dc.contributor.author |
Laviós, Adrian
|
es_ES |
dc.contributor.author |
Sanz-Marco, Amparo
|
es_ES |
dc.contributor.author |
Vila, Carlos
|
es_ES |
dc.contributor.author |
Muñoz Roca, María Del Carmen
|
es_ES |
dc.contributor.author |
Pedro, José R.
|
es_ES |
dc.contributor.author |
Blay, Gonzalo
|
es_ES |
dc.date.accessioned |
2023-10-19T18:02:12Z |
|
dc.date.available |
2023-10-19T18:02:12Z |
|
dc.date.issued |
2022-03-25 |
es_ES |
dc.identifier.issn |
1523-7060 |
es_ES |
dc.identifier.uri |
http://hdl.handle.net/10251/198425 |
|
dc.description.abstract |
[EN] The diastereo- and enantioselective dearomative formal [3 + 2] cycloaddition of 2-nitrobenzofurans and alpha-aryl-alpha isocyanoacetate esters provides tricyclic compounds bearing the 3a,8b-dihydro-1H-benzofuro[2,3-c]pyrrole framework with three consecutive stereogenic centers. The reaction was enabled by a cupreine-ether organocatalyst. The reaction products were obtained with almost full diastereoselectivity and with excellent enantiomeric excesses for a number of substituted 2-nitrobenzofurans and isocyanoacetates. |
es_ES |
dc.description.sponsorship |
We acknowledge grant PID2020-116944GB-100 funded by MCIN/AEI/10.13039/501100011033 and by the "European Union Next Generation EU/PRTR", grant RyC-2016-20187 funded by MCIN/AEI/10.13039/501100011033 and by "ESF Investing in your future" to C.V., and grant FPU18/03038 funded by MEC to A.L. We acknowledge access to the NMR, MS, and X-ray facilities from the Servei Central de Suport a la Investigacio Experimental (SCSIE)-UV. Dedicated to Professor Joan Bosch, Universitat de Barcelona, on the occasion of his 75th birthday. |
es_ES |
dc.language |
Inglés |
es_ES |
dc.publisher |
American Chemical Society |
es_ES |
dc.relation.ispartof |
Organic Letters |
es_ES |
dc.rights |
Reconocimiento (by) |
es_ES |
dc.subject.classification |
FISICA APLICADA |
es_ES |
dc.title |
Metal-Free Diastereo- and Enantioselective Dearomative Formal [3+2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters |
es_ES |
dc.type |
Artículo |
es_ES |
dc.identifier.doi |
10.1021/acs.orglett.2c00427 |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116944GB-I00/ES/ESTRATEGIAS CATALITICAS ASIMETRICAS PARA LA SINTESIS DE NUEVAS ENTIDADES QUIMICAS QUIRALES CON POTENCIAL INTERES FARMACOLOGICO/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/MCIU//RYC-2016-20187//Ayudas para contratos Ramón y Cajal/ |
es_ES |
dc.relation.projectID |
info:eu-repo/grantAgreement/MCIU//FPU18%2F03038//Ayudas para la Formación del Profesorado Universitario/ |
es_ES |
dc.rights.accessRights |
Abierto |
es_ES |
dc.contributor.affiliation |
Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny |
es_ES |
dc.description.bibliographicCitation |
Laviós, A.; Sanz-Marco, A.; Vila, C.; Muñoz Roca, MDC.; Pedro, JR.; Blay, G. (2022). Metal-Free Diastereo- and Enantioselective Dearomative Formal [3+2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters. Organic Letters. 24(11):2149-2154. https://doi.org/10.1021/acs.orglett.2c00427 |
es_ES |
dc.description.accrualMethod |
S |
es_ES |
dc.relation.publisherversion |
https://doi.org/10.1021/acs.orglett.2c00427 |
es_ES |
dc.description.upvformatpinicio |
2149 |
es_ES |
dc.description.upvformatpfin |
2154 |
es_ES |
dc.type.version |
info:eu-repo/semantics/publishedVersion |
es_ES |
dc.description.volume |
24 |
es_ES |
dc.description.issue |
11 |
es_ES |
dc.identifier.pmid |
35293212 |
es_ES |
dc.identifier.pmcid |
PMC8961877 |
es_ES |
dc.relation.pasarela |
S\460600 |
es_ES |
dc.contributor.funder |
Agencia Estatal de Investigación |
es_ES |
dc.contributor.funder |
Ministerio de Ciencia, Innovación y Universidades |
es_ES |