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Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection

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Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection

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dc.contributor.author Lafforgue, Guillaume es_ES
dc.contributor.author Sardanyes Cayuela, Jose es_ES
dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.date.accessioned 2013-05-02T09:44:18Z
dc.date.available 2013-05-02T09:44:18Z
dc.date.issued 2011-03-15
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10251/28386
dc.description.abstract [EN] Understanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies. Although it has been usually assumed that virulence is a consequence of within-host replication of the parasite, viral strains may be highly virulent without experiencing large accumulation as a consequence of immunopathological host responses. Using two strains of Tobacco etch potyvirus (TEV) that show a negative relationship between virulence and accumulation rate, we first explored the evolution of virulence and fitness traits during simple and mixed infections. Short-term evolution experiments initiated with each strain independently confirmed the genetic and evolutionary stability of virulence and viral load, although infectivity significantly increased for both strains. Second, competition experiments between hypo- and hypervirulent TEV strains have shown that the outcome of competition is driven by differences in replication rate. A simple mathematical model has been developed to analyze the dynamics of these two strains during coinfection. The model qualitatively reproduced the experimental results using biologically meaningful parameters. Further analyses of the model also revealed a wide parametric region in which a low-fitness but hypovirulent virus can still outcompete a high-fitness but hypervirulent one. These results provide additional support es_ES
dc.description.sponsorship This work was funded by grants from the Human Frontier Science Program Organization (RGP12/2008), the Spanish Ministerio de Ciencia e Innovacion (BFU2009-06993) and the Generalitat Valenciana (PROMETEO2010/019). The authors also acknowledge support from the Santa Fe Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language Inglés es_ES
dc.publisher Public Library of Science es_ES
dc.relation.ispartof PLoS ONE es_ES
dc.rights Reconocimiento (by) es_ES
dc.title Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1371/journal.pone.0017917
dc.relation.projectID info:eu-repo/grantAgreement/HFSP//RGP0012%2F2008/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BFU2009-06993/ES/Biologia Evolutiva Y De Sistemas De La Emergencia De Fitovirus De Rna/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F019/ES/Implicaciones evolutivas de la supresión del silenciamiento del RNA por parte de proteína virales/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Lafforgue, G.; Sardanyes Cayuela, J.; Elena Fito, SF. (2011). Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection. PLoS ONE. 6:17917-17917. https://doi.org/10.1371/journal.pone.0017917 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1371/journal.pone.0017917 es_ES
dc.description.upvformatpinicio 17917 es_ES
dc.description.upvformatpfin 17917 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 6 es_ES
dc.relation.senia 218186
dc.identifier.pmid 21423618 en_EN
dc.identifier.pmcid PMC3057992 en_EN
dc.contributor.funder Human Frontier Science Program Organization
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Generalitat Valenciana
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