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Curcumin-Based "Enhanced SNAr" Promoted Ultrafast Fluorescent Probe for Thiophenols Detection in Aqueous Solution and in Living Cells

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Curcumin-Based "Enhanced SNAr" Promoted Ultrafast Fluorescent Probe for Thiophenols Detection in Aqueous Solution and in Living Cells

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dc.contributor.author Yue, Y es_ES
dc.contributor.author Huo, F es_ES
dc.contributor.author Zhang, Y. es_ES
dc.contributor.author Chao, Jianbin es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Yin, C. es_ES
dc.date.accessioned 2017-03-27T08:28:16Z
dc.date.issued 2016-11-01
dc.identifier.issn 0003-2700
dc.identifier.uri http://hdl.handle.net/10251/79086
dc.description.abstract We report herein a highly selective and sensitive turn-on fluorescent probe (compound 1) with a fast response time (less than 2 min) for thiophenol detection based on an enhanced SNAr reaction between thiophenols and a sulfonyl-ester moiety covalently attach to curcumin. Reaction of 1 in Hepes-MeOH (1:1, v/v, pH 7.4) in the presence of 4-methylthiophenol (MTP) resulted in a remarkable enhancement of the fluorescence. A linear response in the presence of MTP of the relative fluorescent intensity (F - F0) of 1 at 536 nm in the 0-40 mu M MTP concentration range was found. A limit of detection (LOD) for the detection of MTP of 26 nM, based on the definition by IUPAC (C-DL = 3 Sb/m), was calculated. Probe 1 was applied to monitor and imaging exogenous MTP in live cells and to the detection of MTP in real water samples. es_ES
dc.description.sponsorship The work was supported by the National Natural Science Foundation of China (Grant No. 21472118, 21672131), the Program for the Top Young and Middle-Aged Innovative Talents of Higher Learning Institutions of Shanxi (TYMIT, Grant No. 2013802), Talents Support Program of Shanxi Province (Grant No. 2014401), Shanxi Province Outstanding Youth Fund (Grant No. 2014021002), Scientific Instrument Center, Shanxi University and Shanxi University funds for study aboard 2014. The Generalitat Valenciana (Project PROMETEOII/2014/047) and the Spanish Government (Projects MAT2012-38429-C04 and MAT2015-64139-C4-1 MINECO/FEDER)) are also gratefully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof Analytical Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject CHROMENE CLICK CHEMISTRY es_ES
dc.subject SELECTIVE DETECTION es_ES
dc.subject WATER SAMPLES es_ES
dc.subject THIOL PROBE es_ES
dc.subject IN-VITRO es_ES
dc.subject GLUTATHIONE es_ES
dc.subject TOXICITY es_ES
dc.subject CYSTEINE es_ES
dc.subject TISSUES es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Curcumin-Based "Enhanced SNAr" Promoted Ultrafast Fluorescent Probe for Thiophenols Detection in Aqueous Solution and in Living Cells es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1021/acs.analchem.6b02520
dc.relation.projectID info:eu-repo/grantAgreement/NSFC//21672131/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Talents Support Program of Shanxi Province//2013802/CN es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2012-38429-C04-01/ES/DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NSFC//21472118/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Talents Support Program of Shanxi Province//2014401/CN es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Shanxi Province Outstanding Youth Fund//2014021002/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Yue, Y.; Huo, F.; Zhang, Y.; Chao, J.; Martínez-Máñez, R.; Yin, C. (2016). Curcumin-Based "Enhanced SNAr" Promoted Ultrafast Fluorescent Probe for Thiophenols Detection in Aqueous Solution and in Living Cells. Analytical Chemistry. 88(21):10499-10503. https://doi.org/10.1021/acs.analchem.6b02520 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi. org/10.1021/acs.analchem.6b02520 es_ES
dc.description.upvformatpinicio 10499 es_ES
dc.description.upvformatpfin 10503 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 88 es_ES
dc.description.issue 21 es_ES
dc.relation.senia 323335 es_ES
dc.identifier.eissn 1520-6882
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Talents Support Program of Shanxi Province es_ES
dc.contributor.funder National Natural Science Foundation of China es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Scientific Instrument Center, SXU es_ES
dc.contributor.funder Shanxi University es_ES
dc.contributor.funder Shanxi Province Outstanding Youth Fund


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