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Computational methodology to determine fluid related parameters on non regular three-dimensional scaffolds.

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Computational methodology to determine fluid related parameters on non regular three-dimensional scaffolds.

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dc.contributor.author Acosta Santamaría, Víctor Andrés es_ES
dc.contributor.author Malvé, M. es_ES
dc.contributor.author Duizabo, A. es_ES
dc.contributor.author Mena Tobar, A. es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.contributor.author García Aznar, J.M. es_ES
dc.contributor.author Doblare Castellano, Manuel es_ES
dc.contributor.author Ochoa, I. es_ES
dc.date.accessioned 2015-06-02T11:32:28Z
dc.date.available 2015-06-02T11:32:28Z
dc.date.issued 2013-11
dc.identifier.issn 0090-6964
dc.identifier.uri http://hdl.handle.net/10251/51142
dc.description.abstract The application of three-dimensional (3D) biomaterials to facilitate the adhesion, proliferation, and differentiation of cells has been widely studied for tissue engineering purposes. The fabrication methods used to improve the mechanical response of the scaffold produce complex and non regular structures. Apart from the mechanical aspect, the fluid behavior in the inner part of the scaffold should also be considered. Parameters such as permeability (k) or wall shear stress (WSS) are important aspects in the provision of nutrients, the removal of metabolic waste products or the mechanically-induced differentiation of cells attached in the trabecular network of the scaffolds. Experimental measurements of these parameters are not available in all labs. However, fluid parameters should be known prior to other types of experiments. The present work compares an experimental study with a computational fluid dynamics (CFD) methodology to determine the related fluid parameters (k and WSS) of complex non regular poly(L-lactic acid) scaffolds based only on the treatment of microphotographic images obtained with a microCT (lCT). The CFD analysis shows similar tendencies and results with low relative difference compared to those of the experimental study, for high flow rates. For low flow rates the accuracy of this prediction reduces. The correlation between the computational and experimental results validates the robustness of the proposed methodology. es_ES
dc.description.sponsorship The authors gratefully acknowledge research support from the Spanish Ministry of Science and Innovation through research project DPI2010-20399-C04-01. The Instituto de Salud Carlos III (ISCIII) through the CIBER initiative and the Platform for Biological Tissue Characterization of the Centro de Investigacion Biomedica en Red en Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN) are also gratefully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation Spanish Ministry of Science and Innovation project DPI2010-20399-C04- 01 es_ES
dc.relation.ispartof Annals of Biomedical Engineering es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Darcy’s law es_ES
dc.subject Tissue engineering es_ES
dc.subject Scaffolds es_ES
dc.subject Permeability es_ES
dc.subject Computational fluid dynamics es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Computational methodology to determine fluid related parameters on non regular three-dimensional scaffolds. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10439-013-0849-8
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Acosta Santamaría, VA.; Malvé, M.; Duizabo, A.; Mena Tobar, A.; Gallego Ferrer, G.; García Aznar, J.; Doblaré Castellano, M.... (2013). Computational methodology to determine fluid related parameters on non regular three-dimensional scaffolds. Annals of Biomedical Engineering. 41(11):2367-2380. doi:10.1007/s10439-013-0849-8 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/dx.doi.org/10.1007/s10439-013-0849-8 es_ES
dc.description.upvformatpinicio 2367 es_ES
dc.description.upvformatpfin 2380 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 41 es_ES
dc.description.issue 11 es_ES
dc.relation.senia 262114
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