Díez, P.; Sanchez, A.; Gamella, M.; Paloma Martinez-Ruiz; Aznar, E.; De La Torre, C.; Murguía, JR.... (2014). Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles. Journal of the American Chemical Society. 136(25):9116-9123. https://doi.org/10.1021/ja503578b
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/74804
Title:
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Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles
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Author:
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Díez, Paula
Sanchez, Alfredo
Gamella, María
Paloma Martinez-Ruiz
Aznar, Elena
De La Torre, Cristina
Murguía, Jose R.
Martínez-Máñez, Ramón
Villalonga, Reynaldo
Pingarrón, J.M.
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UPV Unit:
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Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
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Issued date:
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Abstract:
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We report herein the design of a smart delivery system in
which cargo delivery from capped mesoporous silica (MS) nanoparticles is
controlled by an integrated enzyme-based control unit . The system consists
of Janus-type ...[+]
We report herein the design of a smart delivery system in
which cargo delivery from capped mesoporous silica (MS) nanoparticles is
controlled by an integrated enzyme-based control unit . The system consists
of Janus-type nanoparticles having opposing Au and MS faces, functionalized
with a pH-responsive β-cyclodextrin-based supramolecular nanovalve on the
MS surface and two effectors, glucose oxidase and esterase, immobilized on
the Au face. The nanodevice behaves as an enzymatic logical OR operator
which is selectively fueled by the presence of D-glucose and ethyl butyrate.
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Subjects:
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MESOPOROUS SILICA NANOPARTICLES
,
RESPONSIVE CONTROLLED-RELEASE
,
DRUG-DELIVERY
,
GUEST MOLECULES
,
BENZIMIDAZOLE
,
THERAPY
,
DRIVEN
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Copyrigths:
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Cerrado |
Source:
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Journal of the American Chemical Society. (issn:
0002-7863
)
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DOI:
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10.1021/ja503578b
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Publisher:
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American Chemical Society
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Publisher version:
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https://dx.doi.org/10.1021/ja503578b
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Project ID:
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info:eu-repo/grantAgreement/MICINN//CTQ2011-24355/ES/NUEVOS NANOMATERIALES POLIFUNCIONALIZADOS PARA LA CONSTRUCCION DE BIOSENSORES DE DETECCION MULTIPLE/
...[+]
info:eu-repo/grantAgreement/MICINN//CTQ2011-24355/ES/NUEVOS NANOMATERIALES POLIFUNCIONALIZADOS PARA LA CONSTRUCCION DE BIOSENSORES DE DETECCION MULTIPLE/
info:eu-repo/grantAgreement/Gobierno de la Comunidad de Madrid//S2009%2FPPQ-1642/ES/Nuevas Tecnologías para el desarrollo de plataformas sensoras y biosensoras avanzadas/
info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO09%2F2009%2F016/ES/Ayuda prometeo 2009 para el grupo de diseño y desarrollo de sensores/
info:eu-repo/grantAgreement/MICINN//CTQ2009-12650/ES/NUEVAS ESTRATEGIAS DE PREPARACION DE INMUNOSENSORES ELECTROQUIMICOS BASADOS EN NANOMATERIALES CON APLICACION A LA DETECCION DE SUSTANCIAS DOPANTES Y HORMONAS DE BAJO PESO MOLECULAR/
info:eu-repo/grantAgreement/MICINN//CTQ2009-09351/ES/BIOPLATAFORMAS ELECTROANALITICAS PARA MULTIDETECCION: DE ELECTRODOS DUALES SERIGRAFIADOS A NANOARRAYS DE BIOELECTRODOS/
info:eu-repo/grantAgreement/MINECO//MAT2012-38429-C04-01/ES/DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO /
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Thanks:
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R.V. acknowledges a Ramon & Cajal contract from the Spanish Ministry of Science and Innovation. Financial support from the Spanish Ministry of Science and Innovation (CTQ2011-24355, CTQ2009-12650, CTQ2009-09351, ...[+]
R.V. acknowledges a Ramon & Cajal contract from the Spanish Ministry of Science and Innovation. Financial support from the Spanish Ministry of Science and Innovation (CTQ2011-24355, CTQ2009-12650, CTQ2009-09351, MAT2012-38429-C04-01) and Comunidad de Madrid (S2009/PPQ-1642, programme AVANSENS) is gratefully acknowledged. The Generalitat Valencia (project PROMETEO/2009/016) is also acknowledged.
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Type:
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Artículo
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