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A chemosensor bearing sulfonyl azide moieties for selective chromo-fluorogenic hydrogen sulfide recognition in aqueous media and in living cells

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A chemosensor bearing sulfonyl azide moieties for selective chromo-fluorogenic hydrogen sulfide recognition in aqueous media and in living cells

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dc.contributor.author Santos Figueroa, Luis Enrique es_ES
dc.contributor.author De la Torre Paredes, Cristina es_ES
dc.contributor.author El Sayed Shehata Nasr, Sameh es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Costero Nieto, Ana María es_ES
dc.contributor.author Gil Grau, Salvador es_ES
dc.contributor.author Parra, Margarita es_ES
dc.date.accessioned 2016-03-01T15:34:01Z
dc.date.issued 2014-03
dc.identifier.issn 1434-193X
dc.identifier.uri http://hdl.handle.net/10251/61332
dc.description.abstract A simple chemodosimeter based on a sulfonyl azide dye (1-Az), which displayed a highly selective response toward hydrogen sulfide anion in mixed aqueous media, was synthesised and characterised. Addition of hydrogen sulfide to acetonitrile/HEPES 1:1 solutions of 1-Az induced a clear colour change from red-orange to yellow, which was easily detected by the naked eye, and by an enhancement in the emission intensity. Other common anions, thiol-containing biomolecules and oxidants did not induce any noticeable colour or fluorescence modulation in the probe. The chemodosimeter also showed a good sensitivity, with limits of detection of 11.91 and 0.63 μm by using UV/Vis or fluorescence measurements, respectively. Moreover, 1-Az could be used for real-time fluorescence imaging of intracellular HS at micromolar concentrations. es_ES
dc.description.sponsorship The authors thank the Spanish Government (project MAT2012-38429-C04-01), the Generalitat Valenciana (project PROMETEO/2009/016) and CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN) for their support. The authors are also grateful to Fundacion Carolina and UPNFM Honduras (doctoral grant to L. E. S.-F.) and the Generalitat Valenciana for Santiago Grisolia (fellowship to S. E. S.). en_EN
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation Spanish Government MAT2012-38429-C04-01 es_ES
dc.relation Generalitat Valenciana PROMETEO/2009/016 es_ES
dc.relation CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN) es_ES
dc.relation.ispartof European Journal of Organic Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Analytical methods es_ES
dc.subject Sensors es_ES
dc.subject Hydrogen sulfide es_ES
dc.subject Sulfur es_ES
dc.subject Azides es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title A chemosensor bearing sulfonyl azide moieties for selective chromo-fluorogenic hydrogen sulfide recognition in aqueous media and in living cells es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/ejoc.201301514
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Santos Figueroa, LE.; De La Torre Paredes, C.; El Sayed Shehata Nasr, S.; Sancenón Galarza, F.; Martínez-Máñez, R.; Costero Nieto, AM.; Gil Grau, S.... (2014). A chemosensor bearing sulfonyl azide moieties for selective chromo-fluorogenic hydrogen sulfide recognition in aqueous media and in living cells. European Journal of Organic Chemistry. 2014(9):1848-1854. doi:10.1002/ejoc.201301514 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/ejoc.201301514 es_ES
dc.description.upvformatpinicio 1848 es_ES
dc.description.upvformatpfin 1854 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 2014 es_ES
dc.description.issue 9 es_ES
dc.relation.senia 268736 es_ES
dc.identifier.eissn 1099-0690


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