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Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue

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Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue

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dc.contributor.author Javanmard, A. S. es_ES
dc.contributor.author Bahrami, A. R. es_ES
dc.contributor.author Mahmoudi, Z. es_ES
dc.contributor.author Saeinasab, M. es_ES
dc.contributor.author Mahdavi-Shahri, N. es_ES
dc.contributor.author Matin, M.M. es_ES
dc.date.accessioned 2016-09-07T10:03:05Z
dc.date.available 2016-09-07T10:03:05Z
dc.date.issued 2016-06-29
dc.identifier.issn 1257-5011 es_ES
dc.identifier.uri http://hdl.handle.net/10251/68973
dc.description.abstract [EN] Epimorphic regeneration in New Zealand rabbit ear is an interesting example of mammalian wound healing in which blastema formation is involved in replacement of injured tissues. It has been suggested that isolated cells from regenerating rabbit ear possess stem-like properties. In this study, we aimed to determine the expression of stemness markers, OCT4 and SOX2 proteins, in regenerating rabbit tissues by immunohistochemistry. Results indicated that both proteins could be detected in epithelial cells, hair follicle cells and perichondrium cells. Expression pattern analysis of OCT4 and SOX2 proteins showed no clear differences between regenerative and non-regenerative control tissues. According to several reports of OCT4 and SOX2 proteins expression in adult stem cells, it could be proposed that OCT4 and SOX2 expressing cells in regenerating rabbit ear tissues are progenitor/adult stem cells which are resident in these tissues, and other markers should be used for detection of blastema cells. es_ES
dc.description.sponsorship This work was supported by a grant (No. 6660) from Ferdowsi University of Mashhad, Iran. We appreciate Dr. Fatemeh B. Rassouli and Miss Malihe Akbarzadeh Niaki for their great technical support.
dc.language Inglés es_ES
dc.publisher Editorial Universitat Politècnica de València
dc.relation.ispartof World Rabbit Science es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Regenerating rabbit ear es_ES
dc.subject OCT4 es_ES
dc.subject SOX2 es_ES
dc.subject Adult stem cells es_ES
dc.title Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue es_ES
dc.type Artículo es_ES
dc.date.updated 2016-09-07T07:13:09Z
dc.identifier.doi 10.4995/wrs.2016.3965 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FUM//6660/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Javanmard, AS.; Bahrami, AR.; Mahmoudi, Z.; Saeinasab, M.; Mahdavi-Shahri, N.; Matin, M. (2016). Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue. World Rabbit Science. 24(2):155-164. https://doi.org/10.4995/wrs.2016.3965 es_ES
dc.description.accrualMethod SWORD es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2016.3965 es_ES
dc.description.upvformatpinicio 155 es_ES
dc.description.upvformatpfin 164 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24
dc.description.issue 2
dc.identifier.eissn 1989-8886 es_ES
dc.contributor.funder Ferdowsi University of Mashhad es_ES


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