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Seeking to shed some light on the binding of fluoroquinolones to albumins

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Seeking to shed some light on the binding of fluoroquinolones to albumins

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dc.contributor.author Bosca Mayans, Francisco es_ES
dc.date.accessioned 2016-01-13T07:49:07Z
dc.date.issued 2012-03-22
dc.identifier.issn 1520-6106
dc.identifier.uri http://hdl.handle.net/10251/59770
dc.description.abstract Interactions between serum albumins (HSA, human, and BSA, bovine) and fluoroquinolones (FQs), such as enoxacin, norfloxacin, ciprofloxacin, and ofloxacin, have been studied using the laser flash photolysis technique. Lifetimes and quantum yields of FQs triplet excited states ((3)FQs) are not affected by the presence of albumins, however, the quenching of (3)FQs by tryptophan and tyrosine and the subsequent generation of FQs. radical anions and tyrosyl or tryptophanyl radicals were detected. These results, besides agreeing with association constants (K-a) for FQs binding to albumins lower than 6 x 10(2) M-1, are highly relevant to understanding the process of photohapten formation, the first event in the onset of photoallergy. The emission of tryptophan within albumin is not affected by the presence of FQs when the inner filter effects (IFE) of these drugs are taken into account, which explains the discrepancies reported in the literature about K-a of FQs with albumins. es_ES
dc.description.sponsorship Financial support from Spanish government (CTQ2010-19909) is gratefully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof Journal of Physical Chemistry B es_ES
dc.rights Reserva de todos los derechos es_ES
dc.title Seeking to shed some light on the binding of fluoroquinolones to albumins es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1021/jp208930q
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2010-19909/ES/MECANISMOS IMPLICADOS EN LA FOTO-REACTIVIDAD ENTRE FARMACOS CON PROPIEDADES ANTINEOPLASICAS Y SUS BIOMOLECULAS DIANA/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Bosca Mayans, F. (2012). Seeking to shed some light on the binding of fluoroquinolones to albumins. Journal of Physical Chemistry B. 116(11):3504-3511. https://doi.org/10.1021/jp208930q es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1021/jp208930q es_ES
dc.description.upvformatpinicio 3504 es_ES
dc.description.upvformatpfin 3511 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 116 es_ES
dc.description.issue 11 es_ES
dc.relation.senia 242368 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES


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