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MicroRNA precursors are not structurally robust but plastic

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MicroRNA precursors are not structurally robust but plastic

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dc.contributor.author Rodrigo Tarrega, Guillermo es_ES
dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.date.accessioned 2016-07-22T09:13:18Z
dc.date.available 2016-07-22T09:13:18Z
dc.date.issued 2013
dc.identifier.issn 1759-6653
dc.identifier.uri http://hdl.handle.net/10251/68012
dc.description.abstract Robustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate null model. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs. es_ES
dc.description.sponsorship The authors thank R. B. R. Azevedo for useful comments. This work was supported by an EMBO long-term fellowship co-funded by Marie Curie actions (ALTF-1177-2011) to G. R. and by grant BFU2012-30805 from the Spanish Secretaria de Estado de Investigacion, Desarrollo e Innovacion, to S.F.E. en_EN
dc.language Español es_ES
dc.publisher Oxford University Press (OUP) es_ES
dc.relation.ispartof Genome Biology and Evolution es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Conformational flexibility es_ES
dc.subject Evolvability es_ES
dc.subject Noncoding RNA es_ES
dc.subject Secondary structure es_ES
dc.subject Thermodynamics es_ES
dc.title MicroRNA precursors are not structurally robust but plastic es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1093/gbe/evs132
dc.relation.projectID info:eu-repo/grantAgreement/EC/Marie Skłodowska-Curie Actions/ALTF-1177-2011/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2012-30805/ES/EVOLUTIONARY SYSTEMS VIROLOGY: EPISTASIS AND THE RUGGEDNESS OF ADAPTIVE LANDSCAPES, MUTATIONS IN REGULATORY SEQUENCES, AND THE HOST DETERMINANTS OF VIRAL FITNESS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Rodrigo Tarrega, G.; Elena Fito, SF. (2013). MicroRNA precursors are not structurally robust but plastic. Genome Biology and Evolution. 5(1):181-186. https://doi.org/10.1093/gbe/evs132 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1093/gbe/evs132 es_ES
dc.description.upvformatpinicio 181 es_ES
dc.description.upvformatpfin 186 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.description.issue 1 es_ES
dc.relation.senia 233407 es_ES
dc.identifier.pmid 23275486 en_EN
dc.identifier.pmcid PMC3595027 en_EN
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder European Molecular Biology Organization es_ES
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