc.subject Biosensor es_ES
dc.subject Discrete wavelet transform es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title A Real-Time Method for Improving Stability of Monolithic Quartz Crystal Microbalance Operating under Harsh Environmental Conditions es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/s21124166 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/737212/EU/Capturing non-Amplified Tumor Circulating DNA with Ultrasound Hydrodynamics/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//BES-2017-080246//AYUDA PARA CONTRATOS PREDOCTORALES PARA LA FORMACION DE DOCTORES/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Fernández Díaz, R.; Calero-Alcarria, MDS.; Jiménez Jiménez, Y.; Arnau Vives, A. (2021). A Real-Time Method for Improving Stability of Monolithic Quartz Crystal Microbalance Operating under Harsh Environmental Conditions. Sensors. 21(12):1-12. https://doi.org/10.3390/s21124166 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/s21124166 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 12 es_ES
dc.identifier.eissn 1424-8220 es_ES
dc.identifier.pmid 34204556 es_ES
dc.identifier.pmcid PMC8235264 es_ES
dc.relation.pasarela S\440001 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
upv.costeAPC 2165,9 es_ES


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